Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance

Hu, M.; Li, Juan; Liu, Chen-Guang; Goh, Robby Miguel; Yu, F.; Ma, Zhaowu; Wang, Lingzhi

doi:10.3390/cells11060947

Cited by 9 publications

(9 citation statements)

References 141 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results support existing data by showing that cancer cells reprogram their surroundings into a tumor-promoting microenvironment via the secretion of EVs [ 57 ]. In order to create their own vascular system, tumors change their microenvironment from an antiangiogenic to a proangiogenic one via a process termed “angiogenic switch” [ 29 , 58 ]. Our report supports the premise that EVs may be specifically involved in such a cancer-related angiogenic switch; moreover, this is the first study to demonstrate the role of GC-EVs in this process.…”

Section: Discussionmentioning

confidence: 99%

“…These effects are mediated by the content of EVs, including RNA (mRNA, miRNA, and other RNAs), proteins, and lipids [ 26 , 27 ]. While knowledge on the role of tumor-derived EVs in angiogenesis is expanding [ 28 , 29 ], research on the role of GC-derived EVs (GC-EVs) in angiogenesis is still in its early stages and mainly focuses on EVs-derived miRNA [ 30 , 31 ]. We characterized the angiogenic protein content of GC-EVs, demonstrating their proangiogenic in vivo and in vitro effects, specifically through ANG2.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gastric Cancer-Derived Extracellular Vesicles (EVs) Promote Angiogenesis via Angiopoietin-2

Kalfon

Loewenstein

Gerstenhaber

et al. 2022

Cancers

View full text Add to dashboard Cite

Angiogenesis is an important control point of gastric cancer (GC) progression and metastasis. Angiopoietin-2 (ANG2) is a key driver of tumor angiogenesis and metastasis, and it has been identified in primary GC tissues. Extracellular vesicles (EVs) play an important role in mediating intercellular communication through the transfer of proteins between cells. However, the expression of ANG2 in GC-EVs has never been reported. Here, we characterized the EV-mediated crosstalk between GC and endothelial cells (ECs), with particular focus on the role of ANG2. We first demonstrate that ANG2 is expressed in GC primary and metastatic tissues. We then isolated EVs from two different GC cell lines and showed that these EVs enhance EC proliferation, migration, invasion, and tube formation in vitro and in vivo. Using an angiogenesis protein array, we showed that GC-EVs contain high levels of proangiogenic proteins, including ANG2. Lastly, using Lenti viral ANG2-shRNA, we demonstrated that the proangiogenic effects of the GC-EVs were mediated by ANG2 through the activation of the PI3K/Akt signal transduction pathway. Our data suggest a new mechanism via which GC cells induce angiogenesis. This knowledge may be utilized to develop new therapies in gastric cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gastric Cancer-Derived Extracellular Vesicles (EVs) Promote Angiogenesis via Angiopoietin-2

Kalfon

Loewenstein

Gerstenhaber

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…In addition, EVs circRNAs can modulate the permeability of endothelial cells, thereby facilitating the metastasis of cancer cells 32 . In conclusion, various RNAs in EVs play important regulatory roles in angiogenesis by targeting different molecules 33 …”

Section: Evs Affect Various Processes Of Npcmentioning

confidence: 97%

The role of extracellular vesicles in the development of nasopharyngeal carcinoma and potential clinical applications

et al. 2023

View full text Add to dashboard Cite

Background: Extracellular vesicles (EVs) can be secreted by a wide variety of cells, including tumor cells, and contain some bioactive molecules from the source cells. Therefore, they can potentially be used as biomarkers for early diagnosis of tumors and for tumor therapy. In addition, EVs can affect the features of target cells and participate in regulating the development process of tumors. Methods:A literature review was conducted to elucidate the role of extracellular vesicles in the progression and treatment of nasopharyngeal carcinoma. Results:In this review, we discuss the molecular mechanisms of cell proliferation, angiogenesis, epithelial-mesenchymal transformation and metastasis, immune response, and chemo-radiotherapy resistance that are induced by EVs. We also reviewed the potential applications of EVs as biomarkers, therapeutic agents, and carriers so as to determine new directions for the early diagnosis and targeted therapy of nasopharyngeal carcinoma. The application limitations have also been discussed in this review, further work is needed to ensure optimal outcomes for patients. Conclusion:Although the roles of extracellular vesicles in the progression of nasopharyngeal carcinoma have been summarized, some aspects are still unclear and need to be further studied. In addition, the applications of extracellular vesicles in the treatment of nasopharyngeal carcinoma still need to optimize conditions to produce better therapeutic outcomes for patients with nasopharyngeal carcinoma.

show abstract

“…Other studies have shown that dendritic cells take up circulating EVs from other dendritic cells, and their cargo proteins are processed and presented as antigens, playing a role in immune regulation [ 33 , 34 ]. Among other pathological conditions they are involved in, cancer has received the most attention [ 35 , 36 ], but EVs also play a role in neurodegenerative diseases such as Alzheimer’s [ 37 ] and cardiovascular diseases such as atherosclerosis [ 38 ], as well as infectious diseases such as HIV-1 infection [ 39 ].…”

Section: The Interest Of Evs In Solid Organ Transplantationmentioning

confidence: 99%

Extracellular Vesicles: The Future of Diagnosis in Solid Organ Transplantation?

Romero-García

Huete-Acevedo

Mas-Bargues

et al. 2023

IJMS

View full text Add to dashboard Cite

Solid organ transplantation (SOT) is a life-saving treatment for end-stage organ failure, but it comes with several challenges, the most important of which is the existing gap between the need for transplants and organ availability. One of the main concerns in this regard is the lack of accurate non-invasive biomarkers to monitor the status of a transplanted organ. Extracellular vesicles (EVs) have recently emerged as a promising source of biomarkers for various diseases. In the context of SOT, EVs have been shown to be involved in the communication between donor and recipient cells and may carry valuable information about the function of an allograft. This has led to an increasing interest in exploring the use of EVs for the preoperative assessment of organs, early postoperative monitoring of graft function, or the diagnosis of rejection, infection, ischemia-reperfusion injury, or drug toxicity. In this review, we summarize recent evidence on the use of EVs as biomarkers for these conditions and discuss their applicability in the clinical setting.

show abstract

Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance

Cited by 9 publications

References 141 publications

Gastric Cancer-Derived Extracellular Vesicles (EVs) Promote Angiogenesis via Angiopoietin-2

Gastric Cancer-Derived Extracellular Vesicles (EVs) Promote Angiogenesis via Angiopoietin-2

The role of extracellular vesicles in the development of nasopharyngeal carcinoma and potential clinical applications

Extracellular Vesicles: The Future of Diagnosis in Solid Organ Transplantation?

Contact Info

Product

Resources

About