Noncontiguous finished genome sequence of Megasphaera sp. ASD88, isolated from faeces of a child with autism spectrum disorder

Chaplin, Andrei V.; Polyakova, S.; Kochetkova, Taisiya O.; Sokolova, Sofia Romanovna; Goltsov, Alexei A.; Trofimov, Trofimov D.Yu.; Ефимов, Б. А.

doi:10.1016/j.nmni.2017.12.010

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…The genus Megasphaera comprises butyrate-producing organisms within the Firmicutes phylum. Members of the Megasphaera genus have been isolated from a variety of anaerobic environments, including the intestinal tracts of pigs, cows, and humans ( 1 – 5 ). Here, we describe the complete genome sequence of a recently characterized Megasphaera species, isolated from the cecal contents of a healthy white leghorn chicken.…”

Section: Announcementmentioning

confidence: 99%

Complete Genome Sequence of Megasphaera stantonii AJH120 ^T , Isolated from a Chicken Cecum

Maki

Looft

2018

Microbiol Resour Announc

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Section: Announcementmentioning

confidence: 99%

Complete Genome Sequence of Megasphaera stantonii AJH120 ^T , Isolated from a Chicken Cecum

Maki

Looft

2018

Microbiol Resour Announc

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“…According to the most recent epidemiological study, the global prevalence of ASD is 0.62% [2]. Autism is a chronic, life-long condition that cannot be reversed [3]. The etiological basis of ASD is still unknown.…”

Section: Introductionmentioning

confidence: 99%

In Silico Identification of Novel HDAC2 Inhibitors for Reinstating Synaptic wiring in Autism Spectrum Disorder

Alharbi

2024

Adv. life sci.

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Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an increasing incidence rate. For the treatment of ASD, several pharmaceutical approaches, dietary supplements, and behavioral therapy have been proposed, but a definitive cure remains elusive. Histone deacetylases (HDACs) are critical epigenetic regulators whose molecular and pharmacological roles are being studied extensively in medically significant ailments such as neuropsychiatric disorders, neurodegenerative diseases, and cancer on a global scale. HDAC2's specific expression pattern in CNS makes it an appealing therapeutic target for neurological illnesses such as ASD.Methods: The study used PyRx software (version 0.8) to screen a library of 401 alkaloid compounds against HDAC2. In addition, the DS software was used to predict the physicochemical and DMET properties of the compound library.Results: Valaciclovir hydrochloride, Dihydrocapsaicin, Guanosine, Santacruzamate A, and 2'-Deoxyguanosine monohydrate compounds exhibited strong interactions with HDAC2. These compounds had a higher binding energy than the control compound, and they have promising drug-like properties and ADMET characteristics.Conclusion: These identified compounds could be used as HDAC2 inhibitors for the management of ASD, however, experimental research is needed to optimize them as HDAC2 inhibitors.Keywords: Autism spectrum disorder; Histone deacetylases; Alkaloid compounds; Drug-likeness

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“…e most recent study estimates the global prevalence of ASD to be 0.62% [2]. ASD is a chronic, lifelong disease that cannot be reversed [3]. e etiology of ASD has yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

A Multi-Target and Multi-Channel Mechanism of Action for Jiawei Yinhuo Tang in the Treatment of Social Communication Disorders in Autism: Network Pharmacology and Molecular Docking Studies

Zhang

Ciai

Yanhong

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder with complex pathogenesis. Currently, the pathogenesis of ASD is not fully understood. Moreover, current treatments do not effectively alleviate the primary symptoms of ASD social disorder (SCDA). Jiawei Yinhuo Tang (JWYHT) is an improved version of the classic prescription Yinhuo Tang. Although this medication has been shown to improve social behavior in ASD patients, the mechanism by which it works remains unknown. Methods. In this study, network pharmacology bioinformatics analysis was used to identify the key targets, biological functions, and signal pathways of JWYHT in SCDA. Then, molecular docking and molecular dynamic simulation were used to validate the activity and stability of the active ingredient and the target protein during the binding process. Results. The analysis identified 157 key targets and 9 core targets of JWYHT (including proto-oncogene (FOS), caspase 3 (CASP3), mitogen-activated protein kinase-3 (MAPK3), interleukin-6 (IL6), mitogen-activated protein kinase-1 (MAPK1), tumor necrosis factor (TNF), mitogen-activated protein kinase-8 (MAPK8), AKT serine/threonine kinase 1 (AKT1), and 5-hydroxytryptamine receptor 1B (5HT1B)) in SCDA. In addition, the Kyoto Encyclopedia of Gene and Genome results, as well as the staggering network analyses, revealed 20 biological processes and 20 signal pathways targeted by JWYHT in SCDA. Finally, molecular docking analysis was used to determine the binding activity of the main active components of JWYHT to the key targets. The binding activity and stability of methyl arachidonate and MAPK8 were demonstrated using molecular dynamics simulation. Conclusion. This study demonstrates that JWYHT regulates neuronal development, synaptic transmission, intestinal and cerebral inflammatory response, and other processes in SCDA.

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Noncontiguous finished genome sequence of Megasphaera sp. ASD88, isolated from faeces of a child with autism spectrum disorder

Cited by 7 publications

References 13 publications

Complete Genome Sequence of Megasphaera stantonii AJH120 ^T , Isolated from a Chicken Cecum

Complete Genome Sequence of Megasphaera stantonii AJH120 ^T , Isolated from a Chicken Cecum

In Silico Identification of Novel HDAC2 Inhibitors for Reinstating Synaptic wiring in Autism Spectrum Disorder

A Multi-Target and Multi-Channel Mechanism of Action for Jiawei Yinhuo Tang in the Treatment of Social Communication Disorders in Autism: Network Pharmacology and Molecular Docking Studies

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Noncontiguous finished genome sequence of Megasphaera sp. ASD88, isolated from faeces of a child with autism spectrum disorder

Cited by 7 publications

References 13 publications

Complete Genome Sequence of Megasphaera stantonii AJH120 T , Isolated from a Chicken Cecum

Complete Genome Sequence of Megasphaera stantonii AJH120 T , Isolated from a Chicken Cecum

In Silico Identification of Novel HDAC2 Inhibitors for Reinstating Synaptic wiring in Autism Spectrum Disorder

A Multi-Target and Multi-Channel Mechanism of Action for Jiawei Yinhuo Tang in the Treatment of Social Communication Disorders in Autism: Network Pharmacology and Molecular Docking Studies

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Complete Genome Sequence of Megasphaera stantonii AJH120 ^T , Isolated from a Chicken Cecum

Complete Genome Sequence of Megasphaera stantonii AJH120 ^T , Isolated from a Chicken Cecum