Noninvasive Evaluation of Kidney Hypoxia and Fibrosis Using Magnetic Resonance Imaging

Inoue, Tsutomu; Kozawa, Eito; Okada, Hirokazu; Inukai, Kouichi; Watanabe, Shinichi; Kikuta, Tomohiro; Watanabe, Yusuke; Takenaka, Tsuneo; Katayama, Shigehiro; Tanaka, Junji; Suzuki, Hiromichi

doi:10.1681/asn.2010111143

Cited by 316 publications

(294 citation statements)

References 23 publications

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“…The increased medullary oxygen content in patients may suggest that the reduction of renal oxygen consumption (as a result of the known reduced tubular fractional reabsorption of sodium) may influence the change in oxygen concentration. 19,20 Consistent with the findings of others, 21 medullary R2* values were negatively associated with eGFR in patients with PNS in the present study, indicating that BOLD MRI reflects renal function. The absence of correlation between R2* values and serum creatinine in the present study may be explained by the fact that this parameter is affected by extrarenal factors including age, weight, diet and drug use.…”

Section: Discussionsupporting

confidence: 93%

Noninvasive evaluation of renal oxygenation in primary nephrotic syndrome with blood oxygen level dependent magnetic resonance imaging: Initial experience

et al. 2015

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Objectives: To use blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) to evaluate renal oxygenation in patients with primary nephrotic syndrome (PNS), and test the hypothesis that renal tissue oxygenation correlates with renal function, tubulointerstitial alterations and treatment response. Methods: Patients with untreated first-onset PNS and healthy control subjects underwent BOLD MRI. Blood and urine samples were obtained on the day of MRI, and patients underwent renal biopsy the day after MRI. Renal tubulointerstitial damage scores (TIDS) were determined using Katafuchi criteria. All patients received corticosteroids within 7 days after MRI and were followed up for 12 months. Results: Medullary R2* values were significantly lower in patients with PNS (n ¼ 20) than controls (n ¼ 18). Medullary R2* values were negatively correlated with estimated glomerular filtration rates and positively correlated with TIDS in patients with PNS. There were no significant differences in medullary or cortical R2* values when patients were classified according to treatment response.

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Section: Discussionsupporting

confidence: 93%

Noninvasive evaluation of renal oxygenation in primary nephrotic syndrome with blood oxygen level dependent magnetic resonance imaging: Initial experience

et al. 2015

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“…For example, renal hypoxia has been measured in patients after AKI and patients with progressive CKD using blood oxygen level-dependent magnetic resonance imaging (MRI). 60 Fibrosisspecific contrast agents designed to target collagen in MRI studies and 64 Cu-labeled collagen-specific peptides used in PET imaging have been reported to detect rodent liver or cardiac fibrosis models. 61,62 Elastography techniques have been developed using MRI or ultrasound imaging that measure tissue sample stiffness; these techniques have been applied in preclinical models of kidney fibrosis.…”

Section: Question 4 Can Progression To Ckd Be Predicted After Aki Anmentioning

confidence: 99%

Progression after AKI

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Mehta

et al. 2016

Journal of the American Society of Nephrology

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Recent clinical studies indicate a strong link between AKI and progression of CKD. The increasing prevalence of AKI must compel the nephrology community to consider the long-term ramifications of this syndrome. Considerable gaps in knowledge exist regarding the connection between AKI and CKD. The 13th Acute Dialysis Quality Initiative meeting entitled "Therapeutic Targets of Human Acute Kidney Injury: Harmonizing Human and Experimental Animal Acute Kidney Injury" convened in April of 2014 and assigned a working group to focus on issues related to progression after AKI. This article provides a summary of the key conclusions and recommendations of the group, including an emphasis on terminology related to injury and repair processes for both clinical and preclinical studies, elucidation of pathophysiologic alterations of AKI, identification of potential treatment strategies, identification of patients predisposed to progression, and potential management strategies.

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“…From personal experience, we know that kidney stiffness is much less altered compared to the liver during fibrosis, suggesting that elastography in kidneys might not be sensitive enough for assessment of fibrosis. A third approach suggested to measure renal fibrosis is diffusion-weighted MRI (427)(428)(429)(430)(431)(432)(433)(434)(435)(436)(437). Presently it is unclear whether any of these modalities specifically reflects renal fibrosis.…”

Section: Imagingmentioning

confidence: 99%

Renal Allograft Fibrosis: Biology and Therapeutic Targets

Floege

2015

American Journal of Transplantation

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Noninvasive Evaluation of Kidney Hypoxia and Fibrosis Using Magnetic Resonance Imaging

Cited by 316 publications

References 23 publications

Noninvasive evaluation of renal oxygenation in primary nephrotic syndrome with blood oxygen level dependent magnetic resonance imaging: Initial experience

Noninvasive evaluation of renal oxygenation in primary nephrotic syndrome with blood oxygen level dependent magnetic resonance imaging: Initial experience

Progression after AKI

Renal Allograft Fibrosis: Biology and Therapeutic Targets

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