Noninvasive EEG Recordings from Freely Moving Piglets

Camp, Nora Vanessa de; Dietze, Silke; Klaßen, Markus; Bergeler, Jürgen

doi:10.3791/58226

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Such scalp recordings enable the study of acute effects of TBI or therapies for brain insults ( Wang et al, 2014 ; Atlan and Margulies, 2019 ; Barata et al, 2019 ). Similarly, telemetric EEG devices can be temporarily placed on the head, allowing the piglet to ambulate freely while awake or sleeping ( de Camp et al, 2018 ). However, the labor required to apply, record, and remove EEG may be cost prohibitive if extended to several months and may also interfere with normal behavior.…”

Section: Discussionmentioning

confidence: 99%

Robust, Long-Term Video EEG Monitoring in a Porcine Model of Post-Traumatic Epilepsy

Martinez-Ramirez

Slate

Price

et al. 2022

eNeuro

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To date, post-traumatic epilepsy (PTE) research in large-animal models has been limited. Recent advances in neocortical microscopy have made possible new insights into neocortical PTE. However, it is very difficult to engender convincing neocortical PTE in rodents. Thus, large-animal models that develop neocortical PTE may provide useful insights that also can be more comparable to human patients. Because gyrencephalic species have prolonged latent periods, long-term video EEG recording is required. Here, we report a fully subcutaneous EEG implant with synchronized video in freely ambulatory swine for up to 13 months during epileptogenesis following bilateral cortical impact injuries or sham surgery The advantages of this system include the availability of a commercially available system that is simple to install, a low failure rate after surgery for EEG implantation, radiotelemetry that enables continuous monitoring of freely ambulating animals, excellent synchronization to video to EEG, and a robust signal-to-noise ratio. The disadvantages of this system in this species and age are the accretion of skull bone, which entirely embedded a subset of skull screws and EEG electrodes, and the inability to rearrange the EEG electrode array. These disadvantages may be overcome by splicing a subdural electrode strip to the electrode leads so that skull growth is less likely to interfere with long-term signal capture and by placing two implants for a more extensive montage. This commercially available system in this bilateral cortical impact swine model may be useful to a wide range of investigators studying epileptogenesis in PTE.

show abstract

Section: Discussionmentioning

confidence: 99%

Robust, Long-Term Video EEG Monitoring in a Porcine Model of Post-Traumatic Epilepsy

Martinez-Ramirez

Slate

Price

et al. 2022

eNeuro

View full text Add to dashboard Cite

show abstract

Robust, long-term video EEG monitoring in a porcine model of post-traumatic epilepsy

Ramirez

Slate

Price

et al. 2022

Preprint

View full text Add to dashboard Cite

To date, post-traumatic epilepsy (PTE) research in large animal models has been limited. Recent advances in neocortical microscopy have made possible new insights into neocortical PTE. However, it is very difficult to engender convincing neocortical PTE in rodents. Thus, large animal models that develop neocortical PTE may provide useful insights that also can be more comparable to human patients. Because gyrencephalic species have prolonged latent periods, long-term video EEG recording is required. Here, we report a fully subcutaneous EEG implant with synchronized video in freely ambulatory swine for up to 14 months during epileptogenesis following bilateral cortical impact injuries or sham surgery The advantages of this system include the availability of a commercially available system that is simple to install, a low failure rate after surgery for EEG implantation, radiotelemetry that enables continuous monitoring of freely ambulating animals, excellent synchronization to video to EEG, and a robust signal to noise ratio. The disadvantages of this system in this species and age are the accretion of skull bone which entirely embedded a subset of skull screws and EEG electrodes, and the inability to rearrange the EEG electrode array. These disadvantages may be overcome by splicing a subdural electrode strip to the electrode leads so that skull growth is less likely to interfere with long-term signal capture and by placing two implants for a more extensive montage. This commercially available system in this bilateral cortical impact swine model may be useful to a wide range of investigators studying epileptogenesis in PTE.

show abstract

Noninvasive EEG Recordings from Freely Moving Piglets

Cited by 2 publications

References 13 publications

Robust, Long-Term Video EEG Monitoring in a Porcine Model of Post-Traumatic Epilepsy

Robust, Long-Term Video EEG Monitoring in a Porcine Model of Post-Traumatic Epilepsy

Robust, long-term video EEG monitoring in a porcine model of post-traumatic epilepsy

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