Noncoding RNAs in the Glycolysis of Ovarian Cancer

Zhang, Chunmei; Liu, Ning

doi:10.3389/fphar.2022.855488

Cited by 15 publications

(10 citation statements)

References 171 publications

(180 reference statements)

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“…Afterward, “Study of cancer cell apoptosis pathway (cluster 1)” progressively gained importance around 2014, and some areas remain the hotpots until today, for example, “androgen receptor” (APY = 2018.82) ( 103 ), “glioblastoma” (APY= 2018.54) ( 79 ), and “transcription” (APY= 2018.15) ( 104 ). Notably, cluster 3 and cluster 5 (“study of cancer stem cells and autophagy”) are the two clusters that had the smallest APY compared with other clusters, and “metabolic reprogramming” (APY= 2019.39) ( 105 ), “microRNAs” (APY= 2019.05) ( 106 ) were mainly found lately. This implies that these two clusters are emerging topics in recent years, and more related research may be published in the future.…”

Section: Resultsmentioning

confidence: 99%

Trends in metabolic signaling pathways of tumor drug resistance: A scientometric analysis

et al. 2022

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BackgroundCancer chemotherapy resistance is one of the most critical obstacles in cancer therapy. Since Warburg O first observed alterations in cancer metabolism in the 1950s, people gradually found tumor metabolism pathways play a fundamental role in regulating the response to chemotherapeutic drugs, and the attempts of targeting tumor energetics have shown promising preclinical outcomes in recent years. This study aimed to summarize the knowledge structure and identify emerging trends and potential hotspots in metabolic signaling pathways of tumor drug resistance research.MethodsPublications related to metabolic signaling pathways of tumor drug resistance published from 1992 to 2022 were retrieved from the Web of Science Core Collection database. The document type was set to articles or reviews with language restriction to English. Two different scientometric software including Citespace and VOS viewer were used to conduct this scientometric analysis.ResultsA total of 2,537 publications including 1,704 articles and 833 reviews were retrieved in the final analysis. The USA made the most contributions to this field. The leading institution was the University of Texas MD Anderson Cancer Center. Avan A was the most productive author, and Hanahan D was the key researcher with the most co-citations, but there is no leader in this field yet. Cancers was the most influential academic journal, and Oncology was the most popular research field. Based on keywords occurrence analysis, these selected keywords could be roughly divided into five main topics: cluster 1 (study of cancer cell apoptosis pathway); cluster 2 (study of resistance mechanisms of different cancer types); cluster 3 (study of cancer stem cells); cluster 4 (study of tumor oxidative stress and inflammation signaling pathways); and cluster 5 (study of autophagy). The keywords burst detection identified several keywords as new research hotspots, including “tumor microenvironment,” “invasion,” and “target”.ConclusionTumor metabolic reprogramming of drug resistance research is advancing rapidly. This study serves as a starting point, providing a thorough overview, the development landscape, and future opportunities in this field.

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Section: Resultsmentioning

confidence: 99%

Trends in metabolic signaling pathways of tumor drug resistance: A scientometric analysis

et al. 2022

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“…MiRNAs serve as a key regulator of mRNA expression at the post-transcription level, and miRNAs are widely dysregulated in various types of cancer cells (Hill and Tran, 2021). A recent study supported that miRNAs control cancer-associated glycolytic processes through interaction with the key enzymes of glycolysis and cellular signaling pathway in cancers such as ovarian cancer (Zhang and Liu, 2022). For example, the expression of miR-203 is increased in ovarian cancer and promotes aerobic glycolysis by directly targeting the pyruvate dehydrogenase B (Zhao et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

MiR-194-5p suppresses the warburg effect in ovarian cancer cells through the IGF1R/PI3K/AKT axis

DU¹,

Dou²,

LIANG³

et al. 2023

Biocell

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Background: The Warburg effect is considered as a hallmark of various types of cancers, while the regulatory mechanism is poorly understood. Our previous study demonstrated that miR-194-5p directly targets and regulates insulin-like growth factor1 receptor (IGF1R). In this study, we aimed to investigate the role of miR-194-5p in the regulation of the Warburg effect in ovarian cancer cells. Methods: The stable ovarian cell lines with miR-194-5p overexpression or silencing IGF1R expression were established by lentivirus infection. ATP generation, glucose uptake, lactate production and extracellular acidification rate (ECAR) assay were used to analyze the effects of aerobic glycolysis in ovarian cancer cells. Gene expression was analyzed by quantitative polymerase chain reaction (qPCR) and western blot. Immunohistochemistry assays were performed to assess the expression of the IGF1R protein in ovarian cancer tissues. Results: Overexpression of miR-194-5p or silencing IGF1R expression in ovarian cancer cells decreases ATP generation, glucose uptake, lactate production, and ECAR and inhibits both the mRNA and protein expression of PKM2, LDHA, GLUT1, and GLUT3. While the knockdown of miR-194-5p expression led to opposite results.Overexpression of miR-194-5p or silencing IGF1R expression suppressed the phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) pathway, whose activation can sustain aerobic glycolysis in cancer cells, and the knockdown of miR-194-5p expression promoted the activation of the PI3K/AKT pathway. Conclusion: Our results suggest that miR-194-5p can inhibit the Warburg effect by negative regulation of IGF1R and further repression of the PI3K/AKT pathway, which provides a theoretical basis for further test of miR-194-5p as a target in the treatment of ovarian cancer.

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“…By contrast, the 5-year survival rates of patients diagnosed with stage I or II disease are as high as 70-90% (9). At present, tumor resection combined with platinum chemotherapy is the standard treatment option for ovarian cancer (10). Surgical tumor reduction combined with platinum and taxane chemotherapy may lead to clinical remission in up to 75% of cases (8).…”

Section: Introductionmentioning

confidence: 99%

Role of microRNAs in glycolysis in gynecological tumors (Review)

Chen

Shen

et al. 2023

Int J Oncol

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Gynecological malignancies are a leading cause of mortality among females worldwide, and difficulties in early diagnosis and acquired drug resistance constitute obstacles to effective therapies. Ovarian cancer causes more deaths than any other cancer of the female reproductive system. Specifically, in females aged 20 to 39 years, cervical cancer is the third leading cause of cancer-related mortality, and the incidence rates of cervical adenocarcinoma are increasing. Endometrial carcinoma is the most common gynecological cancer in developed countries, such as the United States. Vulvar cancer and uterine sarcomas are considered rare, and therefore require further investigation. Notably, the development of novel treatment options is critical. Previous research has revealed metabolic reprogramming as a distinct feature of tumor cells, which includes aerobic glycolysis. In this instance, cells produce adenosine triphosphate and various precursor molecules through glycolysis, despite oxygen levels being sufficient. This is to meet the energy required for rapid DNA replication. This phenomenon is also known as the Warburg effect. The Warburg effect results in an increased glucose uptake, lactate production and reduced pH values in tumor cells. The results of previous studies have demonstrated that microRNAs (miRNAs/miRs) regulate glycolysis, and participate in tumorigenesis and tumor progression via interactions with glucose transporters, essential enzymes, tumor suppressor genes, transcription factors and multiple cellular signaling pathways that play critical roles in glycolysis. Notably, miRNAs affect the levels of glycolysis in ovarian, cervical and endometrial cancers. The present review article provides a comprehensive overview of the literature surrounding miRNAs in the glycolysis of gynecological malignant cells. The present review also aimed to determine the role of miRNAs as potential therapeutic options rather than diagnostic markers. Contents1. Introduction 2. miRNAs and the Warburg effect 3. miRNAs and glycolysis 4. miRNAs and glycolysis in gynecological cancers 5. Conclusions and future perspectives

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Noncoding RNAs in the Glycolysis of Ovarian Cancer

Cited by 15 publications

References 171 publications

Trends in metabolic signaling pathways of tumor drug resistance: A scientometric analysis

Trends in metabolic signaling pathways of tumor drug resistance: A scientometric analysis

MiR-194-5p suppresses the warburg effect in ovarian cancer cells through the IGF1R/PI3K/AKT axis

Role of microRNAs in glycolysis in gynecological tumors (Review)

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