Historical PerspectiveWhat is now called the OSA syndrome was initially described by Burwell in 1956 (Burwell, Robin, Whaley, & Bikelman, 1956. Burwell described an obese patient who presented with C02 retention, somnolence, and polycythemia. The fundamental pathogenesis was attributed to simple hypoventilation, secondary to obesity-related chest wall constriction. Burwell termed this the Pickwickian syndrome, after the character "Joe the fat boy" in the Dickens novel The Pickwick Papers. Joe the fat boy was a large, somnolent messenger boy who frequently was described as being extremely sleepy under a variety of inappropriate circumstances. It was not until several years later that individuals meeting the criteria of the Pickwickian syndrome as described by Burwell were found to actually have upper airway obstruction during sleep (Gastaut, Tassinari, & Duron, 1965). These authors described repeated episodes of upper airway obstruction in individuals with obesity, snoring, and symptoms of daytime somnolence. This work, and numerous subsequent studies, have inexorably lmked symptoms of snoring, obesity, and daytime sleepiness with sleep-related upper airway obstruction, or the OSA syndrome.Perhaps the sine qua non of this phenomenon is sonorous snoring. Snoring is a phenomenon that is ubiquitous among adult males and is noted in virtually all patients with OSA. Clinically, OSA patients often report a chronic history of loud snoring and a significant exacerbation in snoring within a few years of presentation to a physician.
Snoring as a Medical PhenomenonUntil recently, snoring was regarded as merely an annoyance confined primarily to the snorer's bed partner. It was the source of many jokes and of frustration among spouses but was rarely taken seriously by the medical community. The establishment of a link between snoring and a serious, if not potentially lethal, medical condition (i.e., OSA) has substantially altered the view of this symptom in the medical community. Certainly, snoring under certain circumstances must be taken seriously and regarded as the indication of a potentially serious medical problem. Epidemiologic studies, for example, have shown that chronic snorers have a predisposition to cardiovascular complications such as myocardial infarction and stroke (Lugaresi, Cirignotta, Montagna, & Sforza, 1994). In a prospective study of twins, those identified as habitual