Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: Report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings

McGregor, Douglas H.; Mowry, Mark; Cherian, Rachel; McAnaw, Mary P.; Poole, Ed Gareth

doi:10.1016/0046-8177(95)90164-7

Cited by 37 publications

(13 citation statements)

References 9 publications

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“…A typical lesion is multiloculated with fibrous stroma and encapsulated by a thick fibrous wall lined with multinucleate giant cells 4 . The deposits are mainly composed of hydroxyapatite 5 . In the second patient, the prominent feature was cerebral calcifications, which caused neurological defects.…”

Section: Discussionmentioning

confidence: 96%

Intracranial calcification and tumoural calcinosis during vitamin D therapy

Seyahi¹,

Apaydın²,

Sariyar³

et al. 2004

Nephrology

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Extraskeletal calcifications are frequently observed in patients with chronic renal failure. However, clinically, they usually remain silent. In this report, we describe two patients with massive extraskeletal calcifications that caused significant morbidity. The first patient had tumoural calcification located on the shoulder and the second patient had severe neurological symptoms caused by intracranial calcifications. High calcium phosphorus product and severe secondary hyperparathyroidism were present in both patients. Furthermore, they both received inappropriately high doses of active vitamin D, even though they failed to respond to this therapy. We suggest to monitor closely the calcium, phosphorus and parathyroid hormone levels during calcitriol therapy and to perform parathyroidectomy, without delay, in patients who were resistant to calcitriol.

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Section: Discussionmentioning

confidence: 96%

Intracranial calcification and tumoural calcinosis during vitamin D therapy

Seyahi¹,

Apaydın²,

Sariyar³

et al. 2004

Nephrology

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“…Among the former, 'familial tumoral calcinosis' -non-familial cases are known, too (McGregor et al 1995) -is a disorderly reparative process which develops in the periarticular derma and is characterized by the formation of tumor-like calcified masses sometimes containing a milky, gritty material (for clinical symptoms, presentation and course, see Slavin et al 1993;Pakasa and Kalengayi 1997). Among the former, 'familial tumoral calcinosis' -non-familial cases are known, too (McGregor et al 1995) -is a disorderly reparative process which develops in the periarticular derma and is characterized by the formation of tumor-like calcified masses sometimes containing a milky, gritty material (for clinical symptoms, presentation and course, see Slavin et al 1993;Pakasa and Kalengayi 1997).…”

Section: Calcification Of the Skinmentioning

confidence: 99%

Biological Calcification

2007

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“…A few cases have provided immunohistochemical and microscopic findings from the resected soft tissue calcifications, indicating involvement of histiocytes and osteoclast-like giant cells of histiocyte origin. (6) The fever and systemic inflammatory response from TC could be associated with the release of cytokines and anti-inflammatory markers from these cells. A few reports have described bisphosphate use to prevent a systemic inflammatory response due to cytokine release from osteoclastic activity.…”

Section: Discussionmentioning

confidence: 99%

Fever as a Presentation of Tumoral Calcinosis: A Case Report

Nguyen¹,

Gúzman²,

Mesa³

et al. 2018

IJBM

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Tumoral calcinosis (TC) is a rare condition in which there is periarticular calcium deposition in the soft tissue forming a mass. The most common locations of TC are the larger joints such as the hip, shoulder, and knee, as well as the hands and wrists. Patients will often present with localized swelling, pain, and reduced joint mobility. We will discuss a 48-year-old male on hemodialysis who presented with a fever of unknown source and diffuse joint pain. He was found to have progressive, multiple tumor-like swellings on his shoulders, hands, and knees. He was diagnosed with TC and managed with a high dose phosphate binder with resolution of his fever and improvement in his pain.(International Journal of Biomedicine. 2018;8(1):75-78.)

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Nonfamilial tumoral calcinosis associated with chronic renal failure and secondary hyperparathyroidism: Report of two cases with clinicopathological, immunohistochemical, and electron microscopic findings

Cited by 37 publications

References 9 publications

Intracranial calcification and tumoural calcinosis during vitamin D therapy

Intracranial calcification and tumoural calcinosis during vitamin D therapy

Biological Calcification

Fever as a Presentation of Tumoral Calcinosis: A Case Report

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