Noninvasive delivery of siRNA into the epidermis by iontophoresis using an atopic dermatitis-like model rat

Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis

“…Shaved dorsal skins were excised from 10 week old male Sprague Dawley (SD) rats, and then held between the TCT TM devices (Kigasawa et al, 2010;Kigasawa et al, 2009) for in vitro iontophoresis (Fig. 1a).…”

Anti-cancer vaccination by transdermal delivery of antigen peptide-loaded nanogels via iontophoresis

“…Carriers such as liposomes and nanoparticles, which are used in the intravenous administration of drugs, can also be valuable in the transdermal delivery of antigens into the skin. Recently, we succeeded in the iontophoretic transdermal delivery of hydrophilic macromolecules, such as siRNA and CpG oligoDNA, and liposomes (Kigasawa et al, , 2010Kajimoto et al, 2011). Based on a mechanistic analysis, transdermal penetration of such macromolecules and nanoparticles induced by applying a small electric current was attributed to cleavage of the intercellular junction via Ca 2+ -mediated activation of cellular signaling (Hama et al, 2014).…”

Effect of Polyoxyethylene Alkyl Esters on Permeation Enhancement and Impedance of Skin

“…However, only about 20 drug molecules have been formulated successfully as transdermal products, due to the barrier property of SC (Subedi et al, 2010). In order to modify the SC and to increase the permeability, various methods have been developed, including chemical penetration enhancers, prodrugs, iontophoresis, electroporation, sonophoresis and microneedles (Ibrahim et al, 2010;Kigasawa et al, 2010). Among these methods, the simplest way to enhance the skin penetration of drug without any extra device is to incorporate the chemical enhancers into the formulation.…”