Noninvasive and minimally invasive carcinoma ex mixed tumor

Brandwein, Margaret; Huvos, Andrew G.; Dardick, Irving; Thomas, Meera; Theise, Neil D.

doi:10.1016/s1079-2104(96)80071-0

Cited by 119 publications

(24 citation statements)

References 7 publications

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“…It would be reasonable to speculate that the excellent prognosis of these lesions is associated with fact that they were removed at an early stage in their tumour progression, prior to the development of capsular invasion and metastatic potential. The authors of the present study concur with previous reports that pleomorphic adenoma with focal areas of malignant change should be carefully assessed by serial sectioning to document evidence of capsular invasion 3,14 . The prognosis and future therapy will depend on careful study of these lesions.…”

Section: Discussionsupporting

confidence: 90%

“…Previous reports of non-invasive (intracapsular) carcinoma ex pleomorphic adenoma, seem to suggest an excellent prognosis for these lesions, with no evidence of recurrence or metastasis if these lesions are completely excised 3,13,14 . They found the absence of capsular invasion correlated with a 'benign' clinical course of these neoplasms.…”

Section: Discussionmentioning

confidence: 86%

“…Though carcinoma ex pleomorphic adenoma accounts for approximately 12% of malignant salivary gland tumours, we are aware of only 15 previous cases of noninvasive (intra-capsular) carcinoma ex pleomorphic adenoma reported in the English literature 3,10,13,14 . In 9 of these cases the tumour arose in a major salivary Atypical features in pleomorphic adenoma-a clinicopathologic study and implications for management 611 gland and in the remaining 6 cases reported, the site of the tumour was not documented.…”

Section: Discussionmentioning

confidence: 99%

“…These include features of vascular invasion 1,6,23 , focal dysplasia 2,5 and non-invasive (intracapsular) carcinoma ex pleomorphic adenoma 3,10,13,14 . There is little information in the literature regarding how these different histological variants influence clinical presentation and outcome following primary treatment.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Atypical features in pleomorphic adenoma—a clinicopathologic study and implications for management

Ethunandan

Witton

Hoffman

et al. 2006

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Atypical features in pleomorphic adenoma—a clinicopathologic study and implications for management

Ethunandan

Witton

Hoffman

et al. 2006

International Journal of Oral and Maxillofacial Surgery

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confidence: 99%

Three Cases of Noninvasive Carcinoma ex Pleomorphic Adenoma of the Parotid Gland and a Literature Survey Focusing on their Clinicopathologic Features

Mori

Kunimura

Saito

et al. 2010

Showa Univ J Med Sci

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IntroductionOnly 30 cases of non-invasive intra-capsular carcinoma ex pleomorphic adenoma have been reported in the English language literature [1][2][3][4][5] . Here, we report three cases of noninvasive carcinoma ex pleomorphic adenoma and we have carried out a literature survey. Table 1-1, 1-2 Case Reports Case 1A 61-year-old man was admitted to hospital, presenting with a mass in the parotid gland. The prognosis and therapeutic appoach will depend on evidence of capsular invasion. HER-2/neu is a useful marker in the differential diagnosis of pleomorphic adenoma versus noninvasive carcinoma ex pleomorphic adenoma.

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Epithelial Lacrimal Gland Tumors

Weis

Rootman²,

Joly³

et al. 2009

Arch Ophthalmol

126

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To apply the updated epithelial salivary gland classification scheme to a large cohort of lacrimal gland tumors so as to provide an updated lacrimal gland tumor classification scheme. Methods: A retrospective multicenter cohort study of 118 cases of epithelial neoplasia was undertaken. Main outcome measures included pathologic analysis, subtyping, and survival. Results: Of 118 cases, 17 (14%) were reclassified using the proposed expanded classification scheme based on the current World Health Organization classification of salivary gland tumors. The most frequent neoplasms were pleomorphic adenoma and adenoid cystic carcinoma, of which we highlight more unusual histologic features. Three tumors were found to be unclassifiable with the updated scheme, with 2 having histologically malignant features. Deficiencies and variations in pathologic assessment were noted. Variation in the histologic findings of pleomorphic adenoma and assessment of the extent of invasion of carcinoma ex pleomorphic adenoma were highlighted. Conclusions: The use of the more histologically diverse classification of salivary gland tumors can be successfully applied to the epithelial lacrimal gland neoplasms. This expanded classification system led to reclassifying 14% of cases. Currently, there are no consistent pathologic standards for processing and evaluating these lesions.

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Noninvasive and minimally invasive carcinoma ex mixed tumor

Cited by 119 publications

References 7 publications

Atypical features in pleomorphic adenoma—a clinicopathologic study and implications for management

Atypical features in pleomorphic adenoma—a clinicopathologic study and implications for management

Three Cases of Noninvasive Carcinoma ex Pleomorphic Adenoma of the Parotid Gland and a Literature Survey Focusing on their Clinicopathologic Features

Epithelial Lacrimal Gland Tumors

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