Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method

Abstract

Marthan. Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method. J Appl Physiol 90: [2197][2198][2199][2200][2201][2202] 2001.-We describe a magnetic resonance (MR) imaging method that emphasizes pressure wave velocity to noninvasively assess pulmonary arterial hypertension. Both the blood flow and the corresponding vessel crosssectional area (CSA) were measured by MR phase mapping in the main pulmonary artery (MPA) in 15 patients. MPA pressures were also measured, in the same patients, by right-side heart catheterization. Two significant relationships were established: 1) between the pressure wave velocity in the MPA and the mean pressure in the MPA (Ppa) writing pressure wave velocity ϭ 9.25 Ppa Ϫ 202.51 (r ϭ 0.82) and 2) between the ratio of pressure wave velocity to the systolic blood velocity peak in the MPA (R) and the mean pressure in the MPA writing R ϭ 0.68 Ppa Ϫ 4.33 (r ϭ 0

Assessing normal pulse wave velocity in the proximal pulmonary arteries using transit time: A feasibility, repeatability, and observer reproducibility study by cardiovascular magnetic resonance

“…The positive relationship between age and pulmonary PWV was described previously (11). The absence of similar findings in our study can be explained by the limited number and small age range of the subjects.…”

“…Since this cannot be measured directly by CMR, established normal values were used in the study of healthy subjects (10), and ␦P was derived by an iterative process for patients with PAH (11). Second, a different group (13) was unable to predict the mPAP by right-heart catheterization using Laffron's currently proposed method (10,11). These concerns argue for continued investigation into other strategies.…”

Multimodality Noninvasive Imaging for Assessment of Congenital Heart Disease

“…86 Several investigators have attempted estimation of pulmonary artery pressure or resistance using CMR measures such as flow velocity, pressure wave velocity and acceleration time in the pulmonary artery, and end-systolic curvature of the ventricular septum. [87][88][89][90] However, none of these techniques have been adequately validated and none are currently in routine clinical use. Using specialized imaging suites that combine CMR measurement of blood flow with catheter-based pressure measurement, methods to estimate pulmonary vascular resistance and vascular compliance have also been described.…”

The Emerging Role of Magnetic Resonance Imaging in the Diagnosis and Management of Pulmonary Hypertension

“…A computed method for non-invasive MRI assessment of PAP has been suggested [74, 75], where a combination of variables including main pulmonary arterial blood flow velocity at peak systole, maximal systolic main pulmonary arterial cross-sectional area, patient height, weight and heart rate were used. However, the study design and the mathematical basis of this method have been questioned [76].…”