Noninvasive Brain Stimulation for Persistent Postconcussion Symptoms in Mild Traumatic Brain Injury

Koski, Lisa; Kolivakis, Theodore; Yu, Camilla; Chen, Jen‐Kai; Delaney, S.; Ptito, Alain

doi:10.1089/neu.2014.3449

Cited by 87 publications

(95 citation statements)

References 38 publications

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“…Thus, Koski et al 25 have hypothesised that rTMS over the DLPFC, which is an effective treatment for symptoms of major depressive disorder, may have utility in alleviating PPCS. In a study using a near-identical treatment protocol to the one described in this case, Koski et al showed a significant reduction in PPCS following 20 rTMS sessions in patients with mTBI with symptoms persisting for greater than 3 months 25…”

Section: Discussionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation (rTMS) as a treatment for chronic dizziness following mild traumatic brain injury

et al. 2018

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A 61-year-old man sustained a mild traumatic brain injury (mTBI) following a pedestrian versus vehicle traffic accident. Post injury, he began to experience symptoms including light-headedness, spatial disorientation, nausea, fatigue and prominent dizziness brought on by postural change, physical activity or eye movements. Symptoms of dizziness persisted for over 5 years, despite numerous extensive and rigorous vestibular and vision therapy regimens. All investigations suggested normal peripheral and central vestibular functioning. The patient underwent 10 sessions of repetitive transcranial magnetic stimulation (rTMS) treatment, with stimulation of the left dorsolateral prefrontal cortex at 70% of resting motor threshold and a frequency of 10 Hz. Dizziness symptom severity and frequency were reduced by greater than 50% at 3 months post treatment, with a clinically significant reduction of dizziness disability from 40 to 21 points on the Dizziness Handicap Inventory. We propose rTMS as a safe, effective and cost-effective treatment option for patients who experience persistent post-traumatic dizziness secondary to mTBI.

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Section: Discussionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation (rTMS) as a treatment for chronic dizziness following mild traumatic brain injury

et al. 2018

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“…52 Cortical activity induced by left prefrontal cortex anodal transcranial direct-current stimulation in patients with TBI correlated with improvements on neuropsychological tests.…”

Section: Neocortical Regionsmentioning

confidence: 97%

Neuromodulation for restoring memory

Bick¹,

Eskandar²

2016

FOC

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Disorders of learning and memory have a large social and economic impact in today's society. Unfortunately, existing medical treatments have shown limited clinical efficacy or potential for modification of the disease course. Deep brain stimulation is a successful treatment for movement disorders and has shown promise in a variety of other diseases including psychiatric disorders. The authors review the potential of neuromodulation for the treatment of disorders of learning and memory. They briefly discuss learning circuitry and its involvement in Alzheimer disease and traumatic brain injury. They then review the literature supporting various targets for neuromodulation to improve memory in animals and humans. Multiple targets including entorhinal cortex, fornix, nucleus basalis of Meynert, basal ganglia, and pedunculopontine nucleus have shown a promising potential for improving dysfunctional memory by mechanisms such as altering firing patterns in neuronal networks underlying memory and increasing synaptic plasticity and neurogenesis. Significant work remains to be done to translate these findings into durable clinical therapies.

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“…In a single uncontrolled small study, 4-week treatments with rTMS showed mild improvement in PCS but no change in cognitive function [174]. The exact mechanisms behind rTMS-induced plasticity are still unknown.…”

Section: Repetitive Transcranial Magnetic Stimulation (Rtms)mentioning

confidence: 99%

Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: current status and future directions

Hadanny

Efrati

2016

Expert Review of Neurotherapeutics

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Persistent post-concussion syndrome caused by mild traumatic brain injury has become a major cause of morbidity and poor quality of life. Unlike the acute care of concussion, there is no consensus for treatment of chronic symptoms. Moreover, most of the pharmacologic and non-pharmacologic treatments have failed to demonstrate significant efficacy on both the clinical symptoms as well as the pathophysiologic cascade responsible for the permanent brain injury. This article reviews the pathophysiology of PCS, the diagnostic tools and criteria, the current available treatments including pharmacotherapy and different cognitive rehabilitation programs, and promising new treatment directions. A most promising new direction is the use of hyperbaric oxygen therapy, which targets the basic pathological processes responsible for post-concussion symptoms; it is discussed here in depth.

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Noninvasive Brain Stimulation for Persistent Postconcussion Symptoms in Mild Traumatic Brain Injury

Cited by 87 publications

References 38 publications

Repetitive transcranial magnetic stimulation (rTMS) as a treatment for chronic dizziness following mild traumatic brain injury

Repetitive transcranial magnetic stimulation (rTMS) as a treatment for chronic dizziness following mild traumatic brain injury

Neuromodulation for restoring memory

Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: current status and future directions

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