Nonapeptide influences on social behaviour: effects of vasotocin and isotocin on shoaling and interaction in zebrafish

Lindeyer, Charlotte M.; Langen, Esther M. A.; Swaney, William T.; Reader, Simon M.

doi:10.1163/1568539x-00003261

Cited by 28 publications

(20 citation statements)

References 55 publications

(68 reference statements)

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“…Interestingly, the same highest OXT concentration that did not induce changes in sociality as reported in a study by Braida et al was also found to recover the deficits of social preference mediated by MK‐801 in an independent study without affecting the preference for the conspecifics when administered alone . Furthermore, although OXT‐like peptides do not increase zebrafish preference for the shoal, vasopressin‐like peptides do or exhibit the same dose‐dependent effect observed for OXT‐like peptides …”

Section: Introductionsupporting

confidence: 68%

“…The majority of these studies employed pharmacological approaches using varied concentrations of exogenous OXT‐like peptides and/or receptor agonists and antagonists. Although, in some studies, the administration of OXT‐like peptides or its receptor agonist has shown to decrease or not to change social preference in cooperatively breeding cichlids, Neolamprologus pulcher and in zebrafish, other studies, using lower concentrations of these ligands, showed an effect in social preference that followed an inverted‐U dose‐response curve . Interestingly, the same highest OXT concentration that did not induce changes in sociality as reported in a study by Braida et al was also found to recover the deficits of social preference mediated by MK‐801 in an independent study without affecting the preference for the conspecifics when administered alone .…”

Section: Introductionmentioning

confidence: 77%

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Oxytocin receptor signalling modulates novelty recognition but not social preference in zebrafish

Ribeiro

Nunes

Gliksberg

et al. 2020

J Neuroendocrinology

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| INTRODUC TI ONNonapeptides are known to be important players in the regulation of social behaviour across taxa. 1 They evolved from a common ancestral molecule, the arginine vasotocin, after a gene duplication event in early-jawed fish. 2 One copy originated the vasopressin-like peptides, which retained the most primitive functions of the ancestral molecule, namely the regulation of osmotic balance. The other originated the oxytocin (OXT)-like peptides, which have greatly diverged across species, being recruited for diverse homeostatic processes, including parturition and lactation in mammals. Throughout evolution, these nonapeptides have also been involved in the regulation of social behaviours, with vasopressin being more involved in aggression and agonistic behaviours and OXT in affiliative behaviours and sociality. 3 AbstractSociality is a complex phenomenon that involves the individual´s motivation to approach their conspecifics, along with social cognitive functions that enable individuals to interact and survive. The nonapeptide oxytocin (OXT) is known to regulate sociality in many species. However, the role of OXT in specific aspects of sociality is still not well understood. In the present study, we investigated the contribution of the OXT receptor (OXTR) signalling in two different aspects of zebrafish social behaviour: social preference, by measuring their motivation to approach a shoal of conspecifics, and social recognition, by measuring their ability to discriminate between a novel and familiar fish, using a mutant zebrafish lacking a functional OXTR. Although oxtr mutant zebrafish displayed normal attraction to a shoal of conspecifics, they exhibited reduced social recognition. We further investigated whether this effect would be social-domain specific by replacing conspecific fish by objects. Although no differences were observed in object approach, oxtr mutant fish also exhibited impaired object recognition. Our findings suggest that OXTR signalling regulates a more general memory recognition of familiar vs novel entities, not only in social but also in a non-social domain, in zebrafish. K E Y W O R D Sautism spectrum disorders, oxytocin, social preference, social recognition, zebrafish S U PP O RTI N G I N FO R M ATI O NAdditional supporting information may be found online in the Supporting Information section.

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Section: Introductionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 77%

Oxytocin receptor signalling modulates novelty recognition but not social preference in zebrafish

Ribeiro

Nunes

Gliksberg

et al. 2020

J Neuroendocrinology

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“…Although OXT enhances affiliative behaviour in mammals [26,27], IT does not seem to promote affiliation in fishes [47,48,76]. Indeed, IT is associated with a reduction in affiliative tendencies in N. pulcher [45,49] and instead appears to enhance an individual's attention to social information [55,77], in line with the notion that OXT-related peptides promote the performance of socially salient behaviours [78].…”

Section: Discussionmentioning

confidence: 62%

“…Group members regularly engage in affiliative exchanges [44,45] and prefer familiar group members over size-matched groups of unfamiliar individuals [46], suggesting that affiliation among group members plays an important role in the rich social life of N. pulcher. Recently, isotocin (IT; the teleost homologue of OXT) has been implicated as a key regulator of affiliative behaviours in teleost fishes [47,48], including N. pulcher [45,49], suggesting the potential for IT to contribute to social buffering of stress in fishes through both behavioural and physiological effects.…”

Section: Introductionmentioning

confidence: 99%

Social buffering of stress in a group-living fish

2019

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Living in groups affords individuals many benefits, including the opportunity to reduce stress. In mammals, such ‘social buffering’ of stress is mediated by affiliative relationships and production of the neuropeptide oxytocin, but whether these mechanisms facilitate social buffering across vertebrates remains an open question. Therefore, we evaluated whether the social environment influenced the behavioural and physiological recovery from an acute stressor in a group-living cichlid, Neolamprologus pulcher . Individual fish that recovered with their social group displayed lower cortisol levels than individuals that recovered alone. This social buffering of the stress response was associated with a tendency towards lower transcript abundance of arginine vasotocin and isotocin in the preoptic area of the brain, suggesting reduced neural activation of the stress axis. Individuals that recovered with their social group quickly resumed normal behaviour but received fewer affiliative acts following the stressor. Further experiments revealed similar cortisol levels between individuals that recovered in visual contact with their own social group and those in visual contact with a novel but non-aggressive social group. Collectively, our results suggest that affiliation and familiarity per se do not mediate social buffering in this group-living cichlid, and the behavioural and physiological mechanisms responsible for social buffering may vary across vertebrates.

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“…Surprisingly, its selective blocker, the AVT V1a receptors blocker MC, instead of having an opposite outcome to the AVT agonist, yielded a similar effect. This is not the first time that AVT and MC have yielded an effect in the same direction: in zebrafish the two compounds decreased individuals' sociality (Lindeyer et al, 2015), while in the cleaner wrasse they decreased cleaning inspection durations of their clients (Soares et al, 2012). One po-…”

Section: Clients' Preference To Seek a Cleaner Proximitymentioning

confidence: 84%

The arginine-vasotocin and serotonergic systems affect interspecific social behaviour of client fish in marine cleaning mutualism

Triki

Bshary

Grutter

et al. 2017

Physiology & Behavior

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Many species engage in mutualistic relationships with other species. The physiological mechanisms that affect the course of such social interactions are little understood. In the cleaning mutualism, cleaner fish Labroides dimidiatus do not always act cooperatively by eating ectoparasites, but sometimes cheat by taking bites of mucus from so-called "client" reef fish. The physiological mechanisms in these interspecific interactions, however, are little studied. Here, we focussed on three neuromodulator systems known to play important roles in intraspecific social behaviour of vertebrates to examine their role in clients' interspecific behaviour. We subjected the client fish Scolopsis bilineatus to ectoparasites and the exogenous manipulation of the vasotocin (AVT), isotocin (IT) and serotonin systems to test how this affects client willingness to seek cleaning and client aggression towards cleaners. We found that a single dose of AVT agonist and a selective antagonist caused clients to seek proximity to cleaners, independently of ectoparasite infection. In contrast, in a direct encounter task, the selective blocker of serotonin 5HT receptors, Ketanserin (KET), made client reef fish more aggressive towards cleaners in the absence of cleaners' bites of mucus. IT did not yield any significant effects. Our results suggest that the AVT system plays a role in social affiliation towards an interspecific partner, while the serotonin system affects clients' acceptance of level of proximity to cleaner fish during interactions. These two systems, therefore, were apparently co-opted from intraspecific social interactions to affect the course of interspecific ones also.

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Nonapeptide influences on social behaviour: effects of vasotocin and isotocin on shoaling and interaction in zebrafish

Cited by 28 publications

References 55 publications

Oxytocin receptor signalling modulates novelty recognition but not social preference in zebrafish

Oxytocin receptor signalling modulates novelty recognition but not social preference in zebrafish

Social buffering of stress in a group-living fish

The arginine-vasotocin and serotonergic systems affect interspecific social behaviour of client fish in marine cleaning mutualism

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