Noninvasive Approaches to Diagnose Intrathoracic Extramedullary Hematopoiesis

Zade, Anand; Purandare, Nilendu; Rangarajan, Venkatesh; Shah, Sneha; Agrawal, Archi; Jha, Ashish Kumar; Kulkarni, Mukta

doi:10.1097/rlu.0b013e318251e19f

Cited by 10 publications

(3 citation statements)

References 10 publications

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“…A PET/CT scan may be diagnostically useful in such cases. To date, only a few cases regarding the diagnosis of EMH using PET/CT have been reported ( 17 , 18 ), with EMH detected as a benign mass with low SUV max values and normal appearance of the tissue. The concurrent presence of an underlying hematopoietic disorder may suggest a diagnosis of EMH.…”

Section: Discussionmentioning

confidence: 99%

Intrathoracic extramedullary hematopoiesis presenting as tumor-simulating lesions of the mediastinum in α-thalassemia: A case report

Weng

et al. 2015

Oncology Letters

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Extramedullary hematopoiesis (EMH) is a rare disease, where hematological disorder drives extramedullary hematopoietic tumor formation in multiple regions of the body. The present study reports a case of EMH presenting as multiple tumor-like lesions of mediastinum in a 61-year-old male with α-thalassemia, which was subjected to a video-assisted thoracoscopic surgery tissue biopsy to differentiate it from other mediastinal tumors. To date, only three cases of EMH in patients with α-thalassemia have been described in the literature. Patients with EMH typically exhibit no hematological disorder preoperatively and therefore EMH is frequently misdiagnosed. In the present study, along with a literature review of the clinicopathological features of EMH, the diagnosis and treatment of this rare case was discussed, in order to differentiate diagnosis, and particularly to distinguish EHM from extramedullary myeloid sarcoma.

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Section: Discussionmentioning

confidence: 99%

Intrathoracic extramedullary hematopoiesis presenting as tumor-simulating lesions of the mediastinum in α-thalassemia: A case report

Weng

et al. 2015

Oncology Letters

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“…The presacral space is recognized as a rare location for EMH 2 ; diagnosis of EMH was confirmed histologically on CT-guided biopsy. Conventionally, MRI is the recommended imaging modality for EMH 3 ; however, 18 F-FLT PET may offer unique advantages: (i) potential for quantitative functional assessment of highly proliferative EMH, (ii) whole-body images to identify synchronous sites of EMH, 4 (iii) noninvasive method of diagnosis for EMH, 5,6 and (iv) quantitative functional assessment of the distribution of proliferative bone marrow. [7][8][9] Further, 18 F-FLT PET may have utility for postradiotherapy functional response assessment of proliferative marrow 10,11 ; however, the applicability to EMH is unreported.…”

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confidence: 99%

18F-Fluorothymidine PET for Functional Response Assessment Following Radiation Therapy for Extramedullary Hematopoiesis

Campbell

Callahan²,

Cole‐Sinclair

et al. 2021

Clin Nucl Med

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As a marker of cellular proliferation, 18F-fluorothymidine (FLT) PET can detect the distribution of proliferating hematopoiesis and has an emerging role in the investigation of hematopoietic disorders. These images demonstrate the novel utility of 18F-FLT PET for imaging sites of extramedullary hematopoiesis (EMH) in a patient with Chuvash-type polycythemia and suggest a role for 18F-FLT PET in response assessment following radiotherapy. Further, the discordant response observed in the irradiated marrow and sites of EMH is a unique discovery, possibly suggesting the influence of the microenvironment favoring more rapid recovery of proliferative function within EMH sites.

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“…In diagnosis, PET/CT scan may be useful. So far, only a few cases have been reported with an EMH diagnosis, using PET/CT scan [5] and it can be considered as a benign mass with low SUV max values and normal appearance in the tissue. Concomitant presence of underlying hematopoietic disorder suggests EMH diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Intrathoracic extramedullary hematopoiesis as a posterior mediastinal tumor: a case report

Köse

Reyhan

Metin

et al. 2018

The European Research Journal

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Extramedullary hematopoiesis (EMH) is a rare disorder, defined as the appearance of hematopoietic elements outside the bone marrow or peripheral blood. Usually it is diagnosed incidentally and very rarely it presents as a posterior mediastinal mass clinically mimicking with many other benign or malignant mediastinal tumors. Intrathoracic EMH is a rare condition and only very few case reports have been described in patients with chronic myeloproliferative disorders specially myelofibrosis with myeloid metaplasia and spherocytic anemias. The paravertebral area is an uncommon site for EMH, with the possible exception of sporadically reported intrathoracic manifestations. In this study, a 38-year-old male patient was followed for myeloproliferative disease. Tumor-like lesions at the bilateral posterior mediastinum were detected in the patient who applied to our clinic due to fall. Excision was planned with video-assisted thoracoscopic surgery to differentiate from mediastinal tumors, but the mass unblock was removed with posterolateral thoracotomy because of the appearance of the lesion and large size. Histopathologic diagnosis was reported as extramedullary hematopoiesis. Patient was presented because of its rare location.

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Noninvasive Approaches to Diagnose Intrathoracic Extramedullary Hematopoiesis

Cited by 10 publications

References 10 publications

Intrathoracic extramedullary hematopoiesis presenting as tumor-simulating lesions of the mediastinum in α-thalassemia: A case report

Intrathoracic extramedullary hematopoiesis presenting as tumor-simulating lesions of the mediastinum in α-thalassemia: A case report

18F-Fluorothymidine PET for Functional Response Assessment Following Radiation Therapy for Extramedullary Hematopoiesis

Intrathoracic extramedullary hematopoiesis as a posterior mediastinal tumor: a case report

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