Noncoding RNAs Regulating Cancer Signaling Network

Hu, Jing; Markowitz, Geoffrey J.; Wang, Xiaofan

doi:10.1007/978-981-10-1498-7_11

Cited by 5 publications

(3 citation statements)

References 94 publications

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“…It is well known that miRNAs can regulate downstream signal pathways, activating or blocking downstream effector molecular signal transduction, through affecting the key genes expression in cancer ( 28 , 29 ). With the deepening of research in recent years, miRNA has the ability to participate in cell proliferation, apoptosis, migration, invasion and other physiological processes, which have been confirmed ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

MiR-103a-3p Promotes Tumorigenesis of Breast Cancer by Targeting ETNK1

Li,

Qiu,

Shi

2024

ijph

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Background: We aimed to elucidate the molecular mechanism of miR-103a-3p regulating breast cancer progression. Methods: Firstly, clinical tissues was obtained from 2019-2023 at Yancheng Third People's Hospital, Yancheng, China. miR-103a-3p or ETNK1 expression in clinical tissues or breast cancer cell lines was analyzed with qRT-PCR. MDA-MB-231 cells were performed with miR-103a-3p inhibitor or mimic, and OE-ETNK1. The proliferation and apoptosis ability were detected by CCK-8 and TUNEL assay. The xenograft models were established by inoculating transfected MDA-MB-231 cells to BALB/c mice. Results: miR-103a-3p showed an overexpression and was related to poor prognosis in breast cancer. miR-103a-3p-deprived MDA-MB-231 cells displayed weaker levels of cell proliferation and higher rates of apoptosis. In contrast, ETNK1 was downregulated in breast cancer and proved to be a downstream target of miR-103a-3p. Xenograft models subjected to either miR-103a-3p antagomir treatment or ETNK1-knockdown resulted in tumor growth suppression. Conclusion: miR-103a-3p might promote breast cancer progression by inhibiting ETNK1.

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Section: Discussionmentioning

confidence: 99%

MiR-103a-3p Promotes Tumorigenesis of Breast Cancer by Targeting ETNK1

Li,

Qiu,

Shi

2024

ijph

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“…miRNAs can positively or negatively regulate signaling pathways, promoting or preventing signal transmission to downstream effectors. Multiple studies have demonstrated that miRNAs play key functions in tumorigenesis by regulating tumor suppressors or oncogenes (108,109). Over the past decade, research on the pathogenesis of BC has led to the discovery of a number of signaling pathways and corresponding therapeutic targets involved in BC, such as transforming growth factor β (110,111), phosphoinositide-3-kinase (PI3K), v-akt murine thymoma viral oncogene homolog (AKT), mechanistic target of rapamycin (mTOR) (112)(113)(114), Ras/mitogen-activated protein kinase (MAPK) (115,116), nuclear factor (NF)-κB (117)(118)(119)(120), Notch (121)(122)(123), Wnt/β (124,125), HER2 (126), vascular endothelial growth factor (VEGF) (127,128), epidermal growth factor receptor (EGFR) (129,130), cyclin-dependent kinase 4/6 (CDK4/6) (131), poly(adenosine diphosphate-ribose) polymerase (PARP) (132,133) and programmed death-1 (PD-1) (134).…”

Section: Mirnas and Various Signaling Pathways And Therapeutic Target...mentioning

confidence: 99%

miRNAs as potential markers for breast cancer and regulators of tumorigenesis and progression (Review)

Zhang

Qiu

et al. 2021

Int J Oncol

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Breast cancer (BC) is one of the most common malignancies affecting women. BC is a heterogeneous disease that involves multiple oncogenic pathways and/or genetic alterations. MicroRNAs (miRNAs or miRs) are a type of small endogenous single-stranded RNA that pairs with the 3'untranslated region of target mRNAs to negatively regulate the gene expression of specific mRNA targets. miRNAs are thus involved in various cellular processes, including proliferation, differentiation, apoptosis, migration, metabolism and the stress response. Over the past decade, a number of studies have demonstrated that the expression levels of miRNAs are dysregulated in a number of types of cancer, including BC.In the present review, recent research on miRNAs involved in the occurrence and development of BC, as well as the current findings on miRNAs as potential biomarkers for BC are summarized. In addition, the association between miRNA dysregulation and BC development, and the current status of BC treatment and prognosis are discussed. Finally, several signaling pathways involved in the development of BC and the potential roles of miRNAs in these pathways are reviewed. The present review aims to provide insight into the roles of miRNAs in BC. Contents1. Introduction 2. Potential biomarkers in BC 3. miRNA dysregulation in BC 4. miRNAs as therapeutic targets of BC 5. miRNAs and various signaling pathways, and therapeutic targets involved in BC 6. Summary and future perspectives

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“…Multigene regulatory features of these small RNA molecules allow them to change signaling pathways, facilitate or block signal transmission to downstream effectors in various ways. MiRNAs can regulate key signaling pathways positively or negatively, therefore they can affect tumorigenesis (Hu, Markowitz, & Wang, ; Zarredar et al, ). Various signaling pathways have been elucidated in the cell, most of them are important to a cascade of biological events and gene expression.…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs in breast cancer: Roles, functions, and mechanism of actions

Abolghasemi

Tehrani

Yousefi

et al. 2019

Journal Cellular Physiology

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Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor‐κ B, phosphoinositide‐3‐kinase/Akt, and extracellular‐signal‐regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer.

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Noncoding RNAs Regulating Cancer Signaling Network

Cited by 5 publications

References 94 publications

MiR-103a-3p Promotes Tumorigenesis of Breast Cancer by Targeting ETNK1

MiR-103a-3p Promotes Tumorigenesis of Breast Cancer by Targeting ETNK1

miRNAs as potential markers for breast cancer and regulators of tumorigenesis and progression (Review)

MicroRNAs in breast cancer: Roles, functions, and mechanism of actions

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