Nondaily Statin Dosing: Mechanisms of a Potentially Important Approach to Dealing With Statin Intolerance

Statin intolerance: more questions than answers

“…The strategy of dose reduction takes advantage of the fact that LDL-lowering responds to the logarithm of statin dose, while adverse effects appear to be more or less proportionate to dose. Nondaily statin dosing and tablet splitting are strategies that often decrease LDL-C more than full doses of nonstatin drugs [16,17]. We commonly try 5 mg atorvastatin taken 2 or 3 days a week and decide if it is sufficient based on the individual patient's LDL-C result.…”