Nonenzymatic Glucose Detection Using Mesoporous Platinum

Abstract

Roughness of nanoscopic dimensions can be used to selectively enhance the faradaic current of a sluggish reaction. Using this principle, we constructed mesoporous structures on the surfaces of pure platinum electrodes responding even more sensitively to glucose than to common interfering species, such as L-ascorbic acid and 4-acetamidophenol. Good sensitivities, as high as 9.6 microA cm(-2) mM(-1), were reproducibly observed in the presence of high concentration of chloride ion. The selectivities, sensitivities, and stabilities determined experimentally have demonstrated the potential of mesoporous platinum as a novel candidate for nonenzymatic glucose sensors.

Fabrication of biosensors using vinyl polymer-grafted carbon nanotubes

“…Initial research developing non-enzymatic sensors focused on the use of nanocrystalline metals, such as Pt and Au, especially Pt-based amperometric electrodes (S. J. Park et al, 2003;Song et al, 2005). However, such Pt-based glucose sensors lacked sufficient selectivity and sensitivity due to chemisorbed intermediates and electroactive species.…”

Integration of a Nanoporous Platinum Thin Film into a Microfluidic System for Non-enzymatic Electrochemical Glucose Sensing

“…20 Silver (Ag) was electroplated on the Pt film of reference electrode areas using a commercial Ag electroplating agent (Hanyang Chemical, Korea). One micrometer thick Ag film was formed by applying a constant potential (-1.0 V vs. Ag/AgCl) using a potentiostat (CHI750A, CH Instrument, Austin, TX).…”

“…19 Nanoporous platinum thin films are excellent glucose detectors, and substantially overcome the critical shortcomings of other enzymeless sensors. 20 Moreover, glucose Integration of a Nanoporous Platinum Thin Film into a Microfluidic System for Non-enzymatic Electrochemical Glucose Sensing sensors based on nanoporous Pt technology are compatible with conventional microfabrication post-processing, since the electrode is composed of Pt. In addition, unlike pulsed amperometric detection, 21,22 nanoporous Pt does not require a sample separation step, because its selectivity prevents REDOX interference by species like ascorbic acid or acetaminophenol.…”

Functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose

“…When glucose levels in the bloodstream are not properly regulated, diseases such as diabetes can develop. Because of the high demand for blood-glucose monitoring, significant research has been devoted to producing reliable methods for in vitro or in vivo glucose measurement, such as fluorescence spectroscopy (Ballerstadt and Schultz, 2000), diffraction spectroscopy (Asher et al, 2003), surface-enhanced Raman scattering (Shafer et al, 2003), a wireless magnetoelastic sensor (Cai et al, 2004), an electrochemical transistor sensor (Forzani et al, 2004;Raffa et al, 2003), an enzyme-based amperometric sensor (Zen et al, 2003;Hrapovic et al, 2004;Lin et al, 2004;Yang et al, 2004;Zhou et al, 2005), a nanoenzymetric amperometric sensor (Park et al, 2003), nuclear magnetic resonance spectroscopy (Cline et al, 1998) and a potentiometric sensor (Shoji et al, 2001). Since the development of the first glucose biosensor, improvement of the response performance of enzyme electrodes has been the main focus of biosensor research (Raitman et al, 2002).…”