1999
DOI: 10.1016/s0895-7061(98)00173-3
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Noninvasive detection of vascular dysfunction in alcoholic patients

Abstract: Vasodilation is impaired in various conditions, such as hypercholesterolemia and tobacco use. We evaluated brachial artery flow-mediated vasodilation (FMD) after blood pressure (BP) cuff occlusion using high-resolution B-mode ultrasound in 20 alcoholics, without any coexisting conditions such as smoking, hypertension, or cholesterolemia, after a 3-month period of abstinence. They were compared with a control group of 20 alcohol-free healthy subjects. We measured the diameter of the brachial artery under baseli… Show more

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Cited by 51 publications
(29 citation statements)
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“…Several studies found that ED is a marker of the development of atherosclerosis; 8 this finding is probably related to the unbalance of endothelial factors, caused by a predominance of proatherosclerotic endothelial factors over the ones that promote antiatherosclerotic phenomena. Many reports have also demonstrated that the presence of ED is associated to cardiovascular risk factors such as diabetes mellitus, 24 hypertriglyceridemia, 25 smoking, 26 hyperhomocysteinemia, 27 and even alcoholism 28 and mental stress. 29 ED has been also demonstrated both in coronary and peripheral circulation of patients with SEH.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies found that ED is a marker of the development of atherosclerosis; 8 this finding is probably related to the unbalance of endothelial factors, caused by a predominance of proatherosclerotic endothelial factors over the ones that promote antiatherosclerotic phenomena. Many reports have also demonstrated that the presence of ED is associated to cardiovascular risk factors such as diabetes mellitus, 24 hypertriglyceridemia, 25 smoking, 26 hyperhomocysteinemia, 27 and even alcoholism 28 and mental stress. 29 ED has been also demonstrated both in coronary and peripheral circulation of patients with SEH.…”
Section: Discussionmentioning
confidence: 99%
“…Experiments performed in animal models and cultured endothelial cells indicate that alcohol modulates both endothelin (13,14) and nitric oxide (14,15) production, an effect that might be related to the demonstration of an impaired endothelium-dependent vasodilatation in chronic alcohol abusers (16). In both heavy alcohol consumers and cultured endothelial cells, we have recently demonstrated that alcoholinduced endothelial changes are associated with activation of oxidative stress (14), as ascertained by detection of decreased intracellular glutathione and increased malondialdehyde concentrations.…”
Section: Introductionmentioning
confidence: 90%
“…31,32 Thus, salt sensitivity of BP could contribute to the relationship of BP levels to the previous alcohol consumption in detoxified alcoholics, 26 although the nature of this association cannot be explained by the present study. Individuals with salt-sensitive essential hypertension and chronic alcoholism show other similarities such as a hyperactivity of the sympathetic nervous system, 17,18,31,32,45,46 an insulin-resistant state with hyperinsulinemia, 31,32,46,47 and an impaired endothelium-dependent vasorelaxation, 29,48 which is detectable even after abstaining from alcohol for 3 months. In addition, salt sensitivity in essential HTN seems to be an independent risk factor for the development of cardiovascular and renal complications.…”
Section: Gennaro Et Al Sodium Sensitivity and Alcoholism 871mentioning
confidence: 99%
“…28 Finally, an impaired endothelium-dependent vasorelaxation was found at 3 months in abstaining chronic alcoholics. 29 These findings would collectively indicate that some mechanisms of BP dysregulation secondary to previous alcohol exposure are operating even after medium-term alcohol detoxification. Our preliminary observations in long-term (6 to 12 months) detoxified alcoholics 30 showed a unexpected prevalence of low to normal plasma renin activity (PRA).…”
mentioning
confidence: 91%