Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

Hosta‐Rigau, Leticia; Chandrawati, Rona; Saveriades, E.; Odermatt, Pascal D.; Postma, Almar; Ercole, Francesca; Breheney, Kerry; Wark, Kim L.; Städler, Brigitte; Caruso, Frank

doi:10.1021/bm101020e

Cited by 64 publications

(60 citation statements)

References 49 publications

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“…Thiocoraline (TC) loaded liposomes ( TC L) were assembled by adding 100 lL (0.1 mg/mL) TC in chloroform to the lipid mixture prior to drying. This TC concentration was chosen to ensure the highest amount of incorporated cargo into the lipid membrane of the liposomes based on our previous reports [29,30]. Thus, increasing TC concentration above 0.1 mg/mL does not results in an increase in the amount of liposome-loaded TC.…”

Section: Synthesis Of Oleoyldopaminementioning

confidence: 99%

Myoblast Cell Interaction with Polydopamine Coated Liposomes

et al. 2012

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Liposomes are widely used, from biosensing to drug delivery. Their coating with polymers for stability and functionalization purposes further broadens their set of relevant properties. Poly(dopamine) (PDA), a eumelanin-like material deposited via the “self”-oxidative polymerization of dopamine at mildly basic pH, has attracted considerable interest in the past few years due to its simplicity, flexibility yet fascinating properties. Herein, we characterize the coating of different types of liposomes with PDA depending on the presence of oleoyldopamine in the lipid bilayer and the dopamine hydrochloride concentration. Further, the interaction of these coated liposomes in comparison to their uncoated counterparts with myoblast cells is assessed. Their uptake/association efficiency with these cells is determined. Further, their dose-dependent cytotoxicity with and without entrapped hydrophobic cargo (thiocoraline) is characterized. Taken together, the reported results demonstrate the potential of PDA coated liposomes as a tool in biomedical applications. Supplementary Material 13758_2011_8_MOESM1_ESM.doc (83KB)

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Section: Synthesis Of Oleoyldopaminementioning

confidence: 99%

Myoblast Cell Interaction with Polydopamine Coated Liposomes

et al. 2012

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“…DMAm [348] DMAm-b-HEAm [348] 97 n ϭ 1 or 2 [349,350] DEAEMA [351] DMAEMA [350,352] PEGMA [224,[353][354][355] (412) [243] PAA [356] DMAm [326] DMAm [326] HPMAm [357] 357 [357] MAA/PEGMA [354] APMAm/DEAPMAm [358] APMAm/DMAPMAm [358] DEAEMA-bNIPAm [351] DMEAEMA-b-NIPAm [359] PEGMA/MAA-b-St [354,360] PEGMA/MAA-bBzMA [361] PEGMA/MAA-b-327 [362] PAA-bDMAm/408 [356] DMAEMA-b-(PAA/BMA/ DMAEMA) [350,352] HPMAm/450/451 [363] HPMAm-b-357 [357] 98 [364] 317 [311] 332 [365] 333 [365] DMAm [366] BA [366] 350 [311] NIPAm [366,367] MAA/ MMA [368] MAA/DFHA [369] OeMA/MMA [364] 332-b-MMA [365] 333-b-MMA [365] NIPAm-bDMAEAm [367] 99…”

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confidence: 99%

Living Radical Polymerization by the RAFT Process – A Third Update

2012

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This paper provides a third update to the review of reversible deactivation radical polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC(¼S)SR) by a mechanism of reversible addition-fragmentation chain transfer ( Chem. 2009Chem. , 62, 1402. This review cites over 700 publications that appeared during the period mid 2009 to early 2012 covering various aspects of RAFT polymerization which include reagent synthesis and properties, kinetics and mechanism of polymerization, novel polymer syntheses, and a diverse range of applications. This period has witnessed further significant developments, particularly in the areas of novel RAFT agents, techniques for end-group transformation, the production of micro/nanoparticles and modified surfaces, and biopolymer conjugates both for therapeutic and diagnostic applications.

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“…Further, we have demonstrated the functionality of capsosomes by performing two different triggered enzymatic assays14, 17 and a two‐step enzymatic catalytic reaction 18. The absence of inherent cytotoxicity of capsosomes (by performing a cell viability assay)19 makes capsosomes promising candidates for biomedical applications.…”

Section: Introductionmentioning

confidence: 94%

Advanced Subcompartmentalized Microreactors: Polymer Hydrogel Carriers Encapsulating Polymer Capsules and Liposomes

Hosta‐Rigau

Shimoni

Städler

et al. 2013

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The design of compartmentalized carriers for advanced drug delivery systems or artificial cells and organelles is of interest for biomedical applications. Herein, a polymer carrier microreactor that contains two different classes of subcompartments, multilayered polymer capsules and liposomes, is presented. 50 nm-diameter liposomes and 300 nm-diameter polymer capsules are encapsulated into a larger polymer carrier capsule, demonstrating control over the spatial positioning of the subcompartments, which are either 'membrane-associated' or 'free-floating' in the aqueous interior. Selective and spatially dependent degradation of the 300 nm-diameter subcompartments (without destroying the structural integrity of the enzyme-loaded liposomes) is also shown, by performing an encapsulated enzymatic reaction using the liposomal subcompartments. These findings cover several important aspects toward the development of engineered compartmentalized carrier vessels for the creation of artificial cell mimics or advanced therapeutic delivery systems.

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Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

Cited by 64 publications

References 49 publications

Myoblast Cell Interaction with Polydopamine Coated Liposomes

Myoblast Cell Interaction with Polydopamine Coated Liposomes

Living Radical Polymerization by the RAFT Process – A Third Update

Advanced Subcompartmentalized Microreactors: Polymer Hydrogel Carriers Encapsulating Polymer Capsules and Liposomes

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