Nonhepatosplenic ?? T-cell lymphoma with initial testicular compromise

Abstract

We report here a case of nonhepatosplenic gammadelta T-cell lymphoma with undescribed initial localization in testis, without hepatosplenomegaly or adenopathies, and subsequent development in the maxillary sinus. The maxillar mass biopsy revealed a T-cell infiltration, and its immunologic characterization by flow cytometry showed a gammadelta T-cell phenotype (CD45+, CD3+, CD2+, TCR gammadelta+), without expression of CD7, CD5, CD1a, TdT, CD4, CD8, TCR alphabeta, or NK antigens (CD16, CD56, and CD57). Clonal gamma-chain gene rearrangement by polymerase chain reaction (PCR) was detected in testicular and maxillar biopsies. Epstein-Barr virus type 1 (EBV) sequences were detected by molecular biology in the biopsy material, suggesting that this oncogenic virus may play a role in the genesis of the clonal expansion of gammadelta T-cells. The patient was initially treated with standard chemotherapeutic protocols, with poor response and aggressive course.

Epstein-Barr virus-positive systemic NK/T-cell lymphomas in children: report of six cases

“…Nevertheless, rare cases of nasal, thyroid, testicle, gastrointestinal and pulmonary cd Tcell lymphomas have also been reported. 2,[40][41][42][43][44][45] Moreover, several cases of cd T-cell lymphoma with lymph node involvement have been documented. [46][47][48][49] Of the eight cases reported in the literature, four occurred in children or young adults, mainly of Asian origin, and had the same immunophenotype and EBV positivity as the present cases.…”

Histopathologic and Molecular Aspects of CD56+ Natural Killer/ T-Cell Lymphoma of the Testis

“…2 One additional publication reported on 3 cases of testicular NK or T-cell lymphoma, among which we have excluded 1 from the primary analysis for being CD56 -. 5 Three of the CD56 -tumors were EBV+ in the tumor cells 5,13,14 ; thus, rather than excluding these cases altogether, we have analyzed them separately. Eleven publications that contained reports of 16 apparently unique cases of testicular CD56 + NK/T-cell lymphoma satisfied the inclusion criteria for this study.…”

Gamma-Delta T-cell Lymphoma: An Overview

“…This indolent variety has been described previously as "ketrongoodman type" presenting as verrucoid lesions [53]. Mucosal and extranodal dissemination mainly to GI tract and nasopharynx are seen [66][67][68][69][70][71][72]. Widespread dissemination is rare and involvement if spleen, liver and bone marrow are infrequent.…”