Nonhydrolyzable d‑phenylalanine-benzoxazole derivatives retain antitubercular activity

Pepi, Michael J.; Chacko, Shibin; Kopetz, Nicole; Boshoff, Helena I.; Cuny, Gregory D.; Hedstrom, Lizbeth

doi:10.1016/j.bmcl.2022.129116

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Peonidin is known to have antibacterial (Jeyaraj et al, 2023), antiinflammation, and antioxidant activity (Bonetti et al, 2017). Dphenylalanine-benzoxazole showed antibacterial activity against Mycobacterium tuberculosis (Pepi et al, 2022(Pepi et al, , 2023. 6-shogaol had antimicrobial, antioxidant (Ghasemzadeh et al, 2018), antiinflammation (Deb et al, 2019), antibiofilm, and antivirulence activity (Lee et al, 2018).…”

Section: Determination Of Fic Fl and CVmentioning

confidence: 99%

Ethnopharmacology study of medicinal plants utilization for antidiarrheal remedies by Tengger tribe in Tosari District, Indonesia

Ningsih,

Mandasari,

Pratama

et al. 2024

Pharmaciana

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Tengger is one of the tribes in East Java Province, Indonesia practising traditional medicine by using mantras and medicinal plants. A disease with a high incidence rate and widely treated with medicinal plants in Indonesia, including in Tosari District, Pasuruan Regency, is diarrhoea. To conserve traditional medicine, mainly the utilization of medicinal plants as anti-diarrhoea agents, it is necessary to develop a database that keeps up with technological advances. The study aimed to determine medicinal plants utilization for antidiarrheal remedies by the Tengger tribe in four villages of Tosari District, Pasuruan Regency, namely Wonokitri, Tosari, Ngadiwono, and Podokoyo. The study employed the snowball sampling method, which involved conducting semi-structured interviews. The result showed nine medicinal plants for traditional antidiarrheal remedies, with Musaceae (23%) as the most widely used plant family. Most informants used immature plant (56.25%) and fruits (89.58%). In addition, most plants were administered orally (98%) without specific compounding methods (76%). The value of Factor of the informant's consensus (Fic) of plants used for diarrhoea was 0.74. The highest Fidelity Level (FL) and Choice Value (CV) were obtained from Elaeocarpus longifolius Blume at 69% and 2.4, respectively. Based on the findings of the study, E. longifolius has the potential to be further investigated for development in antidiarrheal treatment.

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Section: Determination Of Fic Fl and CVmentioning

confidence: 99%

Ethnopharmacology study of medicinal plants utilization for antidiarrheal remedies by Tengger tribe in Tosari District, Indonesia

Ningsih,

Mandasari,

Pratama

et al. 2024

Pharmaciana

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“…Peonidin, D-phenylalaninebenzoxazole, 6-Shogaol, and Piperine each exhibit diverse pharmacological potential, positioning them as promising candidates for therapeutic applications. Of noteworthy mention, D-phenylalanine-benzoxazole, as underscored by recent studies by Pepi et al (2022Pepi et al ( , 2023, has garnered attention for its robust antitubercular properties.…”

Section: Phytochemical Compounds Of E Longifoliusmentioning

confidence: 99%

Ethnopharmacology of medicinal plants used by the Tenggerese community in Bromo Tengger Semeru National Park, Indonesia

BHAGAWAN,

EKASARI,

AGIL

2023

Biodiversitas

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Abstract. Bhagawan WS, Ekasari W, Agil M. 2023. Ethnopharmacology of medicinal plants used by the Tenggerese community in Bromo Tengger Semeru National Park, Indonesia. Biodiversitas 24: 5464-5477. Bromo Tengger Semeru National Park is a repository of biodiversity with profound cultural significance. The Tenggerese community residing within the park possesses rich ethnopharmacological knowledge, using medicinal plants for various ailments. This study aims to comprehensively explore the medicinal plant diversity, traditional uses, and potential pharmacological activities among the Tenggerese people. Ethnopharmacological data was gathered through interviews with informants in seven Tenggerese villages. Ethnopharmacological indices like Species Use Value (SUV) and Fidelity Level (FL) were calculated to identify the most important medicinal plants. Phytochemical analysis of selected medicinal plants was conducted using UPLC-QTOF-MS/MS, and its pharmacological potential was assessed through antibacterial tests. A total of 124 medicinal plant species from 54 families were documented. The Tenggerese community utilizes plants to treat diverse diseases, with reproductive healthcare being prominently featured. Elaeocarpus longifolius emerged as a key species with high SUV and FL values. Phytochemical analysis identified 25 compounds, including major and minor compounds, already known for their pharmacological activities elsewhere. Elaeocarpus longifolius extract showed inhibitor activity against both gram-positive and gram-negative bacteria. The findings contribute to bridging traditional knowledge and modern scientific research, offering potential avenues for the development of drug candidates from indigenous medicinal plants.

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Nonhydrolyzable d‑phenylalanine-benzoxazole derivatives retain antitubercular activity

Cited by 2 publications

References 9 publications

Ethnopharmacology study of medicinal plants utilization for antidiarrheal remedies by Tengger tribe in Tosari District, Indonesia

Ethnopharmacology study of medicinal plants utilization for antidiarrheal remedies by Tengger tribe in Tosari District, Indonesia

Ethnopharmacology of medicinal plants used by the Tenggerese community in Bromo Tengger Semeru National Park, Indonesia

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