Noncalcifying variant of calcifying epithelial odontogenic tumor with Langerhans cells

Tseng, Chia-Han; Wang, Yi Ping; Lee, Jang‐Jaer; Chang, Julia Yu Fong

doi:10.1016/j.jfma.2015.04.004

Cited by 29 publications

(17 citation statements)

References 4 publications

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“…As both oral and odontogenic epithelia originate from the same oral ectoderm, it is possible that LCs may also migrate into tumor odontogenic epithelial nests 6 . In this study, abundant LCs were found in the small tumor epithelial cell nests of noncalcifying and LC-rich CEOT 3, 4, 5, 6, 7, 8, 9. However, few LCs were discovered in sheets and large tumor epithelial cell nests of conventional CEOTs 8 .…”

Section: Discussionmentioning

confidence: 51%

“…When the noncalcifying and LC-rich CEOTs were compared with the conventional CEOTs, several characteristic features were noted. The noncalcifying and LC-rich CEOTs occurred only in Asian patients, had a predilection for the anterior and premolar region of the maxilla, had none of calcification foci in the tumor, contained small nests (or islands) and thin strands (or cords) of tumor odontogenic epithelial cells without marked cellular and nuclear pleomorphism, and showed a great number of LCs in the small tumor epithelial nests 3, 4, 5, 6, 7, 8, 9. However, the conventional CEOTs usually occurred in the posterior region of the jaw bone (especially the posterior region of the mandible), were often associated with an impacted tooth or an odontoma (∼60%), showed more or less calcified structures with some forming the Liesegang ring calcifications in the tumor stroma, contained sheets or relatively-large islands of polyhedral tumor odontogenic epithelial cells with prominent intercellular bridges, cellular and nuclear pleomorphism, and giant cell formation, and exhibited none or a very small number of LCs in the tumor epithelial nests 1, 8, 10, 11…”

Section: Discussionmentioning

confidence: 99%

“…The search was made using the keywords “calcifying epithelial odontogenic tumor”, “noncalcifying variant” and “Langerhans cell”. In total, nine accepted cases retrieved from seven articles were selected 3, 4, 5, 6, 7, 8, 9. The LC-containing conventional CEOT were excluded from the study samples.…”

Section: Methodsmentioning

confidence: 99%

“…The conventional CEOT has more or less foci of calcification. Another variant of CEOT that does not contain structures of calcification within the tumor is reported to be noncalcifying variant of CEOT with LCs 3, 4, 5, 6, 7, 8, 9. Although the tumor nests of conventional CEOT may occasionally contain LCs, the LC to tumor epithelial cell ratio is ∼ 0.8–1.7:100.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, we classed this specific type of noncalcifying variant of CEOT with LCs as noncalcifying and LC-rich variant of CEOT. In this study, nine cases of noncalcifying and LC-rich variant of CEOT were collected from the English literature 3, 4, 5, 6, 7, 8, 9. The clinical, radiographic, and histological features as well as treatment and prognosis of these nine cases of noncalcifying and LC-rich CEOT were analyzed and described in this study.…”

Section: Introductionmentioning

confidence: 99%

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Non-calcifying and Langerhans cell-rich variant of calcifying epithelial odontogenic tumor

Lin

Kuo

et al. 2016

Journal of Dental Sciences

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This study reported the clinicopathological features, treatment and prognosis of nine cases of noncalcifying and Langerhans cell (LC)-rich calcifying epithelial odontogenic tumor (CEOT) collected from the English literature. Of the nine cases, seven were intraosseous and two were extraosseous. All nine tumors were found in Asian patients. The age of the nine patients ranged from 20 years to 58 years with a mean age of 41 years. There were five female and four male patients. The seven intraosseous cases included six in the anterior and premolar region of the maxilla and one in the posterior region and ascending ramus of the mandible. The two extraosseous cases were located at the upper lateral incisor and premolar gingivae, respectively. Of the seven intraosseous cases, five showed unilocular and two multilocular radiolucency without foci of calcification. Six of the seven intraosseous cases showed resorption of the tooth roots in the tumor-involved region. Histologically, noncalcifying and LC-rich CEOTs were composed of small nests and thin strands of tumor epithelial cells with a relatively high number of LCs among them. This was the reason why we classed these nine cases as noncalcifying and LC-rich CEOTs. Two extraosseous cases received total excision of the gingival mass. For the seven intraosseous cases, four accepted partial maxillectomy or mandibulectomy, two received total excision or enucleation, and one underwent curettage. The six cases with the follow-up information available showed no tumor recurrence after a follow-up period of 6 months to 10 years.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Non-calcifying and Langerhans cell-rich variant of calcifying epithelial odontogenic tumor

Lin

Kuo

et al. 2016

Journal of Dental Sciences

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Noncalcifying type of calcifying epithelial odontogenic tumor: A rare case report and literature review

Zouaghi

Garma

Slim

et al. 2023

Clinical Case Reports

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Key Clinical MessageThere has been a recent spike in reporting of noncalcifying variants of CEOT with the WHO 2022 classification of head and neck tumors. The present case describes a rare histopathological variant of CEOT of which a handful of cases have been reported.AbstractThis work aimed to report a rare case of noncalcifying type of Pindborg Tumor involving the right mandible. The absence of calcifications in the calcifying epithelial odontogenic tumor presents a diagnostic challenge and prognostic implications. A literature review of the 16 reported clinical cases of this scarce variant was performed.

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Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla

Santosh

McNamara

Kalmar

et al. 2018

Head and Neck Pathol

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Calcifying epithelial odontogenic tumor (CEOT) is an uncommon locally invasive epithelial odontogenic tumor of the jaws associated with amyloid production. Intraosseous presentations are most common and they frequently occur in the posterior mandible. A non-calcifying Langerhans cell-rich variant of CEOT (NCLC CEOT) has been described with predilection for the anterior maxilla. Interestingly, all reported cases of NCLC CEOT have occurred in Asian population. We present a case of a 43-year old Caucasian female with a large radiolucent lesion involving the left anterior maxilla with histologic features of NCLC CEOT. This is the first reported case of this rare variant of CEOT in a Caucasian individual.

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Noncalcifying variant of calcifying epithelial odontogenic tumor with Langerhans cells

Cited by 29 publications

References 4 publications

Non-calcifying and Langerhans cell-rich variant of calcifying epithelial odontogenic tumor

Non-calcifying and Langerhans cell-rich variant of calcifying epithelial odontogenic tumor

Noncalcifying type of calcifying epithelial odontogenic tumor: A rare case report and literature review

Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla

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