Nonhuman Primate Models of Immunosenescence

Rivera, Andrea; Rais, Maham; Barr, Tasha; Arnold, Nicole; Sureshchandra, Suhas; Messaoudi, Ilhem

doi:10.1007/978-3-319-64597-1_80-1

Cited by 2 publications

(1 citation statement)

References 159 publications

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“…In old age, the physical resources to recover from stressors are potentially lower, which lead to avoidance strategies. Some studies revealed changes in the immune system of aged primates, which make them more susceptible to diseases or other stressors (Meyer, Kerns, Haberthur, & Messaoudi, 2012;Rivera et al, 2018). In Barbary macaques, the proportion of using facial displays over high intensity aggression is higher in aged females than younger females.…”

Section: Applying Psychological Theories To Primatesmentioning

confidence: 99%

Determinants of cognitive performance and social preferences across age in Barbary macaques (Macaca sylvanus)

Rathke¹

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Aging is a universal process that occurs in almost all organisms and is defined as a progressive decrease in physiological functioning. For centuries, researchers have been interested in aging processes and their consequences. This is partly due to the fact that the proportion of older adults in human societies worldwide has increased in recent decades.In addition to research on the physiological basis of aging, it becomes increasingly important to study social aging. With increasing age, the size of the social network often decreases, which can have an impact on health and mortality risk. Psychological theories have been developed that attempt to disentangle the factors that explain the declining sociality in old age. To better understand age-related changes during lifespan from an evolutionary perspective, comparative studies are essential. Due to a similar physiological and cognitive aging process in the absence of societal norms that shape social aging in human societies, non-human primates can provide valuable insights here.The aim of this dissertation was to establish a link between the psychology of aging and behavioural biology. For that purpose, I studied Barbary macaques (Macaca sylvanus) as a model species to determine whether comparable patterns also occur in non-human primates. Studying non-human primates allowed to explicitly test hypotheses derived from psychological theories and at the same time provides insights for new theory building. The

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Section: Applying Psychological Theories To Primatesmentioning

confidence: 99%

Determinants of cognitive performance and social preferences across age in Barbary macaques (Macaca sylvanus)

Rathke¹

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Declining neutrophil production despite increasing G-CSF levels is associated with chronic inflammation in elderly rhesus macaques

Fahlberg

Takahashi

et al. 2021

Journal of Leukocyte Biology

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Aging is characterized by a loss of bone marrow hematopoietic tissue, systemic chronic inflammation, and higher susceptibility to infectious and noninfectious diseases. We previously reported the tightly regulated kinetics and massive daily production of neutrophils during homeostasis in adult rhesus macaques aged 3 to 19 yr (equivalent to approximately 10 to 70 yr of age in humans). In the current study, we observed an earlier release of recently dividing neutrophils from bone marrow and greater in-group variability of neutrophil kinetics based on in vivo BrdU labeling in a group of older rhesus macaques of 20-26 yr of age. Comparing neutrophil numbers and circulating cytokine levels in rhesus macaques spanning 2 to 26 yr of age, we found a negative correlation between age and blood neutrophil counts and a positive correlation between age and plasma G-CSF levels. Hierarchic clustering analysis also identified strong associations between G-CSF with the proinflammatory cytokines, IL-1β and MIP-1α. Furthermore, neutrophils from older macaques expressed less myeloperoxidase and comprised higher frequencies of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) compared to the young adult macaques. In summary, we observed an earlier release from bone marrow and a reduced production of neutrophils despite the increased levels of plasma G-CSF, especially in the elderly rhesus macaques. This lower neutrophil production capacity associated with increased production of proinflammatory cytokines as well as an earlier release of less mature neutrophils and PMN-MDSCs may contribute to the chronic inflammation and greater susceptibility to infectious and noninfectious diseases during aging.

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Nonhuman Primate Models of Immunosenescence

Cited by 2 publications

References 159 publications

Determinants of cognitive performance and social preferences across age in Barbary macaques (Macaca sylvanus)

Determinants of cognitive performance and social preferences across age in Barbary macaques (Macaca sylvanus)

Declining neutrophil production despite increasing G-CSF levels is associated with chronic inflammation in elderly rhesus macaques

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