Noninvasive Dentistry: A Dream or Reality?

Clarkson, Brian H.; Exterkate, R.A.M.

doi:10.1159/000380887

Cited by 18 publications

(14 citation statements)

References 56 publications

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“…In the near future, novel nanotechnologies based on peptides and hydroxyapatite crystals together with biofilm engineering are expected to advance the noninvasive restorative options for moderate caries lesions 108,109 .…”

Section: [H2] Moderate Lesionsmentioning

confidence: 99%

Dental caries

Pitts

Zero

Marsh

et al. 2017

Nat Rev Dis Primers

1,274

958

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Dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that results in the phasic demineralization and remineralization of dental hard tissues. Caries can occur throughout life, both in primary and permanent dentitions, and can damage the tooth crown and, in later life, exposed root surfaces. The balance between pathological and protective factors influences the initiation and progression of caries. This interplay between factors underpins the classification of individuals and groups into caries risk categories, allowing an increasingly tailored approach to care. Dental caries is an unevenly distributed, preventable disease with considerable economic and quality-of-life burdens. The daily use of fluoride toothpaste is seen as the main reason for the overall decline of caries worldwide over recent decades. This Primer aims to provide a global overview of caries, acknowledging the historical era dominated by restoration of tooth decay by surgical means, but focuses on current, progressive and more holistic long-term, patient-centred, tooth-preserving preventive care.

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Section: [H2] Moderate Lesionsmentioning

confidence: 99%

Dental caries

Pitts

Zero

Marsh

et al. 2017

Nat Rev Dis Primers

1,274

958

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“…Consequently, the enamel layer of erupted teeth cannot regenerate and is supposed to last life-long. Approaches to regenerate destroyed enamel are an emerging field in regenerative dentistry and are the subject of the work of several research groups [ 9 - 11 ].…”

Section: Introductionmentioning

confidence: 99%

Overview of Calcium Phosphates used in Biomimetic Oral Care

Meyer¹,

Amaechi²,

Fabritius³

et al. 2018

TODENTJ

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Background:The use of biomimetic agents is an emerging field in modern oral care. Promising biomimetic substances for such applications are calcium phosphates, because their chemical composition is very similar to that of the mineral phase in human teeth, especially of natural enamel. Examples for their application include the remineralization of early caries lesions and repair of small enamel defects.Objective:This review provides an interdisciplinary view on calcium phosphates and their applications in biomimetic oral care. The aim of this work is to give an overview of in vivo and in situ studies comparing several calcium phosphates in preventive dentistry that can be used as a knowledge base for the development of innovative alternative oral care concepts.Methods:Books, reviews, and original research papers with a focus on in vivo and in situ studies were included. The databases PubMed® and SciFinder® were used for literature search. Calcium phosphates that are frequently utilized in oral care products are covered in this review and were used as search terms alone and together with the following key words: in vivo, in situ, caries, clinical study, and remineralization. From 13,470 studies found, 35 studies complied with the inclusion criteria and were used for this review.Results:Published in vivo and in situ studies demonstrate calcium phosphates’ potential in enamel remineralization. However, more studies are needed to further substantiate existing results and to extend and refine the application of calcium phosphates in modern oral care.Conclusion:Calcium phosphates represent an innovative biomimetic approach for daily oral care because of their high similarity to natural enamel that will broaden the range of future treatments in preventive dentistry.

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“…The 5D Caries Management Cycle Rules (CMCR), by analogy to the Deming Plan-Do-Check-Act behavioural approach, is presented in Figure 1c. Before cavitation symptoms become apparent, preventive measures should be taken to detect caries at the earliest possible stages of the disease (Figure 1d), with proper risk assessment and determination of adequate actions with an appropriate frequency of reminders [36][37][38][39]. Visually, changes in enamel, dentine, and pulp allow for the separation of three primary grades of caries severity [40,41].…”

mentioning

confidence: 99%

Virtual Approach to the Comparative Analysis of Biomaterials Used in Endodontic Treatment

Dobrzańska¹,

Dobrzański²,

Gołombek

et al. 2021

Processes

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The importance of endodontics is presented within our own concept of Dentistry Sustainable Development (DSD) consisting of three inseparable elements; i.e., Advanced Interventionist Dentistry 4.0 (AID 4.0), Global Dental Prevention (GDP), and the Dentistry Safety System (DSS) as a polemic, with the hypothesis of the need to abandon interventionist dentistry in favour of the domination of dental prevention. In view of the numerous systemic complications of caries that affect 3−5 billion people globally, endodontic treatment effectively counteracts them. Regardless of this, the prevention of oral diseases should be developed very widely, and in many countries dental care should reach the poorest sections of society. The materials and methods of clinical management in endodontic procedures are characterized. The progress in the field of filling materials and techniques for the development and obturation of root canals is presented. The endodontics market is forecast to reach USD 2.1 billion in 2026, with a CAGR of 4.1%. The most widely used and recognized material for filling root canals is gutta-percha, recognized as the “gold standard”. An alternative is a synthetic thermoplastic filler material based on polyester materials, known mainly under the trade name Resilon. There are still sceptical opinions about the need to replace gutta-percha with this synthetic material, and many dentists still believe that this material cannot compete with gutta-percha. The results of studies carried out so far do not allow for the formulation of a substantively and ethically unambiguous view that gutta-percha should be replaced with another material. There is still insufficient clinical evidence to formulate firm opinions in this regard. In essence, materials and technologies used in endodontics do not differ from other groups of materials, which justifies using material engineering methodology for their research. Therefore, a detailed methodological approach is presented to objectify the assessment of endodontic treatment. Theoretical analysis was carried out using the methods of procedural benchmarking and comparative analysis with the use of contextual matrices to virtually optimize the selection of materials, techniques for the development and obturation of root canals, and methods for assessing the effectiveness of filling, which methods are usually used, e.g., in management science, and especially in foresight research as part of knowledge management. The results of these analyses are presented in the form of appropriate context matrices. The full usefulness of the research on the effectiveness and tightness of root canal filling using scanning electron microscopy is indicated. The analysis results are a practical application of the so-called “digital twins” approach concerning the virtual comparative analysis of biomaterials used in endodontic treatment.

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Noninvasive Dentistry: A Dream or Reality?

Cited by 18 publications

References 56 publications

Dental caries

Dental caries

Overview of Calcium Phosphates used in Biomimetic Oral Care

Virtual Approach to the Comparative Analysis of Biomaterials Used in Endodontic Treatment

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