This study aims to develop an integrated approach for 3D lumbar vertebral biomodel design and analysis, specifically targeting unilevel disc degeneration and the replacement of lumbar artificial discs. Key objectives include improving existing design methods through 3D techniques, inverse modeling, and an engineering biomodel preparation protocol. Additionally, the study evaluates mechanical properties in the implantation area and between disc components to gauge the effectiveness of artificial discs in restoring functional movement within the studied biological model. The construction of a biological model representing the L3–L4 functional spinal unit was based on measurements from radiographic images and computed tomography data obtained from the study sample. The 3D finite element method in Ansys software (v. 19.2, ANSYS, Inc., Canonsburg, PA, USA) was used to monitor the distribution of equivalent stress values within the core of the two artificial discs and the behavior of vertebral bone components in the model. This approach enabled the creation of personalized digital models tailored to the specific implantation requirements of each patient. Stress analysis identified critical areas within the disc cores, suggesting potential design modifications to optimize artificial disc performance, such as selectively increasing core thickness in specific regions and considering adjustments during implantation. For example, preserving part of the lateral annulus fibrosus from the degenerative disc and maintaining the anterior and posterior longitudinal ligaments may play a crucial role in balancing the forces and moments experienced by the lumbar section. This study provides valuable insights into the development of patient-specific solutions for lumbar disc degeneration cases, with the potential for enhancing artificial disc design and implantation techniques for improved functional outcomes.