Noncovalent force spectroscopy using wide-field optical and diamond-based magnetic imaging

Lourette, Sean; Bougas, Lykourgos; Kayci, Metin; Xu, Shoujun; Budker, Dmitry

doi:10.1063/1.5125273

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…Our results may be immediately relevant to applications in precision navigation, geoscience, and medical imaging. More broadly, the use of micro-structured magnetic materials to manipulate magnetic fields offers a new degree of freedom for the design of diamond quantum sensors, with potential applications in magnetic microscopy [6][7][8][9][10][11][12][13] and tests of fundamental physics [50].…”

Section: Discussionmentioning

confidence: 99%

“…At the few-nanometer scale, single NV centers have been used to detect magnetic phenomena in condensed-matter [ 2 , 3 ] and biological [ 4 , 5 ] samples. At the scale of a few hundred nanometers, diamond magnetic microscopes have been used to image biomagnetism in various systems, including magnetically labeled biomolecules [ 6 ] and cells [ 7 , 8 ] and intrinsically magnetic biocrystals [ 9 , 10 ]. At the micrometer scale, diamond magnetometers have detected the magnetic fields produced by neurons [ 11 ], integrated circuits [ 12 , 13 ], and the nuclear magnetic resonance of fluids [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Diamond magnetometer enhanced by ferrite flux concentrators

Fescenko

Jarmola

Savukov

et al. 2020

Phys. Rev. Research

127

109

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Magnetometers based on nitrogen-vacancy (NV) centers in diamond are promising room-temperature, solidstate sensors. However, their reported sensitivity to magnetic fields at low frequencies (1 kHz) is presently 10 pT s 1/2 , precluding potential applications in medical imaging, geoscience, and navigation. Here we show that high-permeability magnetic flux concentrators, which collect magnetic flux from a larger area and concentrate it into the diamond sensor, can be used to improve the sensitivity of diamond magnetometers. By inserting an NV-doped diamond membrane between two ferrite cones in a bowtie configuration, we realize a ∼250-fold increase of the magnetic field amplitude within the diamond. We demonstrate a sensitivity of ∼0.9 pT s 1/2 to magnetic fields in the frequency range between 10 and 1000 Hz. This is accomplished using a dual-resonance modulation technique to suppress the effect of thermal shifts of the NV spin levels. The magnetometer uses 200 mW of laser power and 20 mW of microwave power. This work introduces a new degree of freedom for the design of diamond sensors by using structured magnetic materials to manipulate magnetic fields.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diamond magnetometer enhanced by ferrite flux concentrators

Fescenko

Jarmola

Savukov

et al. 2020

Phys. Rev. Research

127

109

View full text Add to dashboard Cite

show abstract

“…The NV-diamond magnetometers were also used to investigate the magnetic state, structure, and orientation of the iron biominerals with quantitative mapping of static (ODMR) and fluctuating (quantum relaxation microscopy [QRM]) magnetic fields (Figure 7A). [139] In addition, for artificially manufactured bioprobes like MNPs, which have been widely employed for magnetic imaging, [41,140] magnetogenetics, [60] and vitro diagnostics, [16,42,141,142] localized detection of magnetic fields is critical. Measurements of the magnetic field produced by the neurons, such as synaptic transmission [143,144] and muscular contraction, [137] are essential for clinical diagnosis and a basic understanding of physiology (Alzheimer's disease and other forms of dementia).…”

Section: Nv-diamond Magnetometers For Biomagnetic Signal Detections W...mentioning

confidence: 99%

Quantum‐Based Magnetic Field Sensors for Biosensing

Bao

Wang

et al. 2023

Adv Quantum Tech

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The accurate detection of very weak biomagnetic signals with a sensitivity of fT levels and mapping nanoscale magnetic field variations are two of the most significant challenges for biosensing. Compared to the limited sensitivity and spatial resolution of traditional magnetic field sensors, quantum‐based magnetic field sensors are emerging as a promising solution. In this review, the latest developments of three representative quantum‐based magnetic field sensors, including superconducting quantum interference device (SQUID) magnetometers, spin exchange relaxation free (SERF) atomic magnetometers, and nitrogen‐vacancy centers in diamond, are summarized. Both virtues and limitations of these sensors are analyzed systematically, and typical applications in magnetocardiography, magnetoencephalography, detection of neuronal action potentials, magnetic imaging of living cells, biomedical diagnosis, etc., are presented. Furthermore, SQUIDs combined with microfluidics for magnetic immunoassay diagnostics, the chip‐scale SERF atomic magnetometers fabricated by microelectromechanical systems that offer wearable flexibility, and nanodiamonds functionalized with magnetic nanoparticles to improve the sensitivity of nanothermometers are discussed.

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“…In the first category are sensors that detect multiple complementary physical signatures of the investigated object or phenomenon. Examples include the combination of wide-field optical microscopy and NV magnetometry [100,101] used to realize NV-based force-induced remnant magnetization spectroscopy (NV-FIRMS) for measuring the magnitude of binding forces between biologically relevant molecules, as well as wide-field NV magnetometry combined in a single setup with a magnetooptical Kerr-effect (MOKE) microscope [102]. The idea of the latter is that MOKE is sensitive to surface magnetization which does not necessarily produce a magnetic field outside of the sample, so combining it with NV magnetometry that measures the field provides a more complete diagnostic picture.…”

Section: E Hybrid Modalitiesmentioning

confidence: 99%

Sensitive magnetometry in challenging environments

Fu¹,

Iwata²,

Wickenbrock³

et al. 2020

Preprint

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State-of-the-art magnetic field measurements performed in shielded environments with carefully controlled conditions rarely reflect the realities of those applications envisioned in the introductions of peer-reviewed publications. Nevertheless, significant advances in magnetometer sensitivity have been accompanied by serious attempts to bring these magnetometers into the challenging working environments in which they are often required. In this review, we cover the ways in which various magnetometer technologies have been adapted for use in challenging environments.

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Noncovalent force spectroscopy using wide-field optical and diamond-based magnetic imaging

Cited by 4 publications

References 23 publications

Diamond magnetometer enhanced by ferrite flux concentrators

Diamond magnetometer enhanced by ferrite flux concentrators

Quantum‐Based Magnetic Field Sensors for Biosensing

Sensitive magnetometry in challenging environments

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