2017
DOI: 10.1002/cam4.1062
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Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging

Abstract: The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo biomarkers of tumor characteristics. We characterized three models of pancreatic cancer with multiparametric MRI techn… Show more

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Cited by 16 publications
(25 citation statements)
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“…However, T 1 and T 2 measures alone may not be sensitive enough to investigate the entire spectrum of tumor properties. Recently, diffusion weighted imaging (DWI) [ 14 , 15 ] and magnetization transfer imaging (MTI) [ 16 18 ] have been used as complementary imaging techniques to conventional MR measures to characterize adenocarcinoma. Finally, amide proton transfer (APT) imaging based on the chemical exchange saturation transfer (CEST) approach, which provides valuable information regarding the tumor microenvironment, has drawn considerable attention as a novel MRI contrast agent in the field of molecular imaging [ 19 , 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, T 1 and T 2 measures alone may not be sensitive enough to investigate the entire spectrum of tumor properties. Recently, diffusion weighted imaging (DWI) [ 14 , 15 ] and magnetization transfer imaging (MTI) [ 16 18 ] have been used as complementary imaging techniques to conventional MR measures to characterize adenocarcinoma. Finally, amide proton transfer (APT) imaging based on the chemical exchange saturation transfer (CEST) approach, which provides valuable information regarding the tumor microenvironment, has drawn considerable attention as a novel MRI contrast agent in the field of molecular imaging [ 19 , 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…MT could still prove to be useful in measurements of mdx mice because fatty tissue does not show MT due to the lack of water molecules [ 44 ]. Additionally, MT has been shown to be sensitive to fibrosis formation in other diseases such as Crohn’s disease [ 47 ] and pancreatic tumors [ 48 , 49 ]. Thus, measurements of MT in mdx 4cv mice at a young age could be further refined to capture early fibrotic tissue formation in young muscle as well as fibrosis seen in older mdx 4cv mice for useful translation to human studies of DMD where fatty infiltration and higher levels of fibrosis also occur in skeletal muscle.…”
Section: Discussionmentioning
confidence: 99%
“…Tumor desmoplasia is one of the common pathological features of human PDAC, characterized by dense fibrotic connective tissue that penetrates and envelopes the tumor (Li et al, 2012). These extracellular matrix is related with tumor progression, metastasis, and drug resistance (Farr et al, 2017). Hence, it is significantly important to characterize the tumor fibrosis to predict tumor grade and response to treatments.…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…The results demonstrated a significant difference between the ADC values of the tumor and pancreatic tissue. This can be explained by the accumulation of fibrotic tissue, which may be associated with restricted motion of the water protons (Farr et al, 2017).…”
Section: Accepted Manuscriptmentioning
confidence: 99%
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