Noncancer life stresses in newly diagnosed cancer

Lehto, Ulla-Sisko; Ojanen, Markku; Väkevä, Anna; Aromaa, Arpo; Kellokumpu‐Lehtinen, Pirkko

doi:10.1007/s00520-008-0410-8

Cited by 15 publications

(27 citation statements)

References 38 publications

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“…When their effect on survival has been researched in isolation, no associations or negligible ones have been found [1,4,12]. However, life stressors have an impact on quality of life of cancer patients [9,14,21,22,24,25]. …”

Section: Introductionmentioning

confidence: 99%

“…Life events comprise stressors in the external or internal environment that may produce a stress or adaptation response [13,18,20]. Negative, undesirable events are important for health outcomes [9,13,14,21,22]. The psychobiological process in cancer [2,23] is supposed to be mediated by personal (including coping), medical, social, and life stress variables, and result in quality of life and survival.…”

Section: Introductionmentioning

confidence: 99%

“…It records the number of events and their perceived impact during the past year. Information of the life stress summary variables used is available in our previous paper [22]. To assess cumulative life stress, we calculated averages of each stressor summary variable during 2, 3, and 4 years.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Life Events on Survival of Patients with Localized Melanoma

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Dyba

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Psychother Psychosom

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Life Events on Survival of Patients with Localized Melanoma

Lehto

Ojanen

Dyba

et al. 2012

Psychother Psychosom

Self Cite

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“…In this study, newly diagnosed cancer patients reported that in the years preceding the cancer diagnosis they experienced acute and chronic life stresses as well as loss events and previous chronic illness. 62 The data demonstrating the role for psychological stress in the development of pathologies of aging and cancer are of special interest and importance. They indicate that natural approaches including stress management have the potential to influence the molecular pathways of aging, aging-associated disorders, and cancer.…”

Section: The Role Of Psychological Stressmentioning

confidence: 99%

Aging and Cancer: Converging Routes to Disease Prevention

Chobotova

2009

Integr Cancer Ther

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A ging is often associated with neurological and physical deterioration and the development of diseases, including Parkinson's, Alzheimer's, diabetes, cardiovascular diseases, and cancer. Cancer is one of the diseases that drastically diminish quality of life and life expectancy. Extensive research into the molecular mechanisms of both aging and cancer has demonstrated the interrelatedness of their biological pathways.The most important of these pathways are the ones activated by DNA damage, depletion of stem cells, oxidative stress, and psychological stress. These pathways initiate multiple cascades of molecular signals that crossreact with each other, thereby activating the regulators of aging and cancer. Of these, the most interesting are the regulators of metabolism that respond directly to nutrient and energy cues. It is now becoming possible to infer from this evidence that external factors have a direct role in regulating aging and cancer. These include diet, physical activity, and stress control. This article will assess recent evidence linking the mechanisms of aging and cancer as well as surveying research on the effectiveness of natural approaches affecting these mechanisms. Aging and Cancer: Converging Routes to Disease PreventionKatya Chobotova, DPhilAn integrative approach to the combined challenges of aging, cancer and stress is a necessary part of a global vision of wellness. Recent research into the mechanisms of aging, cancer and stress has established the biological links between these processes. Understanding these links is an important stepping-stone for developing approaches and therapies that ensure wellness throughout all stages of aging. This paper will consider the most recent developments in research into the molecular mechanisms common to aging and cancer and will discuss the effectiveness of natural approaches for preventing disease. Metabolic regulators as well as nutrient and energy sensors are involved in the processes of aging and cancer, and these are open to external manipulation and control. It is now becoming possible to demonstrate how nutrition, physical activity and stress control can lead to disease-free aging.

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“…Many of the patients diagnosed with PCa choose to undergo surgical treatment. The anxiety of cancer diagnosis coupled with the side effect profile associated with surgical treatment impact the male's Clinical Urology Clinical Urology psychological state (2,3). Prostate cancer surgery will result in variable degrees of impaired urinary control and sexual dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Altered male physiologic function after surgery for prostate cancer: couple perspective

et al. 2009

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Purpose: Both the diagnosis of prostate cancer (PCa) and the physiologic outcomes of surgical treatment impact the male's psychological sphere. However, current research advocates a refocusing of outcomes directed to the PCa "couple". Herein we acquire insight into perspective and concordance regarding male physiological function from the standpoint of a couple recovering from PCa surgery. Materials and Methods: Couples whereby the male partner had undergone primary surgical treatment for PCa were mailed a Retrospective Sexual Survey (RSS) packet consisting of male and female partner questionnaires. RSS questions surveyed physiological changes in libido, foreplay, erection and arousal, orgasm and ejaculation in addition to perceived psychological impact. Patients' and partners' scores were evaluated to determine the concordance of both individual items as well as domain sums. Results: Twenty-eight couples completed the questionnaires. Only about 40% of men and women were happy with their levels of sexual interest with 82% concordance. Urine loss during orgasm was reported by 43% of men; the majority of participants were bothered by it. Ejaculation changes were observed by 96% of men (concordance 96%) with most reporting anejaculation. A change in orgasm experience was noted by 86% of men (and 36% of their female partners, p < 0.0001). Despite the change, the majority of men and women reported being satisfied with their ability to climax. Conclusion: Our results indicate that patients and their female partners may interpret differently the same physiological outcomes of PCa surgery. This information could be useful to better counsel the PCa couple and help patients and partners adjust after surgery.

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Noncancer life stresses in newly diagnosed cancer

Abstract: Noncancer life stresses are common among newly diagnosed cancer patients and have impact on QOL, and thus they should be taken into account in cancer care. Screening for noncancer life stresses may offer means to enhance QOL outcomes in cancer.

Cited by 15 publications

References 38 publications

Impact of Life Events on Survival of Patients with Localized Melanoma

Impact of Life Events on Survival of Patients with Localized Melanoma

Aging and Cancer: Converging Routes to Disease Prevention

Altered male physiologic function after surgery for prostate cancer: couple perspective

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