Nonenzymatic glucose detection using multi-walled carbon nanotube electrodes

Ye, Jianshan; Wen, Ying; Zhang, Wei De; Gan, L. M.; Xu, Guo Qin; Sheu, Fwu‐Shan

doi:10.1016/j.elecom.2003.10.013

Cited by 313 publications

(101 citation statements)

References 37 publications

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“…Though the exact mechanism for the electrocatalytic behavior of MWCNTs has not yet been deciphered, it is believed that a combination of defect sites at the cap and the presence of oxygen-containing functional groups contribute to the electrocatalytic effect of MWCNTs (Hu and Hu 2009). The alkaline medium has been reported to activate the surface functionalities in MWCNTs (Ye et al 2004). Moreover, the surface roughness also contributes in enhancing the sensitivity of the CNT-modified surface towards the analyte.…”

Section: Electrochemical Measurementsmentioning

confidence: 99%

“…Only few reports are available on the electrocatalytic nature of pristine CNTs towards sensing applications. These sensors were investigated in simulated samples and no real-time analysis was performed in the earlier studies (Ye et al 2004). In the present study, a mildly alkaline electrolyte is employed instead of the highly alkaline systems reported earlier to ensure that there are no adverse effects on the biological sample being investigated.…”

Section: Introductionmentioning

confidence: 99%

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Enzyme-free monitoring of glucose utilization in stimulated macrophages using carbon nanotube-decorated electrochemical sensor

et al. 2017

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Carbon nanotubes (CNTs) have been extensively explored for a diverse range of applications due to their unique electrical and mechanical properties. CNT-incorporated electrochemical sensors have exhibited enhanced sensitivity towards the analyte molecule due to the excellent electron transfer properties of CNTs. In addition, CNTs possess a large surface area-to-volume ratio that favours the adhesion of analyte molecules as well as enhances the electroactive area. Most of the electrochemical sensors have employed CNTs as a nano-interface to promote electron transfer and as an immobilization matrix for enzymes. The present work explores the potential of CNTs to serve as a catalytic interface for the enzymeless quantification of glucose. The figure of merits for the enzymeless sensor was comparable to the performance of several enzyme-based sensors reported in literature. The developed sensor was successfully employed to determine the glucose utilization of unstimulated and stimulated macrophages. The significant difference in the glucose utilization levels in activated macrophages and quiescent cells observed in the present investigation opens up the possibilities of new avenues for effective medical diagnosis of inflammatory disorders.

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Section: Electrochemical Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enzyme-free monitoring of glucose utilization in stimulated macrophages using carbon nanotube-decorated electrochemical sensor

et al. 2017

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“…Under normal physiological conditions, glucose concentration fluctuates within 110 ± 25 mg dL −1 (around 6 μM), whereas diabetics may reach 360 mg dL −1 (20 μM) or higher. 171 Biosensors functioning for these ranges are important to control glucose concentration in the blood of patients, both in hospitals as well as in their homes. The first widely commercialized biosensor was for glucose detection.…”

Section: Graphenementioning

confidence: 99%

Nanomaterials for Diagnosis: Challenges and Applications in Smart Devices Based on Molecular Recognition

Oliveira

Iost

Siqueira

et al. 2014

ACS Appl. Mater. Interfaces

156

137

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Clinical diagnosis has always been dependent on the efficient immobilization of biomolecules in solid matrices with preserved activity, but significant developments have taken place in recent years with the increasing control of molecular architecture in organized films. Of particular importance is the synergy achieved with distinct materials such as nanoparticles, antibodies, enzymes, and other nanostructures, forming structures organized on the nanoscale. In this review, emphasis will be placed on nanomaterials for biosensing based on molecular recognition, where the recognition element may be an enzyme, DNA, RNA, catalytic antibody, aptamer, and labeled biomolecule. All of these elements may be assembled in nanostructured films, whose layer-by-layer nature is essential for combining different properties in the same device. Sensing can be done with a number of optical, electrical, and electrochemical methods, which may also rely on nanostructures for enhanced performance, as is the case of reporting nanoparticles in bioelectronics devices. The successful design of such devices requires investigation of interface properties of functionalized surfaces, for which a variety of experimental and theoretical methods have been used. Because diagnosis involves the acquisition of large amounts of data, statistical and computational methods are now in widespread use, and one may envisage an integrated expert system where information from different sources may be mined to generate the diagnostics.

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“…Specifically, Davis et al [84] and Besteman et al [85] employed single-walled CNTs (SWCNT) whilst Ye et al [86] adopted multi-walled CNTs (MWCNT) for the detection of glucose. Apart from glucose, another oxidase detection using CNTs is lactate oxidase [87].…”

Section: Electrical Current Measurementmentioning

confidence: 99%

A Conceptual Review of Nanosensors

Lim

Ramakrishna

2006

Zeitschrift Für Naturforschung A

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Nanosensors are gaining increasing attention due to the need to detect and measure chemical and physical properties in difficult to reach biological and industrial systems that are in the nano-scale region. This conceptual review surveys various nanosensors, which are categorized into three broad types: optical, electromagnetic and mechanical nanosensors. The sensing concepts and their corresponding advantages are discussed with reference to their applications.

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Nonenzymatic glucose detection using multi-walled carbon nanotube electrodes

Cited by 313 publications

References 37 publications

Enzyme-free monitoring of glucose utilization in stimulated macrophages using carbon nanotube-decorated electrochemical sensor

Enzyme-free monitoring of glucose utilization in stimulated macrophages using carbon nanotube-decorated electrochemical sensor

Nanomaterials for Diagnosis: Challenges and Applications in Smart Devices Based on Molecular Recognition

A Conceptual Review of Nanosensors

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