Noncompliance in children with renal transplants

Korsch, Barbara M.; Fine, Richard Ν.; Negrete, Vida Francis

doi:10.1016/s0002-7138(09)60492-1

Cited by 50 publications

(100 citation statements)

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“…Consistent with other studies in the child and adolescent population, we found evidence of nonadherence in our subjects at both interviews (11)(12)(13)(14). Several studies have examined nonadherence with medications among children and adolescents and report widely varying rates, ranging from 18% to 69% (8)(9)(10)13,14,71). Although differences in methodologies employed to assess medication nonadherence makes meaningful comparisons difficult, our rates of 13.6% at each of the two interviews appear to be less than the lower end of this range.…”

Section: Discussionsupporting

confidence: 91%

“…Among the leading causes of graft loss is nonadherence with the post-transplant treatment regimen (4)(5)(6), accounting for as much as 78% of graft loss (7). Studies that include children and adolescents indicate that adolescents are at greater risk than younger children for nonadherence, with rates as high as 64% (8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Psychological Distress and Adherence to the Medical Regimen Among Adolescent Renal Transplant Recipients

Penkower¹,

Dew²,

Ellis³

et al. 2003

American Journal of Transplantation

105

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This longitudinal pilot study of adolescent renal transplant recipients (a) describes the prevalence of psychological distress, (b) describes the prevalence of nonadherence, and (c) explores the association between the recipient's psychological distress and his/her subsequent medical adherence. Twenty-two adolescents, aged 13-18 years, completed two interviews that were separated by approximately 12 months. Psychological distress was assessed in three domains: symptoms of depression, anxiety, and anger. Adherence was assessed in three domains: medication taking, blood work, and clinic attendance. At the initial interview, 36.4% had symptoms of depression, 36.4% endorsed anxiety, and 18.2% endorsed excessive state anger. Non-adherence rates were 13.6% for medication, 22.7% for blood work, and 50% for missed clinic. At the second interview, nonadherence with medication remained the same and the other domains decreased. Our small pilot sample, however, limited our ability to detect statistically significant changes over time. Predictive analyses demonstrated that adolescents with excessive anger were at greater risk for subsequently missing medications than adolescents without excessive anger. These findings suggest that while symptoms of depression and anxiety are observed among some adolescents with renal transplants, only anger is associated with elevated risk for nonadherence with medication.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Psychological Distress and Adherence to the Medical Regimen Among Adolescent Renal Transplant Recipients

Penkower¹,

Dew²,

Ellis³

et al. 2003

American Journal of Transplantation

105

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“…Studies of chronic disease indicate that patients decrease adherence as symptoms and side effects occur. 9,35,[55][56][57][58] Side effects from the disease and/or the treatment of cancer may also affects adherence. 9,33 Given and colleagues 24 recently conducted an intervention study finding symptom management improved adherence.…”

Section: Disease Factorsmentioning

confidence: 99%

The Challenges of Oral Agents as Antineoplastic Treatments

Given

Spoelstra²,

Grant³

2011

Seminars in Oncology Nursing

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“…Studies of cancer and non-cancer diseases indicate that patients decrease adherence as symptoms and side effects occur. 73,[81][82][83][84][85] Few studies to date have linked symptom severity with nonadherence 86 and further study is needed. Adherence is inversely related to medication regimen complexity 87 Incorporating a medication calendar into each study is imperative.…”

Section: Patient Characteristics Contributing To Adherence and Implicmentioning

confidence: 99%

Assessment and Measurement of Adherence to Oral Antineoplastic Agents

Spoelstra¹,

Given²

2011

Seminars in Oncology Nursing

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OBJECTIVES:The increase in oral anticancer medications with complex regimens creates a need to assure patients are taking therapeutic dosages as prescribed. This article reviews the assessment and measurement of adherence to oral antineoplastic agents. DATA SOURCE:Research and journal articles from CINAHL and Pub Med. CONCLUSION:Assessing and measuring adherence to oral antineoplastic should include three dimensions: the percentage of medications taken, the duration, and the timing of taking the medication. IMPLICATIONS FOR PRACTICE:Clinicians need to conduct ongoing assessment and measurement of adherence to oral antineoplastic agents. This includes eliciting patient report of adherence, pill counts, drug diaries, and pharmacy or medical record audits.

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Noncompliance in children with renal transplants

Cited by 50 publications

References 0 publications

Psychological Distress and Adherence to the Medical Regimen Among Adolescent Renal Transplant Recipients

Psychological Distress and Adherence to the Medical Regimen Among Adolescent Renal Transplant Recipients

The Challenges of Oral Agents as Antineoplastic Treatments

Assessment and Measurement of Adherence to Oral Antineoplastic Agents

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