Noninvasive Brain Stimulation for Rehabilitation of Pediatric Motor Disorders Following Brain Injury: Systematic Review of Randomized Controlled Trials

Elbanna, Samar Taher Elbasuony; Elshennawy, Shorouk; Ayad, Mona Nabil

doi:10.1016/j.apmr.2019.04.009

Cited by 23 publications

(23 citation statements)

References 56 publications

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“…The PEDro scale is a valid and reliable measure of the methodological quality of RCTs. This 10-item scale is based on core criteria for RCT quality assessment (Elbanna et al, 2019 ). Based on the PEDro scale, the quality of papers was classified as follows: studies with scores of lower than six points were considered low-quality studies, whereas studies with scores equal to or >6 points were considered high-quality studies (6–7 is good and 8–10 is excellent quality) (Maher et al, 2003 ).…”

Section: Methodsmentioning

confidence: 99%

Effects of rhythmic auditory stimulation on motor function and balance ability in stroke: A systematic review and meta-analysis of clinical randomized controlled studies

et al. 2022

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ObjectiveRhythmic auditory stimulation (RAS) belongs to neurologic music therapy, which has attracted clinical attention because of its efficacy in motor function after stroke. This study aimed to summarize the effectiveness of rhythmic auditory stimulation (RAS) for the treatment of motor function and balance ability in stroke through a systematic review and meta-analysis.MethodsAll studies were retrieved from six databases. The effects of RAS on stroke were determined using the following indicators: motor function including step length, step cadence, velocity, Fugl–Meyer assessment (FMA); and balance ability including overall balance index (OBI) and Berg Balance Scale (BBS). The risk map of bias of the quality of the studies and the meta-analysis results of the indicators was prepared using RevMan 5.2 software.ResultsA total of 1,363 abstracts were retrieved. Among them, 325 duplicate studies were eliminated, and 971 studies were excluded after reading the titles and abstracts. In addition, by downloading the full text for further reading and screening, 47 studies were excluded. A total of 22 studies were included in the systematic review, and 18 studies were included in the meta-analysis. Assessment of quality, based on the PEDro scale, two studies had low quality, three studies had excellent quality, and the other studies had good quality; based on the Cochrane Collaborative Network Bias Risk Assessment Scale. A total of 15 studies specifically explained the random methods used. Meanwhile, seven studies did not report random sequence generation. A total of 10 studies reported that the evaluation of experimental results was blinded. In the meta-analysis, the results of motor function [namely, velocity (SMD = 0.99, 95% CI (0.43, 1.55)), step length (SMD = 0.97, 95% CI (0.74, 1.20)), and step cadence (MD = 5.16, 95% CI (4.17, 6.14)), FMA (MD = 2.93, 95% CI (2.04, 3.83))], were statistically significant (P < 0.01). The results of balance ability [OBI (MD = −0.51, 95% CI (−0.86, −0.16)) and BBS (MD = 2.93, 95% CI (1.67, 4.20))], were also statistically significant (P < 0.01). Among all the outcome indicators, three indicators were included in more than 10 studies: these are step length, step cadence, and velocity. The results showed that the two sides of the funnel chart were asymmetrical, thus these results all showed heterogeneity. The GRADEpro GDT online tool was used to evaluate the quality of evidence for the outcome indicators in the included studies. Five outcome indicators were included, of which three were low-quality indicators and two were moderate-quality indicators.ConclusionsRAS could improve gait parameters, walking function, and balance ability of individuals with stroke. However, studies or samples of outcome indicators for balance ability of stroke patients is relatively insufficient, which also requires further research in the future.Systematic review registrationPROSPERO, identifier: CRD42021225102.

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Section: Methodsmentioning

confidence: 99%

Effects of rhythmic auditory stimulation on motor function and balance ability in stroke: A systematic review and meta-analysis of clinical randomized controlled studies

et al. 2022

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“…The frontal noninvasive brain stimulation can improve the negative symptoms of schizophrenia, etc., through RTMS and TDCS [ 47 ] [ 48 ]. An experiment on exercise rehabilitation in children with brain injury showed that noninvasive brain stimulation has some effect on the treatment of movement disorders in children with brain injury [ 49 ]. It was found that NIBS can safely stimulate children with brain injury, RTMS can improve upper limb function, TDCS can improve balance, and most gait variables continue to act for 1 month.…”

Section: Recent Development Of Noninvasive Methods For Robotic Contro...mentioning

confidence: 99%

Noninvasive Human-Computer Interface Methods and Applications for Robotic Control: Past, Current, and Future

Liu

Zhang

et al. 2022

Computational Intelligence and Neuroscience

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The purpose of this study is to explore the noninvasive human-computer interaction methods that have been widely used in various fields, especially in the field of robot control. To have a deep understanding of the development of the methods, this paper employs “Mapping Knowledge Domains” (MKDs) to find research hotspots in the area to show the future potential development. Through the literature review, this paper found that there was a paradigm shift in the research of noninvasive BCI technologies for robotic control, which has occurred from early 2010 since the rapid development of machine learning, deep learning, and sensory technologies. This study further provides a trend analysis that the combination of data-driven methods with optimized algorithms and human-sensory-driven methods will be the key areas for the future noninvasive method development in robotic control. Based on the above findings, the paper provides a potential developing way of noninvasive HCI methods for related areas including health care, robotic system, and media.

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“…The study revealed the effectiveness of tDCS in improving gait velocity {Mean Difference (MD) = 0.23; 95% CI [0.13, 0.34]; p < 0.0005}, stride length (MD = 0.10; 95% CI [0.05, 0.15]; p < 0.0005), and cadence (MD = 15.7; 95% CI [9.72,21.68]; p < 0.0005) (Saleem et al, 2019). Moreover, the meta-analysis of 10 studies, consisting of 306 participants with CP, showed noteworthy changes in all upper limb capacities (SMDs between 0.94 and 1.83; p = 0.0001) and balance (SMDs between −0.48 and 0.83; p < 0.05) (Elbanna et al, 2019). A systematic review and meta-analysis of tDCS treatment studies in children with aphasia, which included eight tDCS studies with 140 participants, revealed pooled SMD of 0.395 (p < 0.001) in favor of tDCS.…”

Section: Child Motor Dysfunctionmentioning

confidence: 97%

Transcranial Direct Current Stimulation in Treatment of Child Neuropsychiatric Disorders: Ethical Considerations

Auvichayapat

2022

Front. Hum. Neurosci.

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Transcranial direct current stimulation (tDCS) is a noninvasive electrical stimulation performed using low electric currents passing through two electrodes. The provided current passes from the anode to the cathode and induces electric fields in the surface neurons. It then modulates synaptic plasticity and finally changes cortical excitability or improves clinical outcomes, which outlast after a duration of stimulation. Meta-analyses have supported the beneficial effects of tDCS treatments in child neuropsychiatric disorders. However, the study of vulnerable children remains controversial and is a great deal for ethical considerations. Because the developing brain has some important physiological differences from the matured brain, specifically less γ-aminobutyric acid (GABA)ergic inhibition and more myelination, the opportunity to modify neurological disorders to be close to the normal level in childhood after tDCS is likely to be higher than in adults. In contrast, these physiological differences may result in unexpected excitability in children's brains and were criticized to have an unsafe effect, specifically seizures, which is a serious adverse events. As mentioned above, using tDCS in children appears to be a double-edged sword and should be ethically considered prior to wide use. Assessing between benefits of tDCS treatment within the golden period of brain development and the risk of seizure provocation is important. Thus, this perspective article is aimed to exhibit broad concepts about the developing brain, tDCS in children, pathophysiology of neuropsychiatric disorders and tDCS beneficence, tDCS safety and tolerability in children, and missing good opportunities or taking risks in tDCS.

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Noninvasive Brain Stimulation for Rehabilitation of Pediatric Motor Disorders Following Brain Injury: Systematic Review of Randomized Controlled Trials

Cited by 23 publications

References 56 publications

Effects of rhythmic auditory stimulation on motor function and balance ability in stroke: A systematic review and meta-analysis of clinical randomized controlled studies

Effects of rhythmic auditory stimulation on motor function and balance ability in stroke: A systematic review and meta-analysis of clinical randomized controlled studies

Noninvasive Human-Computer Interface Methods and Applications for Robotic Control: Past, Current, and Future

Transcranial Direct Current Stimulation in Treatment of Child Neuropsychiatric Disorders: Ethical Considerations

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