Nonhepatosplenic γδ T-cell Lymphomas Represent a Spectrum of Aggressive Cytotoxic T-cell Lymphomas With a Mainly Extranodal Presentation

García‐Herrera, Adriana; Song, Joo Y.; Chuang, Shih Sung; Villamor, Neus; Colomo, Luís; Pittaluga, Stefania; Álvaro, Tomás; Rozman, Marı́a; González, Jazmín De Anda; Arrunategui, Ana María; Fernández, Eva; Gonzalvo, Elena; Estrach, Teresa; Colomer, Dolors; Raffeld, Mark; Gaulard, Philippe; Campo, Elı́as; Jaffe, Elaine S.; Martinez, Antonio

doi:10.1097/pas.0b013e31822067d1

Cited by 121 publications

(106 citation statements)

References 35 publications

(35 reference statements)

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“…Estimation of the γδ-TCR antibody is controversial. A study using the same antibody (TCR gamma+delta antibody clone 5A6.E9) can successfully recognize γδ-T-cells with membranous staining in formalin-fixed paraffin-embedded tissue, 22 but there was another one reporting that the antibody was not so robust. 23 Although membranous positive-staining of γδ-TCR is acceptable as positive, we need further study for γδ-TCR.…”

Section: Discussionmentioning

confidence: 99%

Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan

et al. 2015

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Enteropathy-associated T-cell lymphoma (EATL) is a rare primary T-cell lymphoma of the digestive tract. EATL is classified as either Type I, which is frequently associated with and thought to arise from celiac disease and is primarily observed in Northern Europe, and Type II, which occurs de novo and is distributed all over the world with predominance in Asia. The pathogenesis of EATL in Asia is unknown. We aimed to clarify the histological and genomic profiles of EATL in Japan in a homogeneous series of 20 cases. The cases were characterized by immunohistochemistry, high-resolution oligonucleotide microarray, and fluorescence in situ hybridization (FISH) at five different loci: 1q21.3 (CKS1B), 6q16.3 (HACE1), 7p22.3 (MAFK), 9q33.3 (PPP6C), and 9q34.3 (ASS1, CARD9) using formalin-fixed paraffin-embedded sections. The histological appearance of EATL ranged from medium-to large-sized cells in 13 cases (65%), small-to medium-sized cells in five cases (25%), and medium-sized in two cases (10%). The immunophenotype was CD2 + (60%), CD3e + (100%), CD4 + (10%), CD7 + (95%), CD8 + (80%), CD56 + (85%), TIA-1 + (100%), Granzyme B + (25%), T-cell receptor (TCR)β + (10%), TCRγ + (35%), TCRγδ + (50%), and double negative for TCR (six cases, 30%). All cases were EBER − . The genomic profile showed recurrent copy number gains of 1q32. 3, 4p15.1, 5q34, 7q34, 8p11.23, 9q22.31, 9q33.2, 9q34.13, and 12p13.31, and losses of 7p14.1. FISH showed 15 patients (75%) with a gain of 9q34.3 with good correlation with array comparative genomic hybridization. EATL in Japan is characterized by non-monomorphic cells with a cytotoxic CD8 + CD56 + phenotype similar to EATL Type II. The genomic profile is comparable to EATL of Western countries, with more similarity to Type I (gain of 1q and 5q) rather than Type II (gain of 8q24, including MYC). The 9q34.3 gain was the most frequent change confirmed by FISH irrespective of the cell origin of αβ-T-cells and γδ-T-cells.

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Section: Discussionmentioning

confidence: 99%

Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan

et al. 2015

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“…A recent study of type II EATL showed that about 80% expressed TCRgd [10], suggesting that it might be one example of the nonhepatosplenic gd T-cell lymphomas increasingly recognized [21]. Owing to the retrospective nature of this study, TCR immunophenotype was not available in all cases.…”

Section: Discussionmentioning

confidence: 99%

Type II enteropathy‐associated T‐cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group

et al. 2012

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Enteropathy-associated T-cell lymphoma (EATL) is a rare primary gastrointestinal T-cell lymphoma. A multicenter study from the Asia Lymphoma Study Group identified 38 EATL patients within a 19-year period. All cases were type II EATL. Men were affected twice as common as women, at a median age of 59 (23-89) years. None had a history of celiac disease. The sites of involvement were small bowel and stomach (5%), small bowel (63%), small and large bowel (16%), and large bowel (18%). Common presenting features were bowel perforation (34%), pain (32%), and obstruction (21%). Lymphomas showed monomorphic neoplastic lymphoid infiltrates that were CD3 1 (100%), CD56 1 (91%), TIA-1 1 (96%), CD4 -CD8 1 (63%), CD4 1 CD8 1 (19%), CD4 -CD8 -(16%), and CD4 1 CD8 -(3%). Epstein Barr virus was demonstrable in three cases. Despite chemotherapy and/or surgical resection, the overall response and complete response rates were poor at 46% and 38%. The median overall survival (OS) was 7 months and progression-free-survival (PFS) 1 month. Five patients underwent hematopoietic stem cell transplantation all were alive. Age and the prognostic index for peripheral T-cell lymphoma were not prognostically significant. Good performance status was associated with better OS (P 5 0.03), and response to initial treatment led to better OS and PFS (P < 0.001). Am. J. Hematol. 87:663-668, 2012. V

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“…in five cases. TCRc or TCRd was detected in all cases, with simultaneous expression of bF1 in one case [74,75]. All cases express cytotoxic granules that include granzyme B, perforin, and TIA-1.…”

Section: Primary Cutaneous CD T-cell Lymphomamentioning

confidence: 92%

“…Its histological findings are variable and include upper dermal infiltration with marked epidermotropism with ulceration of the epidermis, diffuse dermal infiltration, or involvement of the subcutis with a subcutaneous panniculitis-like pattern [74]. Most patients experience an aggressive clinical course with extranodal and nodal dissemination [74,75]. The identification of primary cutaneous cdTCL was difficult until the TCRc and TCRd antibodies for paraffinsection immunohistochemistry became available commercially.…”

Section: Primary Cutaneous CD T-cell Lymphomamentioning

confidence: 99%

Peripheral T cell lymphoma in Asia

Park

2014

Int J Hematol

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Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T-and NK-cell neoplasms, the incidence of which is higher in Asian countries than in Western countries. Although its etiology is mainly unknown, several risk factors (such as genetic factors, abnormal immunity, environmental factors, and infectious causes) have been proposed. PTCL are classified based on a combination of several parameters, including morphology, site of presentation, viral status, immunophenotype, and specific genetic alterations. Their classification is ongoing, with the emergence of new entities and refinement of existing entities because of the development of diagnostic markers and new genetic alterations. This review presents epidemiologic data for PTCL in Asia, together with recent progress in the pathology of PTCL compared with the WHO 2008 classification.Epidemiology T-and NK-cell lymphomas are uncommon: overall, they represent fewer than 25 % of all non-Hodgkin's lymphoma (NHL) [1][2][3]. The occurrence rates of various subtypes of T-and NK-cell lymphomas in Asia are significantly different from those observed in Western countries, and even among Asian countries. The incidence and distribution of T-and NK-cell lymphomas in several Asian countries is summarized in Fig. 1 and Table 1 [ [4][5][6][7][8][9][10][11][12][13][14][15].The frequencies of T-and NK-cell lymphomas seem to increase from West to East Asia. The occurrence rate of Tand NK-cell lymphomas are relatively low (\20 % of NHL) mainly in West Asia (Turkey 16.2 %, Iraq 19 %, and Kuwait 18 %) and South Asia (Pakistan 11.3 %, and India 20.2 %), but relatively high mainly in East Asia (China 32.5 %, Korea 22 %, and Japan 24.9 %) and Southeast Asia (Thailand 25 %). The proportion of T-and NK-cell lymphomas in Taiwan is very low (13.3 %) compared with that of other East Asian countries. Regarding the subtypes of T-and NK-cell lymphomas, two West (Turkey and Iraq) and one South (Pakistan) Asian countries share similar distribution patterns, presenting T lymphoblastic lymphoma (T-LBL) as the most common subtype, followed by peripheral T-cell lymphoma (PTCL) or anaplastic largecell lymphoma (ALCL). The frequency of mycosis fungoides/sezary syndrome (MF/SS) is very high in Kuwait. The distribution patterns of T-and NK-cell lymphomas in Thailand, Taiwan, and Korea are similar, whereas adult T-cell leukemia/lymphoma (ATLL) represents a high proportion of T-and NK-cell lymphomas in Japan. When ATLL is excluded, four countries (Thailand, Taiwan, Korea, and Japan) exhibit very similar patterns of subtype distribution of T-and NK-cell lymphomas. Extranodal NK/ T-cell lymphoma (ENKL) is frequent in China (48 %) and Korea (28.7 %), but is less frequent in Japan (10.4 %), as reported by a recent study performed by an international T-cell project [2]. In China, the frequency of T-or NK-cell lymphoma varies according to geographic region

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Nonhepatosplenic γδ T-cell Lymphomas Represent a Spectrum of Aggressive Cytotoxic T-cell Lymphomas With a Mainly Extranodal Presentation

Cited by 121 publications

References 35 publications

Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan

Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan

Type II enteropathy‐associated T‐cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group

Peripheral T cell lymphoma in Asia

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