Nonfunctioning adrenal incidentalomas with cortisol post-dexamethasone suppression test &gt;0.9 µg/dL have a higher prevalence of cardiovascular disease than those with values ≤0.9 µg/dL

Araujo‐Castro, Marta; Ramírez, Paola Parra; Rojas-Marcos, Patricia Martín; Centeno, Rogelio García; Gimeno, Paola Gracia; Fernández-Ladreda, Mariana Tomé; Núñez, Miguel Antonio Sampedro; Higueruela, Cecilia; Lázaro, Cristina Robles

doi:10.1007/s12020-022-03228-z

Cited by 3 publications

(1 citation statement)

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“…In a study conducted by Castro et al it was shown that the prevalence of cardiovascular disease increased in patients with 1 mg-DST results above 0.9 µg/dL. [16] In another study on depression, which is also one of the cortisol-related diseases, it was shown that it is more frequently observed in patients with 1 mg-DST levels above 0.9 µg/dL. [17] In our study, similar to these studies, we showed that the optimal cutoff value for the 1 mg-DST level to predict the success of bariatric surgery was 0.97 µg/dL.…”

Section: Discussionmentioning

confidence: 99%

Assessing the predictive value of the suppressed 1 mg overnight dexamethasone suppression test in success of bariatric surgery

Şirikçi,

Kiraç,

Findikli

et al. 2024

Medicine

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Bariatric surgery has been proven to be a successful intervention for managing obesity. There are numerous studies in the literature aiming to predict the factors influencing the success of bariatric surgery. Our study aims to determine whether preoperative 1 mg overnight dexamethasone suppression test (1 mg-DST) serum cortisol levels can serve as predictors of the effectiveness of bariatric surgery in severe obese patients without Cushing syndrome. A total of 98 patients who underwent bariatric surgery were included in the study. The preoperative 1 mg-DST levels, insulin levels, thyroid function tests, and lipid profiles of the patients were recorded. The patients’ preoperative, postoperative 3rd, and 6th month weights were recorded and the percent total weight loss (%TWL) is calculated. Patients were categorized into 2 groups based on their TWL at 6 months. The 1 mg-DST results were significantly lower in the high-TWL-6 group (0.93 ± 0.37 μg/dL) compared to the low-TWL-6 group (1.09 ± 0.36 μg/dL, P = .040). Similarly, Homeostatic Model Assessment for Insulin Resistance values were lower in the high-TWL-6 group (5.63 ± 2.21) compared to the low-TWL-6 group (6.63 ± 2.55, P = .047). The optimal cutoff value found for 1 mg-DST level was 0.97 µg/dL, providing 50% sensitivity and 70% specificity. This study is the first to examine the predictive role of suppressed 1 mg-DST levels on postoperative weight loss in nondiabetic patients. The most prominent result of this study was that we observed a negative correlation between 1 mg-DST levels and %TWL.

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Section: Discussionmentioning

confidence: 99%