Nonarteritic anterior ischemic optic neuropathy treated with intravenous prostaglandin E1 and steroids

Abstract

Intravenous PGE1 and steroids should be considered in cases of NAION to immediately restore blood flow to the optic nerve and improve visual acuity.

Bilateral Anterior Ischaemic Optic Neuropathy in a Child on Continuous Peritoneal Dialysis: Case report and literature review

“…12 Steroids and prostaglandins have also been reported to be effective. 25 The current patient was managed that the NAION was resolving with persistent bilateral disc pallor that was still more severe in the left eye compared to the right eye. Upon discharge, the patient's parents were advised of the importance of keeping their child hydrated and monitoring her BP in order to prevent further CPD complications.…”

Visual field improvement in non-arteritic posterior ischemic optic neuropathy in a patient treated with intravenous prostaglandin E1 and steroids

“…The use of a potent vasodilator, PGE1, to immediately re-establish blood flow could be important (3,7). PGE1 given intravenously at a dose of 1 μg/kg together with steroids has been successfully used to treat cases of NA-PION and acute non-arteritic anterior ischemic optic neuropathy (NA-AION) (4,5,8). PGE1 has helped in the treatment of acute arteritic anterior ischemic optic neuropathy when given with high-dose steroids (9).…”

Three episodes of non-arteritic posterior ischemic optic neuropathy in the same patient treated with intravenous prostaglandin E1

“…An extensive medical and ocular workup was not done before therapy with PGE1 since a delay in starting treatment could presumably lead to prolonged ischemia and possible permanent damage to the optic nerve. PGE1 has previously been reported to improve visual acuity in cases of NAION and AAION (4,5). In those cases, it was also given shortly after basic blood work and an EKG in order to immediately treat ischemia and avoid permanent damage to the optic nerve.…”

“…Intravenous PGE1 at a dose of 1 μg/kg and steroids have been used to treat acute non-arteritic anterior ischemic optic neuropathy (NA-AION) and acute arteritic AION (AAION) (4,5). Since NA-PION is a form of ischemia, PGE1 may help.…”