Nonfunctional neuroendocrine tumor of the pancreas: Case report and review of the literature

Cano, Auxiliadora; García, Fernando L. de la Vega; Espinoza, Amparo E.; Bezies, N.; Trilla, Enrique; Portilla, J. De Leija

doi:10.1016/j.ijscr.2012.10.018

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…Pancreatic neuroendocrine tumors (PanNETs) are a rare, heterogeneous group of tumors arising from the neuroendocrine system and are classified as functional or non-functional (NF-PanNETs). 1 NF-PanNETs account for 60%–90% of PanNETs, tend not to secrete biologically active hormones or neuropeptides and have no characteristic symptoms. 2–4 More than 90% of resected PanNETs are grade 1 or grade 2 (G1/G2) tumors, 5 with a Ki67 index <20%.…”

Section: Introductionmentioning

confidence: 99%

Infiltrating pattern and prognostic value of tertiary lymphoid structures in resected non-functional pancreatic neuroendocrine tumors

Zhang

Wang

Han

et al. 2020

J Immunother Cancer

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BackgroundTertiary lymphoid structures (TLS) are associated with favorable survival and play a critical role in most solid tumors. However, investigations of TLS are lacking in patients with grade 1 or grade 2 (G1/G2) non-functional pancreatic neuroendocrine tumors (NF-PanNETs). This study aimed to investigate the presence, cellular composition, association with tumor-infiltrating immune cells, and prognostic value of TLS in G1/G2 NF-PanNETs.MethodsTumor tissues from a 182-patient Fudan cohort and a 125-patient external validation set were assessed by H&E staining, immunohistochemistry, and/or multispectral fluorescent immunohistochemistry.ResultsTLS were identified in more than one-third of patients with G1/G2 NF-PanNETs and were located peritumorally, either just outside the tumor tissue or in the stromal area. TLS were mainly composed of B-cell follicles with germinal centers and T-cell zones with dendritic cells. Kaplan-Meier analyses showed that the presence of TLS correlated with both longer recurrence-free survival (RFS, p<0.001) and overall survival (OS, p=0.001), but the number of TLS had no prognostic significance. Multivariate Cox-regression analyses demonstrated that the presence of TLS, WHO classification, and 8th edition American Joint Committee on Cancer (AJCC8th) tumor-node-metastasis (TNM) stage were independent prognostic factors for RFS (p=0.004, p=0.001, and p<0.001, respectively) and OS (p=0.009, p=0.008, and p=0.019, respectively). These results were confirmed using an external validation set. Finally, a nomogram incorporating the presence of TLS was constructed to predict the probability of 5-year RFS of resected G1/G2 NF-PanNETs, which improved on the current WHO classification and AJCC8th TNM stage.ConclusionsThe presence of TLS is an independent and favorable predictor of resected G1/G2 NF-PanNETs, which may play a role in cancer immunobiology.

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Section: Introductionmentioning

confidence: 99%

Infiltrating pattern and prognostic value of tertiary lymphoid structures in resected non-functional pancreatic neuroendocrine tumors

Zhang

Wang

Han

et al. 2020

J Immunother Cancer

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“…Панкреатические неоплазии обладают широкой вариабельностью клинических и морфологических особенностей [6]. В зависимости от наличия у пациентов клинического синдрома, вызванного гиперсекрецией гормонов, выделяют функционирующие и нефункционирующие опухоли.…”

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Surgical Management of Pancreatic Neuroendocrine Tumors

Егоров

Vasiliev

Kondrashin

et al. 2020

Tavricheskiy Mediko-Biologicheskiy Vestnik

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The incidence of pancreatic neuroendocrine tumors has significantly increased for the last decades. Patients with multiple pancreatic neuroendocrine tumors require special attention to the diagnosis and treatment algorithms. The aim is to show possible treatment approaches for patients with multiple pancreatic neuroendocrine tumors. Materials and methods. 26 patients with multiple pancreatic neuroendocrine tumors were managed in the abdominal surgery department of Sechenov University for the last 20 years. Results. The rate of multiple tumors was 9% for sporadic tumors and 36.5% among patients with MEN-1. Sensitivity of the imaging techniques was significantly lower than in solitary insulinomas. Most patients underwent parenchymasparing procedures. Total pancreatectomy was performed only in two cases. Conclusion. Accurate imaging and identification of hormone-secreting tumors allows to offer patients parenchyma-sparing surgery and to provide more personalized approach to the treatment of patients with multiple pancreatic neuroendocrine tumors.

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Rare diseases in clinical endocrinology: a taxonomic classification system

Marcucci

Cianferotti

Beck‐Peccoz

et al. 2014

J Endocrinol Invest

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This report provides a complete taxonomy to classify REMD of the adult. In the future, the creation of registries of rare endocrine diseases to collect data on cohorts of patients and the development of common and standardized diagnostic and therapeutic pathways for each rare endocrine disease is advisable. This will help planning and performing intervention studies in larger groups of patients to prove the efficacy, effectiveness, and safety of a specific treatment.

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Nonfunctional neuroendocrine tumor of the pancreas: Case report and review of the literature

Cited by 6 publications

References 14 publications

Infiltrating pattern and prognostic value of tertiary lymphoid structures in resected non-functional pancreatic neuroendocrine tumors

Infiltrating pattern and prognostic value of tertiary lymphoid structures in resected non-functional pancreatic neuroendocrine tumors

Surgical Management of Pancreatic Neuroendocrine Tumors

Rare diseases in clinical endocrinology: a taxonomic classification system

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