Nonfluoroscopic, in vivo navigation and mapping technology

Ben‐Haim, Shlomo A.; Osadchy, Daniel; Schuster, Israel; Gepstein, Lior; Hayam, Gal; Josephson, M E

doi:10.1038/nm1296-1393

Cited by 354 publications

(201 citation statements)

References 10 publications

Supporting

Mentioning

197

Contrasting

Unclassified

Order By: Relevance

“…Because LELI by itself does not destroy any additional precious myocardial tissue, it will be suitable for catheter-based interventions alone or together with diagnostic intraventricular navigation procedures. 19 -21 It can be postulated that LELI can be delivered to the myocardium in humans via fiber optics in the catheter of the nonfluoroscopic in vivo navigation and mapping technology 19 currently in use in experimental animals and in humans. 20,21 The LELI energy can also be applied during or after the procedure of balloon angiography by use of a catheter with a central canal bearing a fiber optic, through which the laser energy can be delivered transversely (360°) to the infarcted area.…”

Section: Discussionmentioning

confidence: 99%

Low-Energy Laser Irradiation Reduces Formation of Scar Tissue After Myocardial Infarction in Rats and Dogs

et al. 2001

Self Cite

View full text Add to dashboard Cite

Background-Low-energy laser irradiation (LELI) has been found to attenuate various biological processes in tissue culture and experimental animal models. The aim of the present study was to investigate the effect of LELI on the formation of scar tissue in experimentally induced chronic infarct in rats and dogs. Methods and Results-Myocardial infarction (MI) was induced in 50 dogs and 26 rats by ligation of the left anterior descending coronary artery. After induction of MI, the laser-irradiated (LI) group received laser irradiation (infrared laser, 803-nm wavelength) epicardially. Control MI-induced non-laser irradiated (NLI) dogs were sham-operated, and laser was not applied. All dogs were euthanized at 5 to 6 weeks after MI. Infarct size was determined by TTC staining and histology. The laser treatment (PϽ0.05) lowered mortality significantly, from 30% to 6.5%, after induction of MI. The infarct size in the LI dogs was reduced significantly (PϽ0.0001) (52%) compared with NLI dogs. Histological observation of the infarct revealed a typical scar tissue in NLI dogs and cellularity in most of the LI dogs. Only 14Ϯ3% of the mitochondria in the cardiomyocytes in the ischemic zone (4 hours after MI) of LI MI-induced rats were severely damaged, compared with 36Ϯ1% in NLI rats. Accordingly, ATP content in that zone was 7.6-fold (significantly) higher in LI than in NLI rats. Conclusions-Our observations indicate that epicardial LELI of rat and dog hearts after chronic MI caused a marked reduction in infarct size, probably due to a cardioprotective effect of the LELI. Key Words: ischemia Ⅲ myocardial infarction Ⅲ antioxidants Ⅲ lasers T he approach to acute myocardial infarction (MI) has moved in the past decade from simple monitoring of coronary events to aggressive interventions in the processes underlying coronary thrombosis. Cardiac repair after infarct is a complex process involving diverse inflammatory components, extracellular matrix remodeling, and responses of the cardiomyocytes to the ischemia. 1,2 The sequential events that take place in the myocardium after occlusion of the left anterior descending coronary artery (LAD) in experimental animals (including dogs) have been well documented. 1,2 After necrosis of the cardiomyocytes and a rather long inflammatory phase, the ischemic zone is subsequently replaced by fibrotic tissue.Many studies have been directed toward the use of drugs, growth factors, and various interventional technologies in reducing myocardial infarct size and improvement of heart function after MI in experimental animals and humans. For example, recombinant adenovirus-mediated transfer of genes encoding antioxidants to the myocardium has been demonstrated to attenuate after ischemic dysfunction in neonatal mice. 3 Novel approaches to enhancing angiogenesis in the ischemic myocardium by introducing growth factors (mainly of the vascular endothelial growth factor family) were adapted and found to have a beneficial effect on patients with severe angina. 4 Low-energy laser irradiation (LELI) has b...

show abstract

Section: Discussionmentioning

confidence: 99%

Low-Energy Laser Irradiation Reduces Formation of Scar Tissue After Myocardial Infarction in Rats and Dogs

et al. 2001

Self Cite

View full text Add to dashboard Cite

show abstract

“…Kocher et al 6 transplanted 1ϫ10 6 freshly isolated EPCs/100-g rat. On a weight-adjusted basis, this would translate into 3ϫ10 8 to 6ϫ10 8 cells for an average-size human, requiring 8.5 to 120 L of peripheral blood. Although it may be possible to obtain enough EPCs from bone marrow in the clinical situation, it is a far from realistic strategy to isolate EPCs from peripheral blood by the previous methods.…”

Section: Conclusion-thesementioning

confidence: 99%

Intramyocardial Transplantation of Autologous Endothelial Progenitor Cells for Therapeutic Neovascularization of Myocardial Ischemia

et al. 2003

View full text Add to dashboard Cite

Background-We investigated whether catheter-based, intramyocardial transplantation of autologous endothelial progenitor cells can enhance neovascularization in myocardial ischemia. Methods and Results-Myocardial ischemia was induced by placement of an ameroid constrictor around swine left circumflex artery. Four weeks after constrictor placement, CD31ϩ mononuclear cells (MNCs) were freshly isolated from the peripheral blood of each animal. After overnight incubation of CD31ϩ MNCs in noncoated plates, nonadhesive cells (NA/CD31ϩ MNCs) were harvested as the endothelial progenitor cell-enriched fraction. Nonadhesive CD31Ϫ cells (NA/CD31Ϫ MNCs) were also prepared. Autologous transplantation of 10 7 NA/CD31ϩ MNCs, 10

show abstract

“…Electroanatomic mapping: Electroanatomic mapping of the right ventricular endocardium was performed with the CARTO system (Biosense Webster Inc., Diamond Bar, CA, USA) as previously described. 21) A 2-mm ring electrode catheter with a 4-mm solid distal-tip electrode (Navistar, Biosense Webster Inc.) was used as the mapping catheter. Bipolar signals were filtered at 30-400 Hz and displayed at 200 mm/second.…”

Section: Methodsmentioning

confidence: 99%

Clarifying the Arrhythmogenic Substrate for Brugada Syndrome Electroanatomic Mapping Study of the Right Ventricle

et al. 2011

View full text Add to dashboard Cite

SummaryThe right ventricular outflow tract (RVOT) is considered the arrhythmogenic region that gives rise to Brugada syndrome. To obtain a better understanding of this substrate, we performed electroanatomic mapping of the right ventricle (RV) in patients with Brugada syndrome.The RV was mapped electroanatomically with the CARTO system in 11 patients with asymptomatic Brugada syndrome but in whom ventricular fibrillation was induced by programmed ventricular stimulation, and in 5 control patients. The low voltage zone area (< 1.5 mV) was larger (16.1% versus 7.8%, P < 0.01) and the bipolar electrogram duration was greater (81.6 ± 7.8 ms versus 53.4 ± 5.6 ms, P < 0.01) in the patients with Brugada syndrome versus the control patients; the bipolar electrogram duration was greater in the septal portion and free wall of the RVOT.Our data suggest that regional endocardial conduction slowing based on structural abnormalities exists at the RVOT in Brugada syndrome. (Int Heart J 2011; 52: 290-294)

show abstract

Nonfluoroscopic, in vivo navigation and mapping technology

Cited by 354 publications

References 10 publications

Low-Energy Laser Irradiation Reduces Formation of Scar Tissue After Myocardial Infarction in Rats and Dogs

Low-Energy Laser Irradiation Reduces Formation of Scar Tissue After Myocardial Infarction in Rats and Dogs

Intramyocardial Transplantation of Autologous Endothelial Progenitor Cells for Therapeutic Neovascularization of Myocardial Ischemia

Clarifying the Arrhythmogenic Substrate for Brugada Syndrome Electroanatomic Mapping Study of the Right Ventricle

Contact Info

Product

Resources

About