Nonarteriosclerotic Disorders of the Arterial System

Moll, Stephan

doi:10.1016/b978-0-323-46202-0.00022-4

Cited by 2 publications

(1 citation statement)

References 79 publications

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“…Many vas cu lar abnor mal i ties with poten tial to pre cip i tate thrombus for ma tion have been reviewed in detail. 47 Such dis or ders may affect the artery wall (eg, dis sec tion, aneu rysm, fibromuscular dys pla sia, vas cu li tis) and/or cal i ber (eg, exter nal com pres sion, vaso spasm). Therefore, existing imag ing should be reviewed closely for ves sel abnor mal i ties.…”

Section: Vascular and Ana Tomic Dis Or Dersmentioning

confidence: 99%

Unexplained arterial thrombosis: approach to diagnosis and treatment

May

Moll

2021

Hematology

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Arterial thrombotic events in younger patients without a readily apparent etiology present significant diagnostic and management challenges. We present a structured approach to diagnosis with consideration of common causes, including atherosclerosis and embolism, as well as uncommon causes, including medications and substances, vascular and anatomic abnormalities, systemic disorders, and thrombophilias. We highlight areas of management that have evolved within the past 5 years, including the use of dual-pathway inhibition in atherosclerotic disease, antithrombotic therapy selection in embolic stroke of undetermined source and left ventricular thrombus, the role of closure of patent foramen ovale for secondary stroke prevention, and the thrombotic potential of coronavirus disease 2019 infection and vaccination. We conclude with a representative case to illustrate the application of the diagnostic framework and discuss the importance of consideration of bleeding risk and patient preference in determining the appropriate management plan.

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Section: Vascular and Ana Tomic Dis Or Dersmentioning

confidence: 99%

Unexplained arterial thrombosis: approach to diagnosis and treatment

May

Moll

2021

Hematology

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How I treat unexplained arterial thrombosis

May

Moll

2020

Blood

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Most arterial thrombotic events have a clear atherosclerotic or cardioembolic etiology, but hematologists are frequently asked to assist in the diagnosis and management of a patient with a non-atherosclerotic and non-cardioembolic arterial event, referred to herein as an unexplained arterial thrombosis. Because there is an assorted list of factors that can precipitate an arterial event, we present a systematic diagnostic approach to ensure consideration of not only primary hypercoagulable disorders, but also pro-thrombotic medications or substances, vascular and anatomic abnormalities, and undiagnosed systemic disorders, such as malignancy and autoimmune diseases. We also review existing literature of the role of hypercoagulable disorders in arterial thrombosis and discuss our approach to thrombophilia workup in patients after an unexplained arterial event. We conclude with three representative cases to both illustrate the application of the outlined diagnostic schema and discuss common management considerations, specifically the selection of anticoagulation versus anti-platelet therapy for secondary prevention.

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Nonarteriosclerotic Disorders of the Arterial System

Cited by 2 publications

References 79 publications

Unexplained arterial thrombosis: approach to diagnosis and treatment

Unexplained arterial thrombosis: approach to diagnosis and treatment

How I treat unexplained arterial thrombosis

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