Noncontrast Perfusion Single-Photon Emission CT/CT Scanning

Lü, Yang; Lorenzoni, Alice; Fox, Josef J.; Rademaker, Jürgen; Vander, Nicholas; Grewal, Ravinder K.; Strauss, H. William; Schöder, Heiko

doi:10.1378/chest.13-2090

Cited by 49 publications

(69 citation statements)

References 31 publications

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“…These data confirm previous results indicating that the PISA-PED criteria perform better than the modified PIOPED criteria for the interpretation of planar perfusion imaging. There was no substantial increase in the accuracy for perfusion SPECT/CT compared with planar imaging when the PISA-PED criteria were used for interpretation of the planar perfusion scans [43].…”

Section: Perfusion Spect/ctmentioning

confidence: 91%

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Critical review of SPECT imaging in pulmonary embolism

Stein

Sostman

Matta

2014

Clin Transl Imaging

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Outcome studies have shown that pulmonary embolism can be safely excluded in patients with negative ventilation/perfusion (V/Q) single-photon emission computed tomography (SPECT). The effective radiation dose of V/Q SPECT is much less than with computed tomographic (CT) pulmonary angiography, which would make it preferable to CT angiography in many young female patients. The accuracy of V/Q SPECT, however, is difficult to assess, because most published investigations are limited by incorporation bias or partial verification bias, as well as other limitations in study design and reporting. Consequently, the accuracy of V/Q SPECT relative to planar V/Q scintigraphy or CT angiography has not been definitively determined. There is need for a prospective investigation of the accuracy of V/Q SPECT with consecutive patients, blinded interpretations, and an independent reference standard, or independent composite reference standard.Keywords Pulmonary embolism Á Venous thromboembolism Á Single-photon emission computed tomography Since the publication of the prospective investigation of pulmonary embolism diagnosis (PIOPED) in 1990 [1], there has been a decline in the use of ventilation/perfusion (V/Q) planar scintigraphy [2] and widespread adoption of computed tomographic (CT) pulmonary angiography for the diagnosis of acute pulmonary embolism (PE) [2]. The development of tomographic radionuclide imaging presents diagnostic possibilities that were not available at the time of publication of the PIOPED. In 2009, together with colleagues, we reviewed the use of single-photon emission computed tomography (SPECT) in acute PE [3]. Numerous observations with SPECT in the 5 years since then prompted us to conduct the present review of its potential role in evaluating patients with PE. One aim of this review is to present data that will allow physicians to make informed choices regarding the use of SPECT in patients with suspected PE.We searched PubMed using the following search terms: SPECT PE matched with accuracy (20 results), sensitivity (34 results), specificity (39 results); SPECT pulmonary embolism matched with accuracy (35 results), sensitivity (78 results), specificity (80 results); single-photon emission computed tomography pulmonary embolism matched with accuracy (30 results), sensitivity (71 results), specificity (72 results); single-photon emission computed tomography pulmonary embolism (174 results); SPECT pulmonary embolism (197 results). We also checked the references of relevant studies to identify additional investigations. The inclusion criteria were: studies in all languages related to the accuracy of SPECT that included [10 patients suspected of having acute PE and showed or allowed the reader to calculate sensitivity, specificity, and results of clinical follow-up. We identified 21 such articles and 2 preliminary articles with fewer patients that were of interest. Some addressed more than one topic.

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Section: Perfusion Spect/ctmentioning

confidence: 91%

“…Perfusion SPECT/CT compared with planar V/Q scintigraphy Perfusion SPECT/CT was found to be more sensitive than planar V/Q scans in 106 patients with cancer and a high risk of PE [43]. The diagnosis of PE was based on clinical findings, lower extremity Doppler studies, CT angiography when available, and follow-up.…”

Section: Perfusion Spect/ctmentioning

confidence: 99%

Critical review of SPECT imaging in pulmonary embolism

Stein

Sostman

Matta

2014

Clin Transl Imaging

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“…Main cause of challenges consists in similarity of clinical presentation of CAP and other diseases manifesting with development of infiltrative processes in the lungs (malignant neoplasms, infiltrative pulmonary tuberculosis, pulmonary embolism, etc.) [3][4][5][6]. The process for developing a differential diagnosis between CAP and peripheral lung cancer is associated with particular difficulties [3].…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, 60% to 90% of initial patients with lung cancer undergo wrongful treatment for pneumonia, tuberculosis, and some other diseases [4,6]. The causes of late diagnosis of lung cancer generally comprise symptom non-specificity resulting in high likelihood of false negative results of chest X-ray examination [4].…”

Section: Introductionmentioning

confidence: 99%

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Lung scintigraphy in differential diagnosis of peripheral lung cancer and community-acquired pneumonia

Кривоногов¹,

Efimova²,

Zavadovsky³

et al. 2016

AIP Conference Proceedings

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Abstract. Ventilation/perfusion lung scintigraphy was performed in 39 patients with verified diagnosis of communityacquired pneumonia (CAP) and in 14 patients with peripheral lung cancer. Ventilation/perfusion ratio, apical-basal gradients of ventilation (U/L(V)) and lung perfusion (U/L(P)), and alveolar capillary permeability of radionuclide aerosol were determined based on scintigraphy data. The study demonstrated that main signs of CAP were increases in ventilation/perfusion ratio, perfusion and ventilation gradient on a side of the diseased lung, and two-side increase in alveolar capillary permeability rate for radionuclide aerosol. Unlike this, scintigraphic signs of peripheral lung cancer comprise an increase in ventilation/perfusion ratio over 1.0 on a side of the diseased lung with its simultaneous decrease on a contralateral side, normal values of perfusion and ventilation gradients of both lungs, and delayed alveolar capillary clearance in the diseased lung compared with the intact lung.

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Diseases of the Pulmonary System

Bozkurt¹,

Volkan‐Salanci²

2023

Radiology‐Nuclear Medicine Diagnostic Imaging

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Noncontrast Perfusion Single-Photon Emission CT/CT Scanning

Cited by 49 publications

References 31 publications

Critical review of SPECT imaging in pulmonary embolism

Critical review of SPECT imaging in pulmonary embolism

Lung scintigraphy in differential diagnosis of peripheral lung cancer and community-acquired pneumonia

Diseases of the Pulmonary System

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