SummaryBackground: A major goal of revascularization is the recovery of left ventricular (LV) function. Nuclear imaging techniques are widely used for detecting recovery of function with a good sensitivity, but only moderate specificity. Predictors of recovery in chronic total coronary occlusions (CTO) are not investigated.Hypothesis: The 12-lead-resting electrocardiogram (ECG) is a predictor of LV recovery after successful recanalization of CTO.Methods: Successful recanalization of CTO was performed in 127 patients. Of these, 62 patients, who constitute the study group, had impaired regional wall motion prior to recanalization. The 12-lead resting ECG was evaluated for Q-wave areas and parameters of QT dispersion. Impairment of regional wall motion was evaluated by LV angiogram at baseline and at follow-up.Results: Angiographic follow-up after 5 ± 1.4 months documented reocclusion in eight patients. Complete follow-up with a patent coronary artery and an ECG without bundlebranch block was available in 43 patients. Wall motion severity index (WMSI) improved from Ϫ2.92 ± 0.28 to Ϫ1.34 ± 0.61 (p < 0.001) in patients without Q waves, whereas it was unchanged in patients with Q waves (Ϫ3.01 ± 0.30 and Ϫ2.81 ± 0.32). Absence of Q waves at baseline predicted recovery of regional wall motion with 89% sensitivity and 67% specifici-