Background and Objectives: Structured physical activities and dietary control have traditionally been used with the aim of controlling obesity. However, effective auxiliary modalities still needed to reduce local obesity, specifically abdominal obesity. This study examined the adjunct effect of photobiomodulation therapy (PBMT), and non-contact selective-field radiofrequency (NcRF) on abdominal adiposity in adolescents with obesity. Study Design/Materials and Methods: Fifty-four adolescents with obesity (33 females and 21 males) took part in this study and were distributed randomly into three treatment-based groups. Control group (n = 18, age; 14.61 ± 1.14 years), PBMT group (n = 18, age; 14.22 ± 0.88 years), and NcRF group (n = 18, age; 15.11 ± 0.96 years). A dietary control plan of 1,000-1,200 kcal/day, and a 60-minute aerobic exercise program conducted day-by-day over 4 weeks were provided for all participants. Additionally, the PBMT group received 12 20-minute PBMT on the abdominal area (energy/session~4.08 J/cm 2) thrice/week, and the NcRF group underwent four 30-minute treatments with NcRF on the abdominal area once/week. Waist/hip ratio (W-to-H ratio), intra-abdominal fat thickness (IAFT), and the subcutaneousabdominal fat thickness (SAFT) were observed at the baseline and after 4 weeks. Results: The W-to-H ratio and SAFT reduced significantly in the PBMT group compared with either the control group (P = 0.001 and 0.001, respectively) or the NcRF group (P < 0.001 and P = 0.046, respectively) post-intervention. However, the IAFT and IAFT/SAFT ratio did not differ significantly among the study groups (P > 0.05). Conclusion: Our analysis shows that PBMT is more efficient than NcRF for the reduction of W-to-H ratio and SAFT in adolescents with obesity. Lasers Surg. Med.