Nonenzymatic Electrochemical Biosensor Based on Novel Hydrophilic Ferrocene‐terminated Hyperbranched Polymer and its Application in Glucose Detection

Abstract

We designed a novel water soluble topological structure polymer‐ferrocene‐ terminated hyperbranched polyurethane (HPU‐Fc) with good water solubility. The redox behaviors and the electrochemical kinetics parameters of HPU‐Fcs were explored by cyclic voltammetry (CV) according to electrochemical principle. The topological structure polymer was applied for the design and engineering of non‐enzymatic glucose sensor. The designed sensor showed good response to glucose concentration with good stability, favorable accuracy and high selectivity. The electrode was also used to detect glucose in blood samples, and the glucose contents detected by the electrode were in good agreement with those from the hospital where a common automatic biochemical analyzer (HF240–300) was used. This finding makes HPU‐Fc a promising biosensor for directly sensing glucose.

Evaluating the Feasibility of Microbial Electrosynthesis Based on Gluconobacter oxydans

“…This is especially critical, when considering the study of Li et al. showing an abiotic sensor for glucose being only based on platinum modified with polymer‐functionalized ferrocene …”

Electrospun nanofibers fromferrocene‐containingmultiblock copolymers prepared viaRAFTpolymerization withF127modified precursor

“…Ferrocene and ferrocene derivatives have been focused on attributed to their unique applications such as electrochemistry, 10 biosensors, 10–11 molecular recognition, 11–12 catalysis, 13–14 fertilizers, 15 magnetism, 16 cancer treatment 17 and others 18–19 . Especially, ferrocene‐bearing polymers were of interest in the excellent combination of redox, mechanical, semi‐conductive, photo‐physical, and opto‐electronic properties 11,20–21 .…”

A Non-Enzymatic Sensor Based on Fc-CHIT/CNT@Cu Nanohybrids for Electrochemical Detection of Glucose

“…Using portable electronic devices to directly detect glucose is a convenient diagnostic method in the initial steps. A literature survey found that glucose sensors can be divided into two categories: enzyme-based sensors [ 5 , 6 ] and enzyme-free sensors [ 7 , 8 ]. Enzyme-based electrochemical biosensors are complex, expensive and affected by temperature and pH due to enzyme activity.…”