Noninvasive Evaluation of Benign and Malignant Superficial Lymph Nodes by Virtual Touch Tissue Quantification

Chen, Shaoqi; Lin, Xiaoming; Chen, Xiaoxia; Zheng, Bang

doi:10.7863/ultra.15.05053

Cited by 13 publications

(22 citation statements)

References 10 publications

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“…The results from our study show that the Young's modulus (i.e., measure of elasticity) from the lymph node cortex is significantly different when compared between reactive and malignant ALNs, distinguishing the two mechanisms with an accuracy of up to 92.3%. Our results concur with those of previous investigations on lymph nodes performed with other SWE techniques, such as Supersonic Imagine [13,14,16,26] and Virtual Touch Tissue Quantification [15,27] in that malignant lymph nodes presented higher elasticity than benign lymph nodes. Most of these studies focused on the preoperative value of US SWE and primarily evaluated axillary SLNs as a result.…”

Section: Discussionsupporting

confidence: 92%

“…[5,6]. These features can provide valuable information for the characterization of abnormal ALNs [7][8][9], and help identify lymph nodes suitable for needle biopsy [10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…In this study, B-mode US features and elasticity parameters were assessed to evaluate the predictive performance of CUSE for the differentiation of reactive and metastatic axillary lymph nodes. Although, other SWE techniques such as Supersonic Imagine [13,14,16,26] and Virtual tissue quantification [15,27] have been used to predict ALN metastasis; to the best of our knowledge, this is the first report showing the performance of CUSE for the differentiation of reactive and metastatic ALNs.…”

Section: Introductionmentioning

confidence: 99%

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Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation

et al. 2020

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Objectives To evaluate the predictive performance of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes. Methods From June 2014 through September 2018, 114 female volunteers (mean age 58.1±13.3 years; range 28-88 years) with enlarged axillary lymph nodes identified by palpation or clinical imaging were prospectively enrolled in the study. Mean, standard deviation and maximum shear wave elastography parameters from 117 lymph nodes were obtained and compared to fine needle aspiration biopsy results. Mann-Whitney U test and ROC curve analysis were performed. Results The axillary lymph nodes were classified as reactive or metastatic based on the fine needle aspiration outcomes. A statistically significant difference between reactive and metastatic axillary lymph nodes was observed based on comb-push ultrasound shear elastography (CUSE) results (p<0.0001) from mean and maximum elasticity values. Mean elasticity showed the best separation with a ROC analysis resulting in 90.5% sensitivity, 94.4% specificity, 0.97 area under the curve, 95% positive predictive value, and 89.5% negative predictive value with a 30.2-kPa threshold.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation

et al. 2020

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“…A total of 929 patients with 1084 LNs (469 malignant, 615 benign) were investigated. Patients’ age ranged from 1–85 years, while we failed to acquire this information from two articles [25, 27]. Three studies [25, 30, 31] did not concern about the gender distribution, and 47.7% were males for the remanent studies.…”

Section: Resultsmentioning

confidence: 99%

Acoustic Radiation Force Impulse Imaging for the Differentiation of Benign and Malignant Lymph Nodes: A Systematic Review and Meta-Analysis

Zhang

Zheng

et al. 2016

PLoS ONE

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ObjectiveTo evaluate the overall performance of acoustic radiation force impulse imaging (ARFI) in differentiating between benign and malignant lymph nodes (LNs) by conducting a meta-analysis.MethodsPubMed, Embase, Web of Science, the Cochrane Library and the China National Knowledge Infrastructure were comprehensively searched for potential studies through August 13th, 2016. Studies that investigated the diagnostic power of ARFI for the differential diagnosis of benign and malignant LNs by using virtual touch tissue quantification (VTQ) or virtual touch tissue imaging quantification (VTIQ) were collected. The included articles were published in English or Chinese. Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used to evaluate the methodological quality. The pooled sensitivity, specificity, and the area under the summary receiver operating characteristic (SROC) curve (AUC) were calculated by means of a bivariate mixed-effects regression model. Meta-regression analysis was performed to identify the potential sources of between study heterogeneity. Fagan plot analysis was used to explore the clinical utilities. Publication bias was assessed using Deek’s funnel plot.ResultsNine studies involving 1084 LNs from 929 patients were identified to analyze in the meta-analysis. The summary sensitivity and specificity of ARFI in detecting malignant LNs were 0.87 (95% confidence interval [CI], 0.83–0.91) and 0.88 (95% CI, 0.82–0.92), respectively. The AUC was 0.93 (95% CI, 0.90–0.95). The pooled DOR was 49.59 (95% CI, 26.11–94.15). Deek’s funnel plot revealed no significant publication bias.ConclusionARFI is a promising tool for the differentiation of benign and malignant LNs with high sensitivity and specificity.

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“…Также S. Q. Chen и соавт. определили сред нюю скорость сдвиговой волны для реактивной ги пер плазии ЛУ, которая составила 2,513 ± 0,357 м / с [17]. В своей работе S. Y. Chae и соавт.…”

Section: Introductionunclassified

Evaluation of the possibilities of shear wave elastography for differentiation of lymphomatous and reactive changes of superficial lymph nodes

et al. 2020

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Objective: to evaluate the possibilities of ultrasound elastography for differentiation of reactive and lymphomatous superficial lymph nodes (LN).Materials and methods. The prospective study included 138 patients with enlarged superficial LN. Based on a previous histological examination, patients were divided into two groups: 1st group (n = 108) – patients with non-Hodgkin’s lymphomas and Hodgkin’s lymphoma; 2nd (n = 30) – patients with reactive (inflammatory) changes in superficial LN. All patients underwent ultrasound elastography of the enlarged LN using ARFI technology.Results. According to the results of ultrasound elastography, the average, minimum, and maximum shear wave velocities for enlarged LN in lymphoma (1st group) were 2.616 ± 0.684; 1.980 ± 0.557 and 3.351 ± 0.987 m / s, respectively; for LN with reactive changes (2nd group) – 1.704 ± 0.223; 1.414 ± 0.209 and 2.027 ± 0.261 m / s, respectively. Thus, the average, minimum, and maximum values of shear wave velocities significantly different between the groups (p ˂0.001). The cut off values of the average shear wave velocity in the differential diagnosis of lymphoma and hyperplasia are determined at the level of 2.05 m / s, with a sensitivity of 88.5 %, specificity of 100 %, and AUC of 0.942 (p ˂0.001).Conclusion. Ultrasound elastography demonstrated statistically significant differences in shear wave velocity in the enlarged superficial LN in lymphoma and in inflammatory processes that can be used as a preliminary non-invasive differential diagnosis of enlarged superficial LN in these conditions.

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Noninvasive Evaluation of Benign and Malignant Superficial Lymph Nodes by Virtual Touch Tissue Quantification

Abstract: Virtual Touch tissue quantification provides a promising noninvasive strategy for differentiation of benign and malignant superficial lymph node lesions.

Cited by 13 publications

References 10 publications

Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation

Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation

Acoustic Radiation Force Impulse Imaging for the Differentiation of Benign and Malignant Lymph Nodes: A Systematic Review and Meta-Analysis

Evaluation of the possibilities of shear wave elastography for differentiation of lymphomatous and reactive changes of superficial lymph nodes

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