Nonepileptic Myoclonus Following Bupropion Overdose

Xiang, Xinran; Phillips, Donald J.

doi:10.1177/0009922817737082

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Two cases of the overdosed individuals needed gastric lavage and/or activated charcoal administration to reduce the absorption of the massive, ingested dose. 14,15 At least 1 anti-epileptic drug was prescribed to control abnormal movements in 7 cases. Clonazepam, lorazepam, and levetiracetam were the antiepileptic drugs that were most used.…”

Section: Discussionmentioning

confidence: 99%

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Bupropion-Induced Myoclonus: Case Report and Review of the Literature

Riaz¹,

Ali

Allahham

et al. 2023

The Neurohospitalist

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Bupropion is an atypical antidepressant agent approved for treating major depressive disorders and prescribed for smoking cessation, attention deficit hyperactive disorder (ADHD), and sexual dysfunction. In a few cases, bupropion was associated with myoclonus. We present a case of a 58-year-old male, a heavy smoker seeking smoking cessation, was prescribed bupropion 150 mg twice daily. The subject doubled the dosage without medical advice. After 3 days of the increased dosage, he started to experience abnormal movements in his upper limbs associated with diffuse facial twitching. Neuroimaging, electrodiagnostic studies, and laboratory exams were unremarkable. Bupropion was discontinued, and clonazepam was initiated. The subject fully recovered within 24 hours. To the authors’ knowledge, only 8 cases of bupropion-induced myoclonus were reported in the literature. Bupropion discontinuation was the most common management. All individuals except 2 cases fully recovered after bupropion withdrawal. The mechanism of bupropion is probably associated with the serotoninergic pathway.

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Section: Discussionmentioning

confidence: 99%

“…In 3 of them, the symptoms developed within 1 to 2 hours. [12][13][14][15] Discontinuation of bupropion was the basic management in all cases. Two cases of the overdosed individuals needed gastric lavage and/or activated charcoal administration to reduce the absorption of the massive, ingested dose.…”

Section: Discussionmentioning

confidence: 99%

Bupropion-Induced Myoclonus: Case Report and Review of the Literature

Riaz¹,

Ali

Allahham

et al. 2023

The Neurohospitalist

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show abstract

“…Additionally, tremors, lethargy, agitation, dry mouth, hallucinations, nausea and vomiting, confusion, dizziness, tachycardia, and conduction delays have also been reported [1,4]. Non-epileptic myoclonus was also mentioned as a side effect in one case report [7].…”

Section: Introductionmentioning

confidence: 93%

Single-Agent Bupropion Exposures: Clinical Characteristics and an Atypical Cause of Serotonin Toxicity

et al. 2019

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Introduction Bupropion is the only Food and Drug Administration-approved synthetic cathinone. It increases the release of norepinephrine in the locus coeruleus and dorsal raphe nucleus, causing an increase in the frequency of serotonergic neuron firing. The diagnosis of serotonin toxicity (ST) from bupropion poisoning is controversial due to the lack of direct serotonergic activity. Nonetheless, there is one documented report of ST after single-agent bupropion overdose and multiple reports describing polypharmacy overdoses where bupropion may have contributed to ST. Methods This is a retrospective analysis of data collected by the Toxicology Investigators Consortium (ToxIC), a prospective multi-center toxico-surveillance and research network registry, from 2014 to 2017. Cases were identified if ST was a clinical effect and bupropion was the single agent listed. Data is presented descriptively. Results Of the 266 recorded single bupropion overdoses, the most common symptoms were seizures (47.1%), tachycardia (greater than 140 bpm) (33.9%), agitation (31.7%), toxic psychosis (20.4%), and myoclonus/tremor/hyperreflexia (19%). Benzodiazepines were the most common therapy (69.2%). Thirteen patients (5.9%) were diagnosed with ST by a medical toxicologist. Conclusion Bupropion overdose is primarily associated with seizures, tachycardia, and agitation; bupropion may be an atypical cause of serotonin toxicity.

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Bupropion overdose

2018

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Nonepileptic Myoclonus Following Bupropion Overdose

Cited by 6 publications

References 26 publications

Bupropion-Induced Myoclonus: Case Report and Review of the Literature

Bupropion-Induced Myoclonus: Case Report and Review of the Literature

Single-Agent Bupropion Exposures: Clinical Characteristics and an Atypical Cause of Serotonin Toxicity

Bupropion overdose

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