Nonclinical Investigation of Cytokine Mitigation Strategies for T-cell–Engaging Bispecifics in the Cynomolgus Macaque
Cris Kamperschroer,
Magali Guffroy,
Amy Shen
et al.
Abstract:Summary
T-cell–directed cancer therapies such as T-cell–engaging bispecifics (TCBs) are commonly associated with cytokine release syndrome and associated clinical signs that can limit their tolerability and therapeutic benefit. Strategies for reducing cytokine release are therefore needed. Here, we report on studies performed in cynomolgus monkeys to test different approaches for mitigating cytokine release with TCBs. A “priming dose” as well as subcutaneous dosing reduced cytokine release compared… Show more
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