Noncatalytic regulation of 18<i>S</i>rRNA methyltransferase DIMT1 in acute myeloid leukemia

Gonskikh, Yulia; Stoute, Julian; Shen, Hui; Budinich, Krista A.; Pingul, Bianca; Schultz, Kollin; Elashal, Heidi; Marmorstein, Ronen; Shi, Junwei; Liu, Kathy Fange

doi:10.1101/gad.350298.122

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…After DIMT1 eliminated, ribosome profiling of AML cells showed dysregulated transcript subsets, indicating that DIMT1 may influence a variety of cancer pathways and malignancies, including leukemia. 79 Our findings indicated that DIMT3 gene expression was lower in AML patients as compared to the control group, which is similar to results in the literature. RPL17-C18orf32 , another ribosomal protein, was decreased in AML patients with high beta-catenin levels, compared to the control group in our study for the first time.…”

Section: Discussionsupporting

confidence: 91%

Transcriptome analysis of beta-catenin-related genes in CD34+ haematopoietic stem and progenitor cells from patients with AML

Altinok Gunes,

OZKAN,

Karadag Gurel

et al. 2024

Mediterr J Hematol Infect Dis

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Background: Acute myeloid leukaemia(AML) is a disease of the haematopoietic stem cells. Beta-catenin, a key element of the Wnt signalling, which is particularly active in various cancers. Our aim of this study was to determine beta-catenin gene expression levels in AML patients. Then, it is planned to compare the genes between AML grouped according to beta-catenin gene expression levels by DNA microarray. When the gene group identified in this way is combined with the genes in the control group, the aim is to determine the genes that are associated with beta-catenin in AML. Methods: In this study, beta-catenin gene expression levels were determined in 19 AML patients and 3 controls by qRT-PCR. Transcriptome analysis was performed on AML grouped according to beta-catenin expression levels. Differentially expressed genes(DEGs) were identified and investigated with using DAVID, GO, KEGG and STRING. Results: The transcriptome profiles of our AML samples showed different molecular signature profiles according on their beta-catenin levels(high-low). A total of 20 genes have been identified as hub genes. Among these, TTK, HJURP, KIF14 and BTF3, RPL17, RSL1D1 were found to be associated with poor survival and suggested to be associated with beta-catenin in AML. Furthermore, for the first time in our study, the ELOV6 gene, which is the most highly up-regulated gene in human AML samples, was correlated with a poor prognosis via beta-catenin high levels. Conclusion: It is suggested that the identification of beta-catenin-related gene profiles in AML may help to select new therapeutic targets for the treatment of AML.

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Section: Discussionsupporting

confidence: 91%

Transcriptome analysis of beta-catenin-related genes in CD34+ haematopoietic stem and progenitor cells from patients with AML

Altinok Gunes,

OZKAN,

Karadag Gurel

et al. 2024

Mediterr J Hematol Infect Dis

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Phase Separation of Chromatin Structure-related Biomolecules: A Driving Force for Epigenetic Regulations

Wang,

Chen,

Xiao

et al. 2024

CPPS

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Intracellularly, membrane-less organelles are formed by spontaneous fusion and fission of macro-molecules in a process called phase separation, which plays an essential role in cellular activities. In certain disease states, such as cancers and neurodegenerative diseases, aberrant phase separations take place and participate in disease progression. Chromatin structure-related proteins, based on their characteristics and upon external stimuli, phase separate to exert functions like genome assembly, transcription regulation, and signal transduction. Moreover, many chromatin structure-related proteins, such as histones, histone-modifying enzymes, DNA-modifying enzymes, and DNA methylation binding proteins, are involved in epigenetic regulations through phase separation. This review introduces phase separation and how phase separation affects epigenetics with a focus on chromatin structure-related molecules.

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Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia

Cited by 2 publications

References 47 publications

Transcriptome analysis of beta-catenin-related genes in CD34+ haematopoietic stem and progenitor cells from patients with AML

Transcriptome analysis of beta-catenin-related genes in CD34+ haematopoietic stem and progenitor cells from patients with AML

Phase Separation of Chromatin Structure-related Biomolecules: A Driving Force for Epigenetic Regulations

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