Noninherited Risk Factors of Congenital Heart Defects in Offspring: A Revi

Mamun, Mohammad Abdullah Al; Hussain, Manzoor; Hasan, Md. Faruk; Rima, Rezoana

doi:10.3329/bjch.v41i1.33635

Cited by 1 publication

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“…CHDs are highly prevalent problems with mostly unknown origins. One study found that multiple environmental exposures for pregnant women, including living in newly renovated rooms, living in homes near major traffic, smoking, and having a manual labor occupation, were significantly associated with CHDs in their offspring (Mamun et al 2017 ). As shown in our study, both maternal living/working environment exposure and occupational exposure are risk factors for CHDs in offspring.…”

Section: Discussionmentioning

confidence: 99%

Maternal environmental, occupational, and urinary metabolite levels of benzene compounds and their association with congenital heart diseases in offspring: a case‒control study in China

Author)

Kang

et al. 2023

Environ Sci Pollut Res

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The conclusions about the association of maternal pregnancy environment, occupation, and benzene compounds with fetal CHD are not entirely consistent. Eight hundred seven CHD cases and 1008 controls were included in this study. All occupations were classified and coded against the Occupational Classification Dictionary of the People’s Republic of China (2015 version). Logistic regressions were used to explore the correlation among environmental factors, occupation types, and CHDs in offspring. We found that living near public facilities and having exposure to chemical reagents and hazardous substances were significant risk factors for CHDs in offspring. We found that offspring of mothers who worked in agriculture and similar work during pregnancy suffered from CHD. The risk of all CHDs in the offspring of pregnant women working in production manufacturing and related work was significantly higher than that in unemployed pregnant women, the risk was also observed in 4 subtypes of CHDs. We compared the concentrations of the five metabolite (MA, mHA, HA, PGA, and SPMA) levels of benzene compounds in the urine of mothers in case and control groups and found no significant differences. Our study suggests that maternal exposure during pregnancy and certain environmental and occupational conditions are risk factors for CHD in offspring, but did not support an association between concentrations of metabolites of benzene compounds in the urine of pregnant women and CHDs in their offspring.

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Section: Discussionmentioning

confidence: 99%