Background: Central obesity or increased intra-abdominal fat is associated with a statistically higher risk of heart disease, hypertension, insulin resistance, and diabetes mellitus type 2.Objective: This study was conducted to investigate and compare the effectiveness of tripollar radiofrequency lipolysis (RF), ultrasound (US) cavitation and their combination on abdominal subcutaneous fat thickness and waist circumference (WC) in patients with abdominal adiposity.Subjects: Thirty subjects suffering from localized fat deposits at the abdominal area with age ranged from 25-50 years old, BMI more than 30 kg/m 2 assigned randomly into three equal groups: Group (A) consisted of 10 subjects with mean age and BMI were 38.7±6.63 years and 33.55±1.31 kg/m 2 respectively. Group (B) consisted of 10 subjects with mean age and BMI were 34.3±7.76 years and 33.57±1.57kg/m 2 respectively. Group (C) consisted of 10 subjects with mean age and BMI were 34.3±7.76 years and 32.99±3.73 kg/m 2 respectively.Methods: Group (A) received US cavitation (AC 220 Volt. 40 KHz) twice weekly for 10 sessions. Group (B) received tripollar RF (AC 220 Volt .1MHZ. 50 Watts) twice weekly for 10 sessions. Group (C) received combination therapy (both tripollar RF and US cavitation) twice weekly for 10 sessions. Subjects in all groups were assessed using ultrasonography and tape measurement before treatment then after treatment after 10 sessions to measure subcutaneous fat thickness and WC.Results: Showed that there was statistical significant difference between pre and post treatment within each group (A, B and C) for abdominal subcutaneous fat thickness and WC. But there was a non-statistical significant difference between group A and group C; also, there was no statistical significant difference between group A and group B, while, there was a statistical significant difference between group B and group C in management of abdominal adiposity.Conclusion: Ultrasound cavitation, tripollar RF and their combination were effective methods for management of abdominal adiposity, but combination therapy were the most effective.