Nonbacterial thrombotic endocarditis involving all four cardiac valves

Kawada, Sachiko; Kuriyama, Motoaki; Kotani, Yasuhiro; Tsushima, Sho; Tanabe, Atsushi; Kioka, Yukio

doi:10.1177/0218492317748091

Cited by 6 publications

(7 citation statements)

References 6 publications

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“…The simultaneous quadri-valvular NBTE is very rare with only four cases, three in patients with cancer, being previously reported. 28,29 The distribution and extension of heart valve involvement by Ca-NBTE in our cohort are similar to those previously reported in autopsy studies 2,23,24 clinical series and meta-analysis of published case reports. 12,13 Eight (6.9%) of our patients had rightsided heart valves affected by NBTE with 4 cases limited only to the tricuspid valve.…”

Section: Discussionsupporting

confidence: 87%

“…One patient had three valves with NBTE, and one patient had all four heart valves affected by Ca‐NBTE. The simultaneous quadri‐valvular NBTE is very rare with only four cases, three in patients with cancer, being previously reported 28,29 . The distribution and extension of heart valve involvement by Ca‐NBTE in our cohort are similar to those previously reported in autopsy studies 2,23,24 clinical series and meta‐analysis of published case reports 12,13 .…”

Section: Discussionsupporting

confidence: 87%

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Cancer‐associated non‐bacterial thrombotic endocarditis—Clinical series from a single institution

Patrzalek,

Wysokinski,

Kurmann

et al. 2024

American J Hematol

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Premortem clinical presentation of cancer‐associated non‐bacterial thrombotic endocarditis (Ca‐NBTE), therapy, and the clinal course is limited to case reports and small clinical series. An electronic search of Mayo Clinic records (03/31/2002–06/30/2022) with a subsequent manual review was performed to identify adult patients with echocardiographically detected NBTE and active malignancy, excluding those with infectious endocarditis or lupus anticoagulant/antiphospholipid antibodies. In this retrospective cohort study, we analyzed 115 Ca‐NBTE patients (mean age 63.2 ± 9.7 years, 66.1% female) involving 71 (61.7%) mitral, 58 (50.4%) aortic, 8 (6.9%) tricuspid, and 1 (0.9%) pulmonary valve. The most common cancer was lung (n = 45 cases (39.1%), followed by pancreatic (n = 19, 16.5%), gynecological (17, 14.8%), gastrointestinal (n = 10, 8.7%), and 10 (8.7%) with hematologic malignancy; 6 patients had two active cancers. Embolic complications at presentation were frequent: 94 (81.7%) brain, 11 splenic, 10 renal, 6 coronary, and 4 to the extremities. Of 104 anticoagulated patients, 60 received low molecular weight heparin, 17 unfractionated heparin, 16 apixaban, 8 warfarin, and 3 rivaroxaban. There were 18 arterial thromboembolisms; the Kaplan–Meier estimates of the incidence at 2 years were consistent with a rate of 15.9% [95% Confidence Interval (CI) 9.9–23.3], including 14 strokes (12.4%, 95%CI, 7.1–19.2), and 8 other arterial emboli (10.5%, 95%CI, 4.7–18.9); there were 10 venous thromboembolisms (8.9%, 95%CI, 4.5–15.0). Fourteen major bleedings occurred (12.8%, 95%CI, 7.3–19.9) and 94 patients died during follow‐up (77.9%, 95%CI, 71.1–85.8). Ca‐NBTE predominantly affected women with lung adenocarcinoma or digestive tract cancers and manifested by stroke with high mortality and frequent embolic and bleeding complications during anticoagulation therapy.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

Cancer‐associated non‐bacterial thrombotic endocarditis—Clinical series from a single institution

Patrzalek,

Wysokinski,

Kurmann

et al. 2024

American J Hematol

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“…NBTE is a rare condition that is frequently underdiagnosed, despite being a dangerous manifestation of cancer-associated hypercoagulability because it is typically asymptomatic unless embolization occurs [ 8 ]. NBTE vegetations are aseptic, more fragile, and more prone to systemic embolization than infectious lesions [ 9 , 10 ]. Anatomically, the mitral valve (MV) is the most commonly affected, followed by the aortic valve (AV) [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Trivalvular nonbacterial thrombotic endocarditis in a patient with colon adenocarcinoma: a case report

Bagheri,

Khani,

Akbari

et al. 2023

J Med Case Reports

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Background Nonbacterial thrombotic endocarditis is a rare complication of prothrombotic states such as neoplasms that can cause valvular dysfunction and life-threatening complications. Nonbacterial thrombotic endocarditis usually affects the left-sided valves; however, only a minority of cases involving the tricuspid valve have been reported in medical literature. Case presentation The current report describes trivalvular involvement by nonbacterial thrombotic endocarditis in a 54-year-old Azeri female patient with metastatic colorectal carcinoma. This case underlines the necessity of evaluating nonbacterial thrombotic endocarditis as a possible consequence in cancer patients. When thromboembolic events are found in the presence of a hypercoagulable state (such as malignancy) and no growth on blood cultures, nonbacterial thrombotic endocarditis could be suspected as the cause. Conclusion It is critical to achieve early diagnosis in such a setting to initiate treatment plans and prevent further complications rapidly.

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“…Thrombus deposition must be present by definition in NBTE. There are only 6 cases of quadrivalvular NBTE reported in published reports, each with evidence of valvular thrombosis 3 , 4 , 5 , 6 , 7 , 8 . This report describes what the present authors believe to be the first description of a nonbacterial, nonthrombotic endocarditis of all 4 cardiac valves due to the deposition of IgM heavy chain.…”

Section: Discussionmentioning

confidence: 99%

Quadravalvular Noninfectious Endocarditis

et al. 2019

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Nonbacterial thrombotic endocarditis is characterized by sterile thrombi on cardiac valves. This report describes the case of nonbacterial endocarditis without pathologic findings of fibrin or platelet deposition. Quadrivalvular endocarditis was found to be due to immunoglobulin M heavy chain deposition. This was a case of nonbacterial, nonthrombotic quadrivalvular endocarditis, which was termed noninfective endocarditis. ( Level of Difficulty: Intermediate. )

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Nonbacterial thrombotic endocarditis involving all four cardiac valves

Cited by 6 publications

References 6 publications

Cancer‐associated non‐bacterial thrombotic endocarditis—Clinical series from a single institution

Cancer‐associated non‐bacterial thrombotic endocarditis—Clinical series from a single institution

Trivalvular nonbacterial thrombotic endocarditis in a patient with colon adenocarcinoma: a case report

Quadravalvular Noninfectious Endocarditis

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