Nonequilibrium interfacial diffusion across microdroplet interface

Khoeini, Davood; He, Vincent; Boyd, Ben J.; Neild, Adrian; Scott, Timothy F.

doi:10.1039/d2lc00326k

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…Droplets are widely used as micro-reaction chambers , and precursors for functional solid particles, − capsules, , and gels due to their advantages such as minimal consumption, a large specific surface area, and accurate dose control. Hydrogels, most of which are made with non-Newtonian droplets as precursors, can be used for wound dressing and drug release, such as sodium alginate (SA) and chitosan hydrogel. , However, conventional droplet preparation techniques often have disadvantages such as low monodispersity, poor controllability, and high energy consumption .…”

Section: Introductionmentioning

confidence: 99%

Shear-Thinning Fluid Droplets Formation in Axisymmetric Flow-Focusing Microfluidics

Cao,

Lu,

et al. 2024

Ind. Eng. Chem. Res.

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The formation of shear-thinning fluid [sodium alginate (SA) solution] droplets in a continuous Newtonian fluid phase is studied numerically. The influences of shear thinning effects on the interface evolution, flow regimes, droplet size, and formation frequency are examined. A regime diagram is summarized in terms of the Capillary number of the continuous phase (Ca) and the concentration of the shear-thinning fluid (c nN-f , the concentration of the SA solution). The results show that the regime transition from dripping to jetting caused by increasing Ca is delayed when the dispersed phase is a shear-thinning fluid, which is advantageous in the production of highly monodispersed droplets. Additionally, c nN-f shows a distinct influence on dripping and jetting regimes. In dripping regimes, increasing c nN-f results in decreased droplet size with a high formation frequency. This study provides a theoretical reference for the preparation of shearthinning fluid droplets and is also helpful in clarifying the formation mechanism of non-Newtonian droplets.

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Section: Introductionmentioning

confidence: 99%

Shear-Thinning Fluid Droplets Formation in Axisymmetric Flow-Focusing Microfluidics

Cao,

Lu,

et al. 2024

Ind. Eng. Chem. Res.

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“…In droplet microfluidics, immiscible fluids are merged to create a compartmentalized two-phase flow. Channel geometries and flow speeds can be used to vary the size and rate of production of the droplets ( 42 ). This size control has been used to create curved soft interfaces to indicate how the increasing curvature of the soft epithelial tissue in vivo promotes sperm capacitation and fertilization competence ( 43 ).…”

Section: Introductionmentioning

confidence: 99%

Making immotile sperm motile using high-frequency ultrasound

Vafaie,

Raveshi,

Devendran

et al. 2024

Sci. Adv.

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Sperm motility is a natural selection with a crucial role in both natural and assisted reproduction. Common methods for increasing sperm motility are by using chemicals that cause embryotoxicity, and the multistep washing requirements of these methods lead to sperm DNA damage. We propose a rapid and noninvasive mechanotherapy approach for increasing the motility of human sperm cells by using ultrasound operating at 800 mW and 40 MHz. Single-cell analysis of sperm cells, facilitated by droplet microfluidics, shows that exposure to ultrasound leads to up to 266% boost to motility parameters of relatively immotile sperm, and as a result, 72% of these immotile sperm are graded as progressive after exposure, with a swimming velocity greater than 5 micrometer per second. These promising results offer a rapid and noninvasive clinical method for improving the motility of sperm cells in the most challenging assisted reproduction cases to replace intracytoplasmic sperm injection (ICSI) with less invasive treatments and to improve assisted reproduction outcomes.

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“…The peculiarity of chemical reactions in the nanoscale space is treated as a "scale effect", but there is still little knowledge about the establishment of a reaction theory [16] that considers the reaction system and spatial factors and clearly shows their effects, and it is necessary to continue research on the basics (dissolution [17] and mixing at the interface [17,18], diffusion, surface tension [14], activation energy, solvent viscosity, the effects of electric and magnetic fields [19], self-assembling intermolecular interactions to form colloids [20,21], etc. ), while working toward application through the creation of useful functional materials.…”

Section: Introductionmentioning

confidence: 99%

Inversely Finding Peculiar Reaction Conditions toward Microfluidic Droplet Synthesis

Akitsu

2023

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With the development of microfluidics, there are increasing reports of syntheses using not only conventional laminar flow at the microscale, but also the dissociation and aggregation of microdroplets. It is known, to some extent, that the microfluidics scale differs from normal scales in terms of the specific surface area, mass diffusion, and heat conduction; these are opposite to those in scale-up in-plant chemical engineering. However, it is not easy to determine what changes when the microdroplet flows through the channel. In this context, the author would like to clarify how the behavior of chemical species, which is expected to appear unique at the nanoscale, contributes to chemical reactions. What do we need in order to develop a completely new theory of chemical reactions? The characteristics of chemical reactions on the nanoscale are clarified via the encountering of solutions by the microfluidic device itself, or the chemical reaction of nanoscale droplets generated by the microfluidic device. Specifically, in recent years, experimental reports have accumulated that are expected to develop a fluidic device that can stably generate nanodroplets, and complex reactions of different reactivity are expected to occur that are specific to the nanoscale. In this short article, microfluidic devices, nanoscale droplets, experimental synthetic examples, and findings that may provide solutions are described.

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Nonequilibrium interfacial diffusion across microdroplet interface

Abstract: Increases in complexity attainable in molecular self-assembly necessitates both advanced molecular design as well as exquisite microenvironmental control. Such control is offered by microfluidics, where precise chemical gradients and compositions...

Cited by 5 publications

References 38 publications

Shear-Thinning Fluid Droplets Formation in Axisymmetric Flow-Focusing Microfluidics

Shear-Thinning Fluid Droplets Formation in Axisymmetric Flow-Focusing Microfluidics

Making immotile sperm motile using high-frequency ultrasound

Inversely Finding Peculiar Reaction Conditions toward Microfluidic Droplet Synthesis

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