Noninvasive determination of spatial distribution and temporal gradient of wall shear stress at common carotid artery

Sui, Binbin; Gao, Peiyi; Yang, Lin; Qin, Haiqiang; Ling, Liansheng; Liu, Guangrui

doi:10.1016/j.jbiomech.2008.07.026

Cited by 17 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The values of both parameters are in the same range of order of magnitude for all IFCs. The mean of the peak TWSSGs quoted by Sui et al, 33.23 Pa/s [47], is similar to the peaks of all non-Newtonian models in Fig. 5, ranging between 16.8 and 25.2 Pa/ s of IFCs 2 and 3.…”

Section: Discussionsupporting

confidence: 83%

“…5, ranging between 16.8 and 25.2 Pa/ s of IFCs 2 and 3. Flow separation in the study by Sui et al [47], similar to the flow under consideration is observed to be causing the fluctuations in WSS.…”

Section: Discussionmentioning

confidence: 82%

“…Therefore, the uncoupled models demonstrate an over-estimation of the TWSSG and WSS magnitudes by up to 100%, due to neglect of the local RBC concentration. A quantitative comparison can be made of the absolute values of the WSS and TWSSG with a non-invasive experimental study by Sui et al [47] of flow in the carotid arteries in-vivo in young healthy individuals. The values of both parameters are in the same range of order of magnitude for all IFCs.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Wall shear stress variations and unsteadiness of pulsatile blood-like flows in 90-degree bifurcations

Wyk

Wittberg

Fuchs

2013

Computers in Biology and Medicine

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Wall shear stress variations and unsteadiness of pulsatile blood-like flows in 90-degree bifurcations

Wyk

Wittberg

Fuchs

2013

Computers in Biology and Medicine

View full text Add to dashboard Cite

“…For simplicity, axisymmetric, fully developed velocity profiles are commonly assumed at the flow inlets based on the measured or assumed flow rates. However, recent reports of phase-contrast MRI measurements at the CCA have revealed that the majority of CCA velocity profiles are skewed, often exhibiting the crescent shape characteristic of strong Dean-type flow in a curved tube [2,3]. The common assumption of fully developed or axisymmetric flow in image-based CFD analysis may therefore introduce errors in the estimation of flow structure and wall shear rates at the bifurcation, as well as masking potentially important nonuniform wall shear variations at the CCA itself.…”

Section: Introductionmentioning

confidence: 99%

Effect of Common Carotid Artery Inlet Length on Normal Carotid Bifurcation Hemodynamics

Hoi

Wasserman

Lakatta

et al. 2010

Journal of Biomechanical Engineering

View full text Add to dashboard Cite

Controversy exists regarding the suitability of fully developed versus measured inlet velocity profiles for image-based computational fluid dynamics (CFD) studies of carotid bifurcation hemodynamics. Here, we attempt to resolve this by investigating the impact of the reconstructed common carotid artery (CCA) inlet length on computed metrics of “disturbed” flow. Twelve normal carotid bifurcation geometries were reconstructed from contrast-enhanced angiograms acquired as part of the Vascular Aging—The Link That Bridges Age to Atherosclerosis study (VALIDATE). The right carotid artery lumen geometry was reconstructed from its brachiocephalic origin to well above the bifurcation, and the CCA was truncated objectively at locations one, three, five, and seven diameters proximal to where it flares into the bifurcation. Relative to the simulations carried out using the full CCA, models truncated at one CCA diameter strongly overestimated the amount of disturbed flow. Substantial improvement was offered by using three CCA diameters, with only minor further improvement using five CCA diameters. With seven CCA diameters, the amounts of disturbed flow agreed unambiguously with those predicted by the corresponding full-length models. Based on these findings, we recommend that image-based CFD models of the carotid bifurcation should incorporate at least three diameters of CCA length if fully developed velocity profiles are to be imposed at the inlet. The need for imposing measured inlet velocity profiles would seem to be relevant only for those cases where the CCA is severely truncated.

show abstract

“…Similar results for the CCA profile were recently reported. 7,8 In the ECA, the velocity profile is also skewed laterally, with velocities near the medial wall being higher than those near the lateral wall. The opposite was observed in the ICA, where the velocity profile was skewed medially, but with higher velocities measured near the lateral wall than the medial wall.…”

Section: Discussionmentioning

confidence: 99%

In vivo three-dimensional blood velocity profile shapes in the human common, internal, and external carotid arteries

Kamenskiy

Dzenis

MacTaggart

et al. 2011

Journal of Vascular Surgery

View full text Add to dashboard Cite

The in vivo hemodynamics of the human carotid artery are different from those used in most current computer-based and in vitro models. The new information on three-dimensional blood velocity profiles can be used to design models that more closely replicate the actual hemodynamic conditions within the carotid bifurcation. Such models can be used to further improve our understanding of the pathophysiologic processes leading to stroke and for the rational design of medical and interventional therapies.

show abstract

Noninvasive determination of spatial distribution and temporal gradient of wall shear stress at common carotid artery

Cited by 17 publications

References 27 publications

Wall shear stress variations and unsteadiness of pulsatile blood-like flows in 90-degree bifurcations

Wall shear stress variations and unsteadiness of pulsatile blood-like flows in 90-degree bifurcations

Effect of Common Carotid Artery Inlet Length on Normal Carotid Bifurcation Hemodynamics

In vivo three-dimensional blood velocity profile shapes in the human common, internal, and external carotid arteries

Contact Info

Product

Resources

About