Noncontact Speckle Contrast Diffuse Correlation Tomography of Blood Flow Distributions in Burn Wounds: A Preliminary Study

Zhao, Mingjun; Mazdeyasna, Siavash; Huang, Chong; Agochukwu-Nwubah, Nneamaka; Bonaroti, Alisha R.; Wong, Lesley; Yu, Guoqiang

doi:10.1093/milmed/usz233

Cited by 19 publications

(22 citation statements)

References 18 publications

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“…Moreover, scDCT allows customization of the ROI for imaging different tissues/organs with varied scales/dimensions. We have recently demonstrated the feasibility of scDCT for 3D imaging of blood flow distributions in rodent brains [37], and in human wounds [71] and reconstructive skin flaps [35, 36].…”

Section: Discussionmentioning

confidence: 99%

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Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets

Huang

Mazdeyasna

Mohtasebi

et al. 2021

Journal of Biophotonics

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We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.

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Section: Discussionmentioning

confidence: 99%

“…In addition to this preclinical study, our scDCT has been tested for noninvasive imaging of human preterm brains [38] and human mastectomy skin flaps [36, 78, 79] with a penetration depth of ~10 mm. This depth (10 mm) enables penetrating deeply into human infant brains [38].…”

Section: Discussionmentioning

confidence: 99%

Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets

Huang

Mazdeyasna

Mohtasebi

et al. 2021

Journal of Biophotonics

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“…Functional near-infrared spectroscopy (fNIRS) is a noninvasive, functional neuroimaging technique that could assess brain function by quantifying cerebral oxygenation at the microvasculature level (6)(7)(8). After more than 40 years of development, this technology has been used for evaluation of cerebral function (9)(10)(11) and extended to the clinical field of psychiatry, as one of the objective modalities for probing psychoses (12). fNIRS is sensitive to external stimulation or events; it allows for longitudinal monitoring of the changes in brain metabolism.…”

Section: Introductionmentioning

confidence: 99%

Task and Non-task Brain Activation Differences for Assessment of Depression and Anxiety by fNIRS

et al. 2021

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Diagnosis and treatment of the patients with major depression (MD) or the combined anxiety and depression (A&D) depend on the questionnaire, sometimes accompanied by tasks such as verbal fluency task (VFT). Functional near infrared spectroscopy (fNIRS) is emerging as an auxiliary diagnostic tool to evaluate brain function, providing an objective criterion to judge psychoses. At present, the conclusions derived from VFT or rest (non-task) studies are controversial. The purpose of this study is to evaluate if task performs better than non-task in separating healthy people from psychiatric patients. In this study, healthy controls (HCs) as well as the patients with MD or A&D were recruited (n = 10 for each group) to participate in the non-task and VFT tasks, respectively, and the brain oxygenation was longitudinally evaluated by using fNIRS. An approach of spectral analysis is used to analyze cerebral hemoglobin parameters (i.e., Oxy and Deoxy), characterizing the physiological fluctuations in the non-task and task states with magnitude spectrum and average power. Moreover, the standard deviation of oxygenation responses during the non-task was compared with the peak amplitude during the task, with the aim to explore the sensitivity of the VFT task to brain activation. The results show that there is no significant difference (p > 0.05) among the three groups in average power during non-task. The VFT task greatly enhanced the magnitude spectrum, leading to significant difference (p < 0.05) in average power between any of two groups (HC, MD, and A&D). Moreover, 40% patients with A&D have an intermediate peak (around 0.05 Hz) in the magnitude spectrum when performing the VFT task, indicating its advantage in characterizing A&D. We defined a rate of the non-task standard variation to the task peak amplitude (namely, SD-to-peak rate) and found that this rate is larger than 20% in 90% of the MD subjects. By contrast, only 40% HC subjects have an SD-to-peak rate larger than 20%. These results indicate that the non-task may not be sufficient to separate MD or A&D from HC. The VFT task could enhance the characteristics of the magnitude spectrum, but its intensity needs to be elevated so as to properly explore brain functions related to psychoses.

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“…Even though, the temporal dynamics of blood flows can be inferred from the speckle statistics of the captured frame. This method is termed speckle visibility spectroscopy (SVS), or speckle contrast spectroscopy [16][17][18][19][20] . In the SVS-based approach, a whole speckle pattern containing many speckle grains is captured using a detector array (e.g., a CCD camera), and the statistics of the blurred speckle pattern is used to calculate the speckle decorrelation time.…”

Section: Introductionmentioning

confidence: 99%

Interferometric speckle visibility spectroscopy (ISVS) for human cerebral blood flow monitoring

Xu¹,

Jahromi²,

Brake³

et al. 2020

Preprint

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Infrared light scattering methods have been developed and employed to non-invasively monitor human cerebral blood flow (CBF). However, the number of reflected photons that interact with the brain is low when detecting blood flow in deep tissue. To tackle this photon-starved problem, we present and demonstrate the idea of interferometric speckle visibility spectroscopy (ISVS). In ISVS, an interferometric detection scheme is used to boost the weak signal light. The blood flow dynamics are inferred from the speckle statistics of a single frame speckle pattern. We experimentally demonstrated the improvement of measurement fidelity by introducing interferometric detection when the signal photon number is insufficient.We apply the ISVS system to monitor the human CBF in situations where the light intensity is ∼100-fold less than that in common diffuse correlation spectroscopy (DCS) implementations. Due to the large number of pixels (∼ 2 × 10 5 ) used to capture light in the ISVS system, we are able to collect a similar number of photons within one exposure time as in normal DCS implementations. Our system operates at a sampling rate of 100 Hz. At the exposure time of 2 ms, the average signal photon electron number is ∼0.95 count/pixel, yielding a single pixel interferometric measurement signal-to-noise ratio (SNR) of ∼0.97. The total ∼ 2 × 10 5 pixels provide an expected overall SNR of 436. We successfully demonstrate that the ISVS system is able to monitor the human brain pulsatile blood flow, as well as the blood flow change when a human subject is doing a breath holding task.

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Noncontact Speckle Contrast Diffuse Correlation Tomography of Blood Flow Distributions in Burn Wounds: A Preliminary Study

Cited by 19 publications

References 18 publications

Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets

Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets

Task and Non-task Brain Activation Differences for Assessment of Depression and Anxiety by fNIRS

Interferometric speckle visibility spectroscopy (ISVS) for human cerebral blood flow monitoring

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